Results 81 to 90 of about 26,165 (305)

Immunomodulators, associated or not with systemic antibiotics, to treat periodontitis: A 1‐year multicenter, placebo‐controlled, double‐blind, randomized clinical trial

open access: yesJournal of Periodontology, EarlyView.
Abstract Background Immunomodulatory agents such as omega‐3 (ω‐3) and low‐dose aspirin (ASA) have been proposed as effective adjuncts in the treatment of periodontitis. However, they still lack long‐term studies and head‐to‐head evaluation with metronidazole (MTZ) and amoxicillin (AMX), the adjunct protocol with the strongest scientific evidence of ...
Nidia C. Castro dos Santos   +14 more
wiley   +1 more source

Functional Analysis and Tissue-Specific Expression of Calcitonin and CGRP with RAMP-Modulated Receptors CTR and CLR in Chickens

open access: yesAnimals
Calcitonin (CT) and calcitonin gene-related peptide (CGRP) are critical regulators of calcium balance and have extensive implications for vertebrate physiological processes.
Tianjiao Huang   +8 more
doaj   +1 more source

Evolution of secretin family GPCR members in the metazoa

open access: yesBMC Evolutionary Biology, 2006
Background Comparative approaches using protostome and deuterostome data have greatly contributed to understanding gene function and organismal complexity.
Clark Melody S   +4 more
doaj   +1 more source

Can trigeminal sensations impact saltiness perception? A mini‐review

open access: yesJournal of the Science of Food and Agriculture, EarlyView.
Abstract Many food companies have begun to reduce the salt content in their products due to health concerns; however, this reduction in salt content can affect the food's sensory appeal and flavour complexity. Flavour is defined as a combination of odour (i.e., smell), taste (i.e., gustation) and trigeminal sensations (i.e., chemesthesis).
Emily Dolan   +2 more
wiley   +1 more source

Safety and Efficacy of 10 kHz Spinal Cord Stimulation for the Treatment of Refractory Chronic Migraine: A Prospective Long‐Term Open‐Label Study

open access: yesNeuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Background Refractory chronic migraine (rCM) is a highly disabling condition for which novel safe and effective treatments are needed. Safety and long‐term efficacy of paresthesia‐free high cervical 10 kHz spinal cord stimulation (SCS) were here prospectively evaluated for the treatment of rCM.
Adnan Al‐Kaisy   +7 more
wiley   +1 more source

Structural Determinants in the Calcitonin Receptor-Like Receptor (Crlr) Important for Cgrp and Adrenomedullin (Am) Receptor Function of Crlr/Receptor-Activity-Modifying Protein (Ramp) 1 and Crlr/Ramp2 Heterodimers

open access: yesThe Scientific World Journal, 2001
Cell surface protein cross-linking, coimmmunoprecipitation, and confocal microscopy identified CRLR/RAMP1-, CRLR/RAMP2-, and calcitonin receptor isotype 2 (CTR2)/RAMP1 heterodimers as CGRP-, AM-, and CGRP/amylin receptors, linked to cAMP production ...
W. Born   +4 more
doaj   +1 more source

Pregabalin Efficacy in Treatment of Chronic Neurogenic Cough

open access: yesThe Laryngoscope, EarlyView.
The use of neuromodulators for chronic cough has increased; however, the choice of medication, dosing regimen, and duration are still unclear. This longitudinal study of 95 adults taking pregabalin, 75 mg twice daily, for CNC demonstrated 78% improvement or resolution of cough, 17% unchanged, 1% worse cough, with a mean of 6 weeks of therapy, and only ...
Jacqui Allen   +3 more
wiley   +1 more source

Antagonism of CGRP Signaling by Rimegepant at Two Receptors

open access: yesFrontiers in Pharmacology, 2020
The “gepants” are a class of calcitonin gene-related peptide (CGRP) receptor antagonist molecules that have been developed for the prevention and treatment of migraine.
Kylie S. Pan   +8 more
doaj   +1 more source

Calcitonin receptor antibodies in the identification of osteoclasts

open access: yesBone, 1999
Osteoclasts are the cells responsible for bone resorption, and their number and rate of formation are critical in determining bone mass. To identify and quantify osteoclasts, as well as to study their formation in bone and in osteoclastogenic cultures, osteoclast-specific cell markers are required.
Quinn, J. M.W.   +8 more
openaire   +3 more sources

Multinucleated rat alveolar macrophages express functional receptors for calcitonin

open access: yes, 1991
The fusion of mononuclear phagocytes occurs spontaneously in vivo and leads to the differentiation of either multinucleated giant cells or osteoclasts in chronic inflammatory sites or in bone, respectively.
A. Vignery   +4 more
core   +1 more source

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