Results 11 to 20 of about 39,277 (265)
Scientific Reports, 2022 This study analyzed severe acute endometritis action on myometrial density and distribution of protein gene product (PGP)9.5- and calcitonin gene-related peptide (CGRP)-like immunoreactive nerve fibers and calcitonin receptor-like receptor (CLR ...
Barbara Jana +3 more
doaj +1 more source
Bioinformatics analysis identifies key genes of prognostic value in lung cancer [PDF]
Journal of Men's Health, 2023 Lung cancer is the most common human malignancy worldwide and can be divided into different types of carcinomas depending on their pathological features.
Dan Song, Li Sun
doaj +1 more source
A Native PAGE Assay for the Biochemical Characterization of G Protein Coupling to GPCRs
Bio-Protocol, 2021 G protein-coupled receptors (GPCRs) are a large family of membrane-embedded receptors that have diverse roles in physiology and are major drug targets. GPCRs transduce an agonist binding signal across the membrane to activate intracellular heterotrimeric
Amanda Roehrkasse +2 more
doaj +1 more source
Selective CGRP and adrenomedullin peptide binding by tethered RAMP‐calcitonin receptor‐like receptor extracellular domain fusion proteins [PDF]
Protein Science, 2013 AbstractCalcitonin gene‐related peptide (CGRP) and adrenomedullin (AM) are related peptides that are potent vasodilators. The CGRP and AM receptors are heteromeric protein complexes comprised of a shared calcitonin receptor‐like receptor (CLR) subunit and a variable receptor activity modifying protein (RAMP) subunit.
Heather E, Moad, Augen A, Pioszak
openaire +2 more sources
The Journal of Headache and Pain, 2022 Background The clinical use of calcitonin gene-related peptide receptor (CGRP-R) antagonists and monoclonal antibodies against CGRP and CGRP-R has offered new treatment possibilities for migraine patients.
Sanne Hage La Cour +6 more
doaj +1 more source
The Extracellular Domain of Receptor Activity-modifying Protein 1 Is Sufficient for Calcitonin Receptor-like Receptor Function [PDF]
Journal of Biological Chemistry, 2003 A functional calcitonin gene-related peptide (CGRP) receptor requires dimerization of calcitonin receptor-like receptor (CRLR) with receptor activity-modifying protein 1 (RAMP 1). To determine the function of the three domains (extracellular, ECD; transmembrane, TM; and tail domains) of human RAMP 1, three mutants were constructed: RAMP 1 without the ...
Timothy J, Fitzsimmons +2 more
openaire +2 more sources
Immunohistochemical Localization of Calcitonin Receptor–Like Receptor and Receptor Activity–Modifying Proteins in the Human Cerebral Vasculature [PDF]
Journal of Cerebral Blood Flow & Metabolism, 2002 Calcitonin gene-related peptide and adrenomedullin belong to a structurally related neuropeptide family and are potent vasodilators expressed in the trigeminovascular system. The molecular identity of receptors for these proteins has only recently been elucidated.
Kevin R, Oliver +4 more
openaire +2 more sources
Calcitonin Related Polypeptide Alpha Mediates Oral Cancer Pain
Cells, 2023 Oral cancer patients suffer pain at the site of the cancer. Calcitonin gene related polypeptide (CGRP), a neuropeptide expressed by a subset of primary afferent neurons, promotes oral cancer growth.
Nguyen Huu Tu +14 more
doaj +1 more source
Food Science and Human Wellness, 2019 Calcitonin receptor-like receptor (CRLR) is a human protein, that produces a calcitonin gene-related peptide receptor (CGRP) when associates with human receptor activity-modifying protein-1 (HRAMP1).
Parthasarathy V., Ajay Kumar T.V
doaj +1 more source
The role of ECL2 in CGRP receptor activation: a combined modelling and experimental approach [PDF]
, 2013 The calcitonin gene-related peptide (CGRP) receptor is a complex of a calcitonin receptor-like receptor (CLR), which is a family B G-protein-coupled receptor (GPCR) and receptor activity modifying protein 1.
Alex C. Conner +13 more
core +2 more sources