Results 11 to 20 of about 49,400 (296)

A genetic validation study reveals a role of vitamin D metabolism in the response to interferon-alfa-based therapy of chronic hepatitis C [PDF]

PLoS ONE, 2012
Background: To perform a comprehensive study on the relationship between vitamin D metabolism and the response to interferon-α-based therapy of chronic hepatitis C.
Badenhoop, Klaus, Berg, Thomas, Bibert, Stephanie, Bochud, Pierre-Yves, Bojunga, Jörg, Burgisser, Philippe, Cerny, Andreas, Dufour, Jean-François, Geier, Andreas, Gerlach, Tilman J, Heim, Markus H, Kutalik, Zoltan, Lange, Christian M, Malinverni, Raffaele, Moradpour, Darius, Müller, Tobias, Negro, Francesco, Regenass, Stephan, Sarrazin, Christoph, Swiss Hepatitis C Cohort Study Group,, Zeuzem, Stefan   +20 more
core   +29 more sources

Immunomodulatory mechanisms of action of calcitriol in psoriasis

Indian Journal of Dermatology, 2014
Background: Calcitriol is well known for its therapeutic efficacy in psoriasis, but its mechanism of action is still unclear. In this study, we tried to elucidate the precise mechanism of calcitriol for its therapeutic efficacy in psoriasis.
Suravi Raychaudhuri, Anupam Mitra, Ananya Datta-Mitra   +2 more
doaj   +4 more sources

Transcriptomic profile induced by calcitriol in CaSki human cervical cancer cell line. [PDF]

PLoS ONE
The vitamin D endocrine system, primarily mediated by its main metabolite calcitriol and the vitamin D receptor (VDR), plays a critical role in numerous human physiological processes, ranging from calcium metabolism to the prevention of various tumors ...
Euclides Avila, Luis David Hernández-Monterde, Alberto Cedro-Tanda, Tomas Misael Lizardi-Aguilera, David Barrera, Francisco Vladimir Villegas-Rodriguez, Janice García-Quiroz, Lorenza Díaz, Fernando Larrea   +8 more
doaj   +2 more sources

Harnessing tomato-derived small extracellular vesicles as drug delivery system for cancer therapy [PDF]

Future Science OA
Aim This study aims to explore a sustainable and scalable approach using tomato fruit-derived sEVs (TsEVs) to deliver calcitriol for enhanced anticancer effects, addressing challenges of low yield and high costs associated with mammalian cell-derived ...
Kartik Kumar Sarwareddy, Anula Divyash Singh, Sreekanth Patnam, Babiola Annes Sesuraj, spd Ponamgi, Basant Kumar Thakur, Venkata Sasidhar Manda   +6 more
doaj   +2 more sources

Head-to-head comparison of tazarotene and calcitriol with or without sequential therapy in mild-to-moderate psoriasis: A randomized open-label study

Journal of Research in Pharmacy Practice, 2023
Objective: Psoriasis is an autoimmune disease that causes rapid turnover of skin cells. It is a chronic disease that affects a patient's quality of life significantly and frequently requires long-term treatment.
Jaspreet Kaur Sidhu, Prithpal Singh Matreja, Ashwani Kumar Gupta, Amandeep Singh, Surjit Singh   +4 more
doaj   +1 more source

Effects of Ruxolitinib and Calcitriol Combination Treatment on Various Molecular Subtypes of Breast Cancer

International Journal of Molecular Sciences, 2022
The anticancer effects of ruxolitinib and calcitriol against breast cancer were reported previously. However, the effect of ruxolitinib and calcitriol combination treatment on various molecular subtypes of breast cancer remains unexplored. In this study,
Jean Schneider, Y. Jeon, Y. Suh, S. Lim
semanticscholar   +1 more source

Peroxygenase-Catalyzed Selective Synthesis of Calcitriol Starting from Alfacalcidol

Antioxidants, 2022
Calcitriol is an active analog of vitamin D3 and has excellent physiological activities in regulating healthy immune function. To synthesize the calcitriol compound, the concept of total synthesis is often adopted, which typically involves multiple steps
Yuanying Li, Pengpeng Zhang, Zhoutong Sun, Huanhuan Li, Ran Ge, X. Sheng, Wuyuan Zhang   +6 more
semanticscholar   +1 more source

Calcitriol Alleviates Hyperosmotic Stress-Induced Corneal Epithelial Cell Damage via Inhibiting the NLRP3–ASC–Caspase-1–GSDMD Pyroptosis Pathway in Dry Eye Disease

Journal of Inflammation Research, 2021
Purpose Inflammasome activation in response to elevated tear osmolarity behaves as an initial signal in dry eye-related corneal inflammation. Pyroptosis is another prominent consequence of inflammasome activation, which is featured by gasdermin D (GSDMD)-
Jing Zhang, Yiqin Dai, Yujing Yang, Jianjiang Xu   +3 more
semanticscholar   +1 more source

Impact of calcitriol and an AKT inhibitor, AT7867, on survival of rat C6 glioma cells

Biotechnology & Biotechnological Equipment, 2021
Glioma is the most prevalent and lethal type of primary tumor of central nervous system. The regulatory role of calcitriol, the active form of vitamin D3, has been determined in various cellular processes including cell survival and apoptosis.
Ozlem Kucukhuseyin, Aris Cakiris, Mehmet Tolgahan Hakan, Cem Horozoglu, Erdem Tuzun, Ilhan Yaylim   +5 more
doaj   +1 more source

Combinations of Calcitriol with Anticancer Treatments for Breast Cancer: An Update

International Journal of Molecular Sciences, 2021
Preclinical, clinical, and epidemiological studies indicate that vitamin D3 (VD) deficiency is a risk factor for the development of breast cancer. Underlying mechanisms include the ability of calcitriol to induce cell differentiation, inhibit oncogenes ...
Mariana Segovia-Mendoza, Janice García-Quiroz, L. Díaz, R. García-Becerra   +3 more
semanticscholar   +1 more source