Results 101 to 110 of about 42,581 (243)

Effect of exogenous calcitriol on myopia development and axial length in guinea pigs with form deprivation myopia

open access: yesScientific Reports
The annual increase in myopia prevalence poses a significant economic and health challenge. Our study investigated the effect of calcitriol role in myopia by inducing the condition in guinea pigs through form deprivation for four weeks.
Rongbin Liang   +6 more
doaj   +1 more source

Association Discovery Approach in Healthcare Big Data to Identify Drug Safety and Drug Repurposing Signals

open access: yesClinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 228-240, January 2026.
Data science approaches have been increasingly implemented in healthcare big data to evaluate the safety and effectiveness of drugs. Association discovery is a data mining approach that finds potentially associated elements in high‐dimensional data. We present a novel implementation of the association discovery approach in longitudinal healthcare data ...
George S. Q. Tan   +6 more
wiley   +1 more source

Impact of Preoperative Calcium and Magnesium Supplementation on Quality of Life and Hypocalcemia Post‐Thyroidectomy

open access: yesEndocrinology, Diabetes &Metabolism, Volume 9, Issue 1, January 2026.
Postoperative QoL improved in both groups, with earlier gains in Graves' disease patients receiving supplementation. Hypocalcemia and hypoparathyroidism rates were lower in the intervention group, which also showed higher calcium levels and fewer symptoms. Vitamin D deficiency was common but unrelated to hypocalcemia.
Navid Tabriz   +3 more
wiley   +1 more source

Risk of Permanent Hypoparathyroidism Requiring Calcitriol Therapy in a Population-Based Cohort of Adults Older Than 65 Undergoing Total Thyroidectomy for Graves' Disease [PDF]

open access: green, 2022
Carolyn D. Seib   +8 more
openalex   +1 more source

Natural Products Targeting Notch Signaling in Cancer: Mechanistic Insights and Food‐Based Chemoprevention Potential

open access: yesFood Frontiers, Volume 7, Issue 1, January 2026.
The Notch signaling pathway plays a dual role in cancer, acting as both a tumor promoter and suppressor depending on cellular context. This review highlights how natural products modulate Notch signaling to inhibit tumor initiation, progression, angiogenesis, and cancer stem cell maintenance.
Rabab Fatima   +15 more
wiley   +1 more source

Blocking Sphingosine 1‐phosphate Metabolism With Fingolimod Prevents the Progression of Vascular Smooth Muscle Cells Calcification in Chronic Kidney Disease

open access: yesJournal of Cellular Physiology, Volume 241, Issue 1, January 2026.
ABSTRACT Patients with chronic kidney disease, and particularly those under hemodialysis, are prone to develop cardiovascular complications, mostly due to the exacerbation of vascular calcification. Vascular calcification relies on the transdifferentiation of vascular smooth muscle cells into calcifying cells.
Najwa Skafi   +16 more
wiley   +1 more source

Serum Visfatin Level and Cardiac Valve Calcifcation in Hemodialysis Patients

open access: yesHemodialysis International, Volume 30, Issue 1, Page 101-109, January 2026.
ABSTRACT Background Cardiac valve calcification is a serious complication in patients with cardiovascular disease. This study investigated the relationship between visfatin levels and cardiac valve calcification in individuals undergoing hemodialysis.
Xiaoqi Wang   +5 more
wiley   +1 more source

Calcitriol Attenuates Doxorubicin-Induced Cardiac Dysfunction and Inhibits Endothelial-to-Mesenchymal Transition in Mice

open access: yesCells, 2019
Doxorubicin (Dox) is an effective anti-neoplasm drug, but its cardiac toxicity limits its clinical use. Endothelial-to-mesenchymal transition (EndMT) has been found to be involved in the process of heart failure.
Tzu-Hsien Tsai   +3 more
doaj   +1 more source

Intersections of vitamin D deficiency, HIV and chronic liver diseases

open access: yesHIV Medicine, Volume 27, Issue 1, Page 4-17, January 2026.
Abstract Objectives Despite effective antiretroviral therapy (ART), chronic liver diseases remain a leading cause of morbidity and mortality among people with HIV, with metabolic dysfunction–associated steatotic liver disease (MASLD) now the predominant etiology. Vitamin D deficiency is also highly prevalent in this population.
Francesca Farina   +7 more
wiley   +1 more source

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