Results 11 to 20 of about 27,436 (194)

Budesonide and Calcitriol Synergistically Inhibit Airway Remodeling in Asthmatic Mice

Canadian Respiratory Journal, 2018
Background and Objective. While calcitriol can inhibit airway remodeling in asthmatic mice, the mechanism remains unclear. The purpose of this study was to explore the mechanism of action of calcitriol on airway remodeling in asthma and its interaction ...
Jun Qian, Yaqin Xu, Zhiwei Yu
doaj   +3 more sources

Calcitriol is involved in maintaining primordial follicle reserve through the inhibition of the PI3K/Akt signaling pathway [PDF]

Journal of Ovarian Research
Background In mammals, precise regulation of primordial follicle activation is essential for maintaining the female reproductive lifespan. In this study, we demonstrated that the vitamin D receptor (VDR) is expressed in both pre-granulosa cells and ...
Shuang Liu, Ye Chen, Hongwei Wei, Huiyu Liu, Weiyong Wang, Yanli Sun, Luchun Zhang, Sihui He, Xiaodan Zhang, Jingjie Li, Meijia Zhang   +10 more
doaj   +2 more sources

Protective role of calcitriol in PM2.5-induced apoptosis and inflammation in bronchial epithelial cells in vitro via vitamin D receptor-mediated Nrf2 signaling [PDF]

Current Research in Toxicology
PM2.5 contributes to lung injury by inducing oxidative stress, inflammatory responses, and apoptosis. Calcitriol exerts a protective role against lung injury by regulating the vitamin D receptor (VDR) and Nrf2 signaling pathways, mitigating PM2.5-induced
Mutita Pluempreecha, Anyamanee Chatsirisupachai, Tanyapohn Soingam, Tasanee Onkoksoong, Tongchai Payungwong, Siwanon Jirawatnotai, Uraiwan Panich   +6 more
doaj   +2 more sources

Immunomodulatory mechanisms of action of calcitriol in psoriasis

Indian Journal of Dermatology, 2014
Background: Calcitriol is well known for its therapeutic efficacy in psoriasis, but its mechanism of action is still unclear. In this study, we tried to elucidate the precise mechanism of calcitriol for its therapeutic efficacy in psoriasis.
Suravi Raychaudhuri, Anupam Mitra, Ananya Datta-Mitra   +2 more
doaj   +2 more sources

Calcitriol attenuates diethylnitrosamine-induced hepatic fibrosis in rats by reducing oxidative stress and fibrogenic mediators. [PDF]

PLoS ONE
Vitamin D deficiency is associated with poor outcomes and increased mortality in cirrhosis. Calcitriol, the active form of vitamin D3, has antioxidant and hepatoprotective properties; however, its effects on diethylnitrosamine (DEN)-induced liver ...
Komsan Arramrak, Namthip Witayavanitkul, Maneerat Chayanupatkul, Natcha Wanpiyarat, Prasong Siriviriyakul, Duangporn Werawatganon   +5 more
doaj   +2 more sources

Management of osteoporosis with calcitriol in elderly Chinese patients: a systematic review

Clinical Interventions in Aging, 2014
Ruo-xi Liao, Miao Yu, Yan Jiang, Weibo XiaDepartment of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, and Chinese Academy of Medical Sciences, Beijing, People's Republic of ChinaAbstract ...
Liao RX, Yu M, Jiang Y, Xia WB
doaj   +1 more source

Inmunoregulación mediada por Calcitriol

Revista de la Facultad de Medicina, 2000
El papel clásico endocrino del calcitriol (la, 25-dihidroxivitamina D3) en la homeóstasis del calcio es bien conocido. Los hallazgos relativamente recientes de la presencia del receptor de calcitriol en monocitos, linfocitos y diversas líneas celulares,
Alberto Pinzón, Adriana Bermeo, Jean Paul Vernot   +2 more
doaj   +2 more sources

Downregulating CHI3L2 via the STAT3 Pathway: The Mechanism of Calcitriol in Suppressing Psoriatic Inflammation and Keratinocyte Hyperproliferation. [PDF]

J Cell Mol Med
ABSTRACT Psoriasis is a chronic inflammatory skin disorder driven by immune dysregulation and keratinocyte hyperproliferation. Calcitriol, the active form of vitamin D, shows therapeutic potential, but its molecular mechanisms remain incompletely understood. CHI3L2 (chitinase‐3‐like protein 2) is a member of the chitinase‐like protein family implicated
He Q, Liu J.
europepmc   +2 more sources

Calcitriol-Loaded Multifunctional Nanospheres with Superlubricity for Advanced Osteoarthritis Treatment

, 2023
Osteoarthritis (OA) is characterized by the lubrication dysfunction of a cartilage sliding interface caused by chronic joint inflammation, and effective nonsurgical therapy for advanced OA remains lacking.
Huiwen Lu (16383797), Wenhua Li (426756), Chao Xie (524756), Yu Dong (398252), Zhanpeng Liu (16383803), Jinhao Cheng (16383800), Lijun Lin (289688), Qili Sun (15265256), Zhaowei Lin (6018188), Kai Li (205203), Jie Qi (53195), Bin Tang (56654)   +11 more
core   +3 more sources

Head-to-head comparison of tazarotene and calcitriol with or without sequential therapy in mild-to-moderate psoriasis: A randomized open-label study

Journal of Research in Pharmacy Practice, 2023
Objective: Psoriasis is an autoimmune disease that causes rapid turnover of skin cells. It is a chronic disease that affects a patient's quality of life significantly and frequently requires long-term treatment.
Jaspreet Kaur Sidhu, Prithpal Singh Matreja, Ashwani Kumar Gupta, Amandeep Singh, Surjit Singh   +4 more
doaj   +1 more source