Results 61 to 70 of about 39,277 (265)

The neuropeptide calcitonin gene-related peptide alpha is essential for bone healing

EBioMedicine, 2020
Background: Impaired fracture healing represents an ongoing clinical challenge, as treatment options remain limited. Calcitonin gene-related peptide (CGRP), a neuropeptide targeted by emerging anti-migraine drugs, is also expressed in sensory nerve ...
Jessika Appelt, Anke Baranowsky, Denise Jahn, Timur Yorgan, Paul Köhli, Ellen Otto, Saeed Khomeijani Farahani, Frank Graef, Melanie Fuchs, Aarón Herrera, Michael Amling, Thorsten Schinke, Karl-Heinz Frosch, Georg N. Duda, Serafeim Tsitsilonis, Johannes Keller   +15 more
doaj   +1 more source

Functional Calcitonin Gene-related Peptide Receptors Are Formed by the Asymmetric Assembly of a Calcitonin Receptor-like Receptor Homo-oligomer and a Monomer of Receptor Activity-modifying Protein-1 [PDF]

Journal of Biological Chemistry, 2007
In addition to their interactions with hetero-trimeric G proteins, seven-transmembrane domain receptors are now known to form multimeric complexes that can include receptor homo- or hetero-oligomers and/or accessory proteins that modulate their activity.
Madeleine, Héroux, Mireille, Hogue, Sébastien, Lemieux, Michel, Bouvier   +3 more
openaire   +2 more sources

Histamine and Histamine H4 Receptor Promotes Osteoclastogenesis in Rheumatoid Arthritis. [PDF]

, 2017
Histamine H4 receptor (H4R) has immune-modulatory and chemotaxic effects in various immune cells. This study aimed to determine the osteoclastogenic role of H4R in rheumatoid arthritis (RA).
Firestein, Gary S, Kim, Bo-Mi, Kim, Hae-Rim, Kim, Kyoung-Woon, Lee, Kyung-Ann, Lee, Sang-Heon   +5 more
core   +1 more source

Photoaffinity Cross-Linking and Unnatural Amino Acid Mutagenesis Reveal Insights into Calcitonin Gene-Related Peptide Binding to the Calcitonin Receptor-like Receptor/Receptor Activity-Modifying Protein 1 (CLR/RAMP1) Complex [PDF]

Biochemistry, 2018
Calcitonin gene-related peptide (CGRP) binds to the complex of the calcitonin receptor-like receptor (CLR) with receptor activity-modifying protein 1 (RAMP1). How CGRP interacts with the transmembrane domain (including the extracellular loops) of this family B receptor remains unclear.
John Simms, Romez Uddin, Thomas P. Sakmar, Joseph J. Gingell, Michael L. Garelja, Debbie L. Hay, Margaret A. Brimble, Paul W. Harris, Christopher A. Reynolds, David R. Poyner   +9 more
openaire   +4 more sources

Motor Nucleus of the Trigeminal Nerve [PDF]

, 2008
This report contains a summary of expression patterns for genes that are enriched in the motor nucleus of the trigeminal nerve (V) of the pons. All data is derived from the Allen Brain Atlas (ABA) in situ hybridization mouse project. The structure's
Allen Institute for Brain Science, Angela L. Guillozet-Bongaarts, Lydia L. Ng, Nicholas A. Kostakis   +3 more
core   +2 more sources

Calcitonin receptor‐like receptor (CLR), receptor activity‐modifying protein 1 (RAMP1), and calcitonin gene‐related peptide (CGRP) immunoreactivity in the rat trigeminovascular system: Differences between peripheral and central CGRP receptor distribution [PDF]

Journal of Comparative Neurology, 2008
AbstractCGRP meets its receptor in the rat dura mater. The CGRP receptor protein CLR (green) is expressed in smooth muscle cells (blue, SMA) in the media of meningeal arteries (left) but not in veins (right upper half). CLR is also found in trigeminal nerve bundles and mononuclear cells adjacent to the arteries. CGRP‐receptor components are however not
Lennerz, J., Rühle, V., Ceppa, E., Neuhuber, W., Bunnett, N., Grady, E., Messlinger, K.   +6 more
openaire   +3 more sources

The role of epidermal growth factor-like module containing mucin-like hormone receptor 2 in human cancers. [PDF]

, 2014
G-protein coupled receptors (GPCRs) are among the most diverse and ubiquitous proteins in all of biology. The epidermal growth factor-seven span transmembrane (EGF-TM7) subfamily of adhesion GPCRs is a small subset whose members are mainly expressed on ...
Bloch, Orin, Ivan, Michael E, Kaur, Gurvinder, Oh, Michael C, Oh, Taemin, Parsa, Andrew T, Safaee, Michael, Sayegh, Eli T, Sun, Matthew Z   +8 more
core   +2 more sources

Whole-exome sequencing of calcitonin-producing pancreatic neuroendocrine neoplasms indicates a unique molecular signature

Frontiers in Oncology, 2023
IntroductionCalcitonin-producing pancreatic neuroendocrine neoplasms (CT-pNENs) are an extremely rare clinical entity, with approximately 60 cases reported worldwide.
Claudia Döring, Katharina Peer, Katrin Bankov, Carmen Bollmann, Annette Ramaswamy, Pietro Di Fazio, Peter Johannes Wild, Peter Johannes Wild, Detlef Klaus Bartsch   +8 more
doaj   +1 more source

Protein-Protein Interaction and Not Glycosylation Determines the Binding Selectivity of Heterodimers between the Calcitonin Receptor-like Receptor and the Receptor Activity-modifying Proteins [PDF]

Journal of Biological Chemistry, 2001
The receptor activity-modifying proteins (RAMPs) and the calcitonin receptor-like receptor (CRLR) are both required to generate adrenomedullin (AM) and calcitonin gene-related peptide (CGRP) receptors. A mature, fully glycosylated, form of CRLR was associated with (125)I-CGRP binding, upon co-expression of RAMP1 and CRLR.
S, Hilairet, S M, Foord, F H, Marshall, M, Bouvier   +3 more
openaire   +2 more sources

Area Postrema [PDF]

, 2008
This report contains a gene expression summary of the area postrema (AP), derived from the "Allen Brain Atlas":http://www.brain-map.org/welcome.do;jsessionid=EDE40ADC940845D169DE378ADC9B71BD (ABA) in-situ hybridization (ISH) mouse data set ...
Allen Institute for Brain Science, John A. Morris, Katie J. Glattfelder, Lydia L. Ng   +3 more
core   +2 more sources