Results 11 to 20 of about 21,845 (162)

Novel Insights into the Cardioprotective Effects of Calcitriol in Myocardial Infarction

Cells, 2022
Background: Increasing evidence indicates that vitamin D deficiency negatively affects the cardiovascular system. Here we studied the therapeutic effects of calcitriol in myocardial infarction (MI) and investigated its underlying mechanisms.
Simin Yang, Chunmiao Wang, Chengshao Ruan, Meiling Chen, Ran Cao, Liang Sheng, Naiying Chang, Tong Xu, Peiwen Zhao, Xuesheng Liu, Fengqin Zhu, Qingzhong Xiao, Shan Gao   +12 more
doaj   +1 more source

Association of High Calcitriol Serum Levels and Its Hydroxylation Efficiency Ratio with Disease Risk in SLE Patients with Vitamin D Deficiency

Journal of Immunology Research, 2021
Vitamin D (calcidiol) deficiency in systemic lupus erythematosus (SLE) is more frequent than in healthy subjects (HS); it is associated with clinical activity and damage in SLE.
Mónica R. Meza-Meza, José Francisco Muñoz-Valle, Adolfo I. Ruiz-Ballesteros, Barbara Vizmanos-Lamotte, Isela Parra-Rojas, Erika Martínez-López, Edith Oregon-Romero, Yolanda Fabiola Márquez-Sandoval, Sergio Cerpa-Cruz, Ulises de la Cruz-Mosso   +9 more
doaj   +1 more source

Calcitriol confers neuroprotective effects in traumatic brain injury by activating Nrf2 signaling through an autophagy-mediated mechanism

Molecular Medicine, 2021
Background The present study aimed to further explore the potential interaction between oxidative stress and autophagy in the progression of traumatic brain injury (TBI) and therapeutic mechanism of calcitriol, the active form of vitamin D (VitD ...
Changmeng Cui, Changshui Wang, Feng Jin, Mengqi Yang, Lingsheng Kong, Wenxiu Han, Pei Jiang   +6 more
doaj   +1 more source

Calcitriol-enhanced autophagy in gingival epithelium attenuates periodontal inflammation in rats with type 2 diabetes mellitus

Frontiers in Endocrinology, 2023
Type 2 diabetes mellitus (T2DM)-associated periodontitis is a common disease with high prevalence, associated with persistent infection and complicated manifestations.
Yanan Wang, Maoting Huang, Wanlin Xu, Fulong Li, Chunliang Ma, Xiaolin Tang   +5 more
doaj   +1 more source

Induction of the Vitamin D Receptor Attenuates Autophagy Dysfunction-Mediated Cell Death Following Traumatic Brain Injury

Cellular Physiology and Biochemistry, 2017
Background/Aims: Traumatic brain injury (TBI) is a major public health problem in the world and causes high rates of mortality and disability. Recent evidence suggests that vitamin D (VD) has neuroprotective actions and can promote function recovery ...
Changmeng Cui, Jianzhong Cui, Feng Jin, Ying Cui, Ran Li, Xiaohua Jiang, Yanxia Tian, Kaijie Wang, Pei Jiang, Junling Gao   +9 more
doaj   +1 more source

RETRACTED: Progesterone-Calcitriol Combination Enhanced Cytotoxicity of Cisplatin in Ovarian and Endometrial Cancer Cells In Vitro

Biomedicines, 2020
Initially, patients that respond to cisplatin (DDP) treatment later relapse and develop chemoresistance. Agents that enhance DDP effectiveness will have a significant impact on cancer treatment.
Ana Paucarmayta, Hannah Taitz, Latoya McGlorthan, Yovanni Casablanca, G. Larry Maxwell, Kathleen M. Darcy, Viqar Syed   +6 more
doaj   +1 more source

Calcitriol Inhibits Viability and Proliferation in Human Malignant Pleural Mesothelioma Cells

Frontiers in Endocrinology, 2020
Malignant pleural mesothelioma (MPM) is a rare and aggressive tumor, often associated with exposure to asbestos and characterized by poor prognosis and limited treatment options.
Iacopo Gesmundo, Francesca Silvagno, Dana Banfi, Valentina Monica, Valentina Monica, Alessandro Fanciulli, Giacomo Gamba, Noemi Congiusta, Roberta Libener, Chiara Riganti, Ezio Ghigo, Riccarda Granata   +11 more
doaj   +1 more source

1,25-OH2 vitamin D3 and AKT-inhibition increase glucocorticoid induced apoptosis in a model of T-cell acute lymphoblastic leukemia (ALL)

Leukemia Research Reports, 2018
In acute lymphoblastic leukemia (ALL), steroid resistance and hypovitaminosis D are both associated with a poor prognosis. We show that methylprednisolone, calcitriol and the AKT-inhibitor MK-2206 have a synergistic effect on the apoptosis of steroid ...
Maximilian Pistor, Lisa Schrewe, Steffen Haupeltshofer, Andrei Miclea, Simon Faissner, Andrew Chan, Robert Hoepner   +6 more
doaj   +1 more source

Bioconversion of vitamin D3 to bioactive calcifediol and calcitriol as high-value compounds

Biotechnology for Biofuels and Bioproducts, 2022
Biological catalysis is an important approach for the production of high-value-added compounds, especially for products with complex structures. Limited by the complex steps of chemical synthesis and low yields, the bioconversion of vitamin D3 (VD3) to ...
Zheyi Wang, Yan Zeng, Hongmin Jia, Niping Yang, Mengshuang Liu, Mingyue Jiang, Yanning Zheng   +6 more
doaj   +1 more source

Calcitriol Suppresses Warburg Effect and Cell Growth in Human Colorectal Cancer Cells

Life, 2021
Increasing lines of evidence indicate that the biologically active form of vitamin D, calcitriol (1,25-dihydroxyvitamin D3), prevents cancer progression by reducing cell proliferation, increasing cell differentiation, and inhibiting angiogenesis, among ...
Chun-Yin Huang, Yu-Ting Weng, Po-Chen Li, Nien-Tsu Hsieh, Chun-I Li, Hsiao-Sheng Liu, Ming-Fen Lee   +6 more
doaj   +1 more source