Results 21 to 30 of about 27,436 (194)

Association of Calcitriol Supplementation with Reduced COVID-19 Mortality in Patients with Chronic Kidney Disease: A Population-Based Study

Biomedicines, 2021
Treatment with calcitriol, the hormonal form of vitamin D, has shown beneficial effects in experimental models of acute lung injury. In this study, we aimed to analyze the associations between calcitriol supplementation and the risk of SARS-CoV2 ...
Joaquim Oristrell, Joan Carles Oliva, Isaac Subirana, Enrique Casado, Didier Domínguez, Andrea Toloba, Patricia Aguilera, Joan Esplugues, Pilar Fafián, Maria Grau   +9 more
doaj   +1 more source

Impact of calcitriol and an AKT inhibitor, AT7867, on survival of rat C6 glioma cells

Biotechnology & Biotechnological Equipment, 2021
Glioma is the most prevalent and lethal type of primary tumor of central nervous system. The regulatory role of calcitriol, the active form of vitamin D3, has been determined in various cellular processes including cell survival and apoptosis.
Ozlem Kucukhuseyin, Aris Cakiris, Mehmet Tolgahan Hakan, Cem Horozoglu, Erdem Tuzun, Ilhan Yaylim   +5 more
doaj   +1 more source

Mitochondrial potassium channels: A novel calcitriol target

Cellular & Molecular Biology Letters, 2022
Background Calcitriol (an active metabolite of vitamin D) modulates the expression of hundreds of human genes by activation of the vitamin D nuclear receptor (VDR).
Anna M. Olszewska, Adam K. Sieradzan, Piotr Bednarczyk, Adam Szewczyk, Michał A. Żmijewski   +4 more
doaj   +1 more source

Peptide receptor radionuclide therapy controls inappropriate calcitriol secretion in a pancreatic neuro-endocrine tumor: a case report

BMC Gastroenterology, 2020
Background Hypercalcemia of malignancy is not uncommon in patients with advanced stage cancer. In rare cases the cause of the hypercalcemia is excessive production of calcitriol, the active form of vitamin D.
Maarten Haemels, Thierry Delaunoit, Koen Van Laere, Eric Van Cutsem, Chris Verslype, Christophe M. Deroose   +5 more
doaj   +1 more source

The ERRα–VDR axis promotes calcitriol degradation and estrogen signaling in breast cancer cells, while VDR‐CYP24A1‐ERRα overexpression correlates with poor prognosis in patients with basal‐like breast cancer

Molecular Oncology, 2022
Vitamin D is used to reduce cancer risk and improve the outcome of cancer patients, but the vitamin D receptor (VDR; also known as the calcitriol receptor) pathway needs to be functionally intact to ensure the biological effects of circulating calcitriol,
Katia Danza, Letizia Porcelli, Simona De Summa, Roberta Di Fonte, Brunella Pilato, Rosanna Lacalamita, Simona Serratì, Amalia Azzariti, Stefania Tommasi   +8 more
doaj   +1 more source

Calcitriol imparts neuroprotection in vitro to midbrain dopaminergic neurons by upregulating GDNF expression [PDF]

, 2013
During development a tightly controlled signaling cascade dictates the differentiation, maturation and survival of developing neurons. Understanding this signaling mechanism is important for developing therapies for neurodegenerative illnesses.
Ormerod
core   +3 more sources

Hypophosphataemia following iron infusion: a narrative review of an increasingly recognised complication. [PDF]

Intern Med J
Abstract Parenteral iron is widely prescribed by medical practitioners, with more than 600 000 outpatient prescriptions dispensed in 2025 through the Australian Pharmaceutical Benefits Scheme. While intravenous iron has transformed the management of iron deficiency, hypophosphataemia is now recognised as a common complication, with incidences reported ...
Ta B, Baddock S, Ludington J, Sheu A.
europepmc   +2 more sources

Astemizole synergizes calcitriol antiproliferative activity by inhibiting CYP24A1 and upregulating VDR: a novel approach for breast cancer therapy. [PDF]

PLoS ONE, 2012
Calcitriol antiproliferative effects include inhibition of the oncogenic ether-à-go-go-1 potassium channel (Eag1) expression, which is necessary for cell cycle progression and tumorigenesis.
Janice García-Quiroz, Rocío García-Becerra, David Barrera, Nancy Santos, Euclides Avila, David Ordaz-Rosado, Mariana Rivas-Suárez, Ali Halhali, Pamela Rodríguez, Armando Gamboa-Domínguez, Heriberto Medina-Franco, Javier Camacho, Fernando Larrea, Lorenza Díaz   +13 more
doaj   +1 more source

Novel Insights into the Cardioprotective Effects of Calcitriol in Myocardial Infarction

Cells, 2022
Background: Increasing evidence indicates that vitamin D deficiency negatively affects the cardiovascular system. Here we studied the therapeutic effects of calcitriol in myocardial infarction (MI) and investigated its underlying mechanisms.
Simin Yang, Chunmiao Wang, Chengshao Ruan, Meiling Chen, Ran Cao, Liang Sheng, Naiying Chang, Tong Xu, Peiwen Zhao, Xuesheng Liu, Fengqin Zhu, Qingzhong Xiao, Shan Gao   +12 more
doaj   +1 more source

Effect of calcitriol on bone turnover and osteocalcin in recent-onset type 1 diabetes [PDF]

, 2013
Contains fulltext : 125353.pdf (Publisher’s version ) (Open Access)BACKGROUND: Vitamin D supplementation in childhood improves the achievement of peak bone mass.
Crinò, A, Napoli N, Strollo R, Maurizi, Ar, Anguissola, Gb, Benevento, D, Rocky Strollo, Moretti, C, Paolo Pozzilli, Napoli, N, Maggi, D., CAVALLO, Maria Gisella, Carla Bizzarri, Portuesi, R, Cassone Faldetta, Mr, Cipponeri, E, Astorri, E, Manfrini, S, Schwartz, A., Guglielmi, C, Matteoli, Mc, Maddaloni, E., BUZZETTI, Raffaella, Pozzilli, P., Bizzarri, C., et al., Grp, IMDIAB, Spera, S, Pitocco, D, Ghirlanda, G, Di Stasio, E, Beretta Anguissola, G, Ernesto Maddaloni, Ann Schwartz, Maggi, D, Valente, L., Strollo, R, Cipolloni, L, BARCHETTA, ILARIA, Silvia Manfrini, Maddaloni, E, Lauria, A, Nicola Napoli, Bizzarri, C, Manfrini, S., Collaborators, IMDIAB Group, Pozzilli, P, Strollo, R., Capizzi, M, Daria Maggi, Dario Pitocco, Napoli, N., IMDIAB Group, Schwartz, A, Palermo, A, Fioriti, E, Cappa, M, Tuccinardi, D, Pitocco, D.   +57 more
core   +2 more sources