Results 21 to 30 of about 25,694 (210)

Induction of the Vitamin D Receptor Attenuates Autophagy Dysfunction-Mediated Cell Death Following Traumatic Brain Injury

Cellular Physiology and Biochemistry, 2017
Background/Aims: Traumatic brain injury (TBI) is a major public health problem in the world and causes high rates of mortality and disability. Recent evidence suggests that vitamin D (VD) has neuroprotective actions and can promote function recovery ...
Changmeng Cui, Jianzhong Cui, Feng Jin, Ying Cui, Ran Li, Xiaohua Jiang, Yanxia Tian, Kaijie Wang, Pei Jiang, Junling Gao   +9 more
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Calcitriol Inhibits Viability and Proliferation in Human Malignant Pleural Mesothelioma Cells

Frontiers in Endocrinology, 2020
Malignant pleural mesothelioma (MPM) is a rare and aggressive tumor, often associated with exposure to asbestos and characterized by poor prognosis and limited treatment options.
Iacopo Gesmundo, Francesca Silvagno, Dana Banfi, Valentina Monica, Valentina Monica, Alessandro Fanciulli, Giacomo Gamba, Noemi Congiusta, Roberta Libener, Chiara Riganti, Ezio Ghigo, Riccarda Granata   +11 more
doaj   +1 more source

1,25-OH2 vitamin D3 and AKT-inhibition increase glucocorticoid induced apoptosis in a model of T-cell acute lymphoblastic leukemia (ALL)

Leukemia Research Reports, 2018
In acute lymphoblastic leukemia (ALL), steroid resistance and hypovitaminosis D are both associated with a poor prognosis. We show that methylprednisolone, calcitriol and the AKT-inhibitor MK-2206 have a synergistic effect on the apoptosis of steroid ...
Maximilian Pistor, Lisa Schrewe, Steffen Haupeltshofer, Andrei Miclea, Simon Faissner, Andrew Chan, Robert Hoepner   +6 more
doaj   +1 more source

Calcitriol Suppresses Warburg Effect and Cell Growth in Human Colorectal Cancer Cells

Life, 2021
Increasing lines of evidence indicate that the biologically active form of vitamin D, calcitriol (1,25-dihydroxyvitamin D3), prevents cancer progression by reducing cell proliferation, increasing cell differentiation, and inhibiting angiogenesis, among ...
Chun-Yin Huang, Yu-Ting Weng, Po-Chen Li, Nien-Tsu Hsieh, Chun-I Li, Hsiao-Sheng Liu, Ming-Fen Lee   +6 more
doaj   +1 more source

TGF-β1 stimulation and VDR-dependent activation modulate calcitriol action on skeletal muscle fibroblasts and Smad signalling-associated fibrogenesis

Scientific Reports, 2023
Fibroblasts play a pivotal role in fibrogenesis after skeletal muscle injury. Excess fibrous formation can disrupt contractile functions and delay functional recovery.
Ratchakrit Srikuea, Muthita Hirunsai
doaj   +1 more source

Hypercalcemia in Lung Cancer due to Simultaneously Elevated PTHrP and Ectopic Calcitriol Production: First Case Report

Case Reports in Oncological Medicine, 2017
Calcitriol-mediated hypercalcemia has been reported in malignant lymphomas and granulomatous diseases but not in lung carcinoma. We describe a patient with squamous cell lung carcinoma with hypercalcemia and elevated calcitriol levels.
Saed Nemr, Sunitha Alluri, Dhivya Sundaramurthy, Daniel Landry, Gregory Braden   +4 more
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Bioconversion of vitamin D3 to bioactive calcifediol and calcitriol as high-value compounds

Biotechnology for Biofuels and Bioproducts, 2022
Biological catalysis is an important approach for the production of high-value-added compounds, especially for products with complex structures. Limited by the complex steps of chemical synthesis and low yields, the bioconversion of vitamin D3 (VD3) to ...
Zheyi Wang, Yan Zeng, Hongmin Jia, Niping Yang, Mengshuang Liu, Mingyue Jiang, Yanning Zheng   +6 more
doaj   +1 more source

Therapeutic effects of vitamin D on acetic acid-induced colitis in rats [PDF]

Acta Cirúrgica Brasileira, 2020
Purpose To analyze the effect of calcitriol treatment on acute colitis in an experimental rat model. Methods A total of 24 adult Sprague Dawley albino rats were randomly separated into 3 equal groups: control group (n:8), colitis group (n:8 ...
Refik Bademci, Mümin Alper Erdoğan, Ali Yücel Kara, Gürkan Yiğittürk, Oytun Erbaş   +4 more
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Anti-Tumor Effects of Ginsenoside 20(S)-Protopanaxadiol and 1,25-Dihydroxyvitamin D3 Combination in Castration Resistant Prostate Cancer

Medicines, 2021
In spite of possessing desirable anticancer properties, currently, limited clinical success has been achieved with 20(S)-protopanaxadiol (aPPD) and 1,25-dihydroxyvitamin D3 (calcitriol).
Mohamed Ben-Eltriki, Subrata Deb, Gehana Shankar, Gray Meckling, Mohamed Hassona, Takeshi Yamazaki, Ladan Fazli, Mei Yieng Chin, Emma S. Tomlinson Guns   +8 more
doaj   +1 more source

Effect of calcitriol on bone turnover and osteocalcin in recent-onset type 1 diabetes

, 2013
Contains fulltext : 125353.pdf (Publisher’s version ) (Open Access)BACKGROUND: Vitamin D supplementation in childhood improves the achievement of peak bone mass.
Crinò, A, Napoli N, Strollo R, Maurizi, Ar, Anguissola, Gb, Benevento, D, Rocky Strollo, Moretti, C, Paolo Pozzilli, Napoli, N, Maggi, D., CAVALLO, Maria Gisella, Carla Bizzarri, Portuesi, R, Cassone Faldetta, Mr, Cipponeri, E, Astorri, E, Manfrini, S, Schwartz, A., Guglielmi, C, Matteoli, Mc, Maddaloni, E., BUZZETTI, Raffaella, Pozzilli, P., Bizzarri, C., et al., Grp, IMDIAB, Spera, S, Pitocco, D, Ghirlanda, G, Di Stasio, E, Beretta Anguissola, G, Ernesto Maddaloni, Ann Schwartz, Maggi, D, Valente, L., Strollo, R, Cipolloni, L, BARCHETTA, ILARIA, Silvia Manfrini, Maddaloni, E, Lauria, A, Nicola Napoli, Bizzarri, C, Manfrini, S., Collaborators, IMDIAB Group, Pozzilli, P, Strollo, R., Capizzi, M, Daria Maggi, Dario Pitocco, Napoli, N., IMDIAB Group, Schwartz, A, Palermo, A, Fioriti, E, Cappa, M, Tuccinardi, D, Pitocco, D.   +57 more
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