Results 11 to 20 of about 21,185 (156)

Calcitriol confers neuroprotective effects in traumatic brain injury by activating Nrf2 signaling through an autophagy-mediated mechanism

Molecular Medicine, 2021
Background The present study aimed to further explore the potential interaction between oxidative stress and autophagy in the progression of traumatic brain injury (TBI) and therapeutic mechanism of calcitriol, the active form of vitamin D (VitD ...
Changmeng Cui, Changshui Wang, Feng Jin, Mengqi Yang, Lingsheng Kong, Wenxiu Han, Pei Jiang   +6 more
doaj   +1 more source

Calcitriol-enhanced autophagy in gingival epithelium attenuates periodontal inflammation in rats with type 2 diabetes mellitus

Frontiers in Endocrinology, 2023
Type 2 diabetes mellitus (T2DM)-associated periodontitis is a common disease with high prevalence, associated with persistent infection and complicated manifestations.
Yanan Wang, Maoting Huang, Wanlin Xu, Fulong Li, Chunliang Ma, Xiaolin Tang   +5 more
doaj   +1 more source

Induction of the Vitamin D Receptor Attenuates Autophagy Dysfunction-Mediated Cell Death Following Traumatic Brain Injury

Cellular Physiology and Biochemistry, 2017
Background/Aims: Traumatic brain injury (TBI) is a major public health problem in the world and causes high rates of mortality and disability. Recent evidence suggests that vitamin D (VD) has neuroprotective actions and can promote function recovery ...
Changmeng Cui, Jianzhong Cui, Feng Jin, Ying Cui, Ran Li, Xiaohua Jiang, Yanxia Tian, Kaijie Wang, Pei Jiang, Junling Gao   +9 more
doaj   +1 more source

RETRACTED: Progesterone-Calcitriol Combination Enhanced Cytotoxicity of Cisplatin in Ovarian and Endometrial Cancer Cells In Vitro

Biomedicines, 2020
Initially, patients that respond to cisplatin (DDP) treatment later relapse and develop chemoresistance. Agents that enhance DDP effectiveness will have a significant impact on cancer treatment.
Ana Paucarmayta, Hannah Taitz, Latoya McGlorthan, Yovanni Casablanca, G. Larry Maxwell, Kathleen M. Darcy, Viqar Syed   +6 more
doaj   +1 more source

Calcitriol Inhibits Viability and Proliferation in Human Malignant Pleural Mesothelioma Cells

Frontiers in Endocrinology, 2020
Malignant pleural mesothelioma (MPM) is a rare and aggressive tumor, often associated with exposure to asbestos and characterized by poor prognosis and limited treatment options.
Iacopo Gesmundo, Francesca Silvagno, Dana Banfi, Valentina Monica, Valentina Monica, Alessandro Fanciulli, Giacomo Gamba, Noemi Congiusta, Roberta Libener, Chiara Riganti, Ezio Ghigo, Riccarda Granata   +11 more
doaj   +1 more source

Bioconversion of vitamin D3 to bioactive calcifediol and calcitriol as high-value compounds

Biotechnology for Biofuels and Bioproducts, 2022
Biological catalysis is an important approach for the production of high-value-added compounds, especially for products with complex structures. Limited by the complex steps of chemical synthesis and low yields, the bioconversion of vitamin D3 (VD3) to ...
Zheyi Wang, Yan Zeng, Hongmin Jia, Niping Yang, Mengshuang Liu, Mingyue Jiang, Yanning Zheng   +6 more
doaj   +1 more source

1,25-OH2 vitamin D3 and AKT-inhibition increase glucocorticoid induced apoptosis in a model of T-cell acute lymphoblastic leukemia (ALL)

Leukemia Research Reports, 2018
In acute lymphoblastic leukemia (ALL), steroid resistance and hypovitaminosis D are both associated with a poor prognosis. We show that methylprednisolone, calcitriol and the AKT-inhibitor MK-2206 have a synergistic effect on the apoptosis of steroid ...
Maximilian Pistor, Lisa Schrewe, Steffen Haupeltshofer, Andrei Miclea, Simon Faissner, Andrew Chan, Robert Hoepner   +6 more
doaj   +1 more source

Therapeutic effects of vitamin D on acetic acid-induced colitis in rats [PDF]

Acta Cirúrgica Brasileira, 2020
Purpose To analyze the effect of calcitriol treatment on acute colitis in an experimental rat model. Methods A total of 24 adult Sprague Dawley albino rats were randomly separated into 3 equal groups: control group (n:8), colitis group (n:8 ...
Refik Bademci, Mümin Alper Erdoğan, Ali Yücel Kara, Gürkan Yiğittürk, Oytun Erbaş   +4 more
doaj   +1 more source

Budesonide and Calcitriol Synergistically Inhibit Airway Remodeling in Asthmatic Mice

Canadian Respiratory Journal, 2018
Background and Objective. While calcitriol can inhibit airway remodeling in asthmatic mice, the mechanism remains unclear. The purpose of this study was to explore the mechanism of action of calcitriol on airway remodeling in asthma and its interaction ...
Jun Qian, Yaqin Xu, Zhiwei Yu
doaj   +1 more source

Hypercalcemia in Lung Cancer due to Simultaneously Elevated PTHrP and Ectopic Calcitriol Production: First Case Report

Case Reports in Oncological Medicine, 2017
Calcitriol-mediated hypercalcemia has been reported in malignant lymphomas and granulomatous diseases but not in lung carcinoma. We describe a patient with squamous cell lung carcinoma with hypercalcemia and elevated calcitriol levels.
Saed Nemr, Sunitha Alluri, Dhivya Sundaramurthy, Daniel Landry, Gregory Braden   +4 more
doaj   +1 more source