, 2008 This report contains a gene expression summary of the oculomotor nucleus, derived from the Allen Brain Atlas (ABA) in situ hybridization mouse data set.
Allen Institute for Brain Science +3 more
core +2 more sources
Possible sites of action of the new calcitonin gene-related peptide receptor antagonists
Therapeutic Advances in Neurological Disorders, 2010 Migraine is considered a neurovascular disease affecting more than 10% of the general population. Currently available drugs for the acute treatment of migraine are vasoconstrictors, which have limitations in their therapeutic use.
Sajedeh Eftekhari, Lars Edvinsson
doaj +1 more source
Determining the Effects of Differential Expression of GRKs and β-arrestins on CLR-RAMP Agonist Bias
Frontiers in Physiology, 2022 Signalling of the calcitonin-like receptor (CLR) is multifaceted, due to its interaction with receptor activity modifying proteins (RAMPs), and three endogenous peptide agonists.
Abigail Pearce +5 more
doaj +1 more source
Loss of receptor activity-modifying protein 2 in mice causes placental dysfunction and alters PTH1R regulation. [PDF]
PLoS ONE, 2017 Receptor activity-modifying protein 2 (Ramp2) is a single-pass transmembrane protein that heterodimerizes with several family B G-protein coupled receptors to alter their function.
Mahita Kadmiel +4 more
doaj +1 more source
RAMP1 as a novel prognostic biomarker in pan-cancer and osteosarcoma.
PLoS ONE, 2023 Receptor activity modifying protein 1 (RAMP1) facilitates the localization of the calcitonin-like receptor (CLR) to the plasma membrane, but its role in osteosarcoma (OS) remains unclear.
Long Xie +3 more
doaj +1 more source
Coexpression of Calcitonin Receptor-Like Receptor and Receptor Activity-Modifying Protein 2 or 3 Mediates the Antimigratory Effect of Adrenomedullin [PDF]
Endocrinology, 2003 Three isoforms of the receptor activity-modifying protein (RAMP) are thought to transport the calcitonin receptor-like receptor (CRLR) to the plasma membrane to function as calcitonin gene-related peptide or adrenomedullin receptors, but their role remains largely unknown.
Nozomi, Fukai +4 more
openaire +2 more sources
, 2013 Purpose of review: This review discusses the current developments in biomarkers for sepsis. Recent findings: With quantum leaps in technology, an array of biomarkers will become available within the next decade as point-of-care tools that will likely ...
Singer, M
core +1 more source
Autocrine Signaling in Cardiac Remodeling: A Rich Source of Therapeutic Targets
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021 The myocardium consists of different cell types, of which endothelial cells, cardiomyocytes, and fibroblasts are the most abundant. Communication between these different cell types, also called paracrine signaling, is essential for normal cardiac ...
Vincent F. M. Segers +1 more
doaj +1 more source
Expression of calcitonin gene-related peptide receptor components, calcitonin receptor-like receptor and receptor activity modifying protein 1, in the rat placenta during pregnancy and their cellular localization [PDF]
Molecular Human Reproduction, 2003 Calcitonin gene-related peptide (CGRP), one of the most potent endogenous vasodilators known, has been implicated in vascular adaptations and placental function during pregnancy. The present study was aimed to investigate mRNA expression of CGRP-A receptor components, calcitonin receptor-like receptor (CRLR) and receptor activity modifying protein 1 ...
Y L, Dong +3 more
openaire +2 more sources
Frequent mild head injury promotes trigeminal sensitivity concomitant with microglial proliferation, astrocytosis, and increased neuropeptide levels in the trigeminal pain system. [PDF]
, 2017 BACKGROUND: Frequent mild head injuries or concussion along with the presence of headache may contribute to the persistence of concussion symptoms. METHODS: In this study, the acute effects of recovery between mild head injuries and the frequency of ...
Assari, Soroush +4 more
core +2 more sources