Results 1 to 10 of about 49,123 (214)

The molecular, temporal and region-specific requirements of the beta isoform of Calcium/Calmodulin-dependent protein kinase type 2 (CAMK2B) in mouse locomotion. [PDF]

Sci Rep, 2016
AbstractGenetic approaches using temporal and brain region-specific restricted gene deletions have provided a wealth of insight in the brain regions and temporal aspects underlying spatial and associative learning. However, for locomotion such extensive studies are still scarce.
Kool MJ, van de Bree JE, Bodde HE, Elgersma Y, van Woerden GM.   +4 more
europepmc   +5 more sources

Upregulated TRPM1 is associated with apoptosis in Rs1 knockout mice and in ARPE19 cells through increased intracellular calcium [PDF]

Scientific Reports
The pathological mechanism underlying retinal apoptosis in X-linked retinoschisis (XLRS), a disease caused by retinoschisin 1 (RS1) deficiency, remains incompletely understood.
Weiping Wang, Jingyang Liu, Xiuxiu Jin, Ruiqi Qiu, Mingzhu Yang, Shun Yao, Guangming Liu, Mingyang Qin, Bo Lei   +8 more
doaj   +2 more sources

Activation of cGMP-dependent protein kinase stimulates cardiac ATP-sensitive potassium channels via a ROS/calmodulin/CaMKII signaling cascade. [PDF]

PLoS ONE, 2011
Cyclic GMP (cGMP)-dependent protein kinase (PKG) is recognized as an important signaling component in diverse cell types. PKG may influence the function of cardiac ATP-sensitive potassium (K(ATP)) channels, an ion channel critical for stress adaptation ...
Yongping Chai, Dai-Min Zhang, Yu-Fung Lin   +2 more
doaj   +1 more source

Decreased MARCKS Protein Expression in Kidney Cortex Membrane Fractions of Cathepsin B Knockout Mice Is Associated with Reduced Lysophosphatidylcholine and Protein Kinase C Activity

Biomedicines, 2023
Cathpesin B is a multi-functional protease that plays numerous roles in physiology and pathophysiology. We hypothesized that actin cytoskeleton proteins that are substrates of cathepsin B, various lipids, and kinases that are regulated by lipids would be
Tamim Kawakibi, Niharika Bala, Lauren P. Liu, Louis A. Searcy, Nancy D. Denslow, Abdel A. Alli   +5 more
doaj   +1 more source

Calcium-calmodulin-dependent protein kinase type 2 induces apoptosis of hepatocytes after liver transplantation.

European review for medical and pharmacological sciences, 2020
The warm ischemia-reperfusion injury confines the prevalence of allografts. To improve the success rate of allotransplantation, we designed experiments to study the mechanism of calcium-calmodulin-dependent protein kinase type 2 (CaMK II) in ischemia-reperfusion (I/R) injury.We established the I/R model in SD rats and performed the liver ...
Li, W., Zhang, X.-B., Wu, R.-C., Zhang, S.-N., Liu, J., Gao, Y., Zheng, K.-P., Ran, J.-H.   +7 more
openaire   +2 more sources

Methionine sulfoxide reductase B3 deficiency inhibits the development of diet-induced insulin resistance in mice

Redox Biology, 2021
Oxidative and endoplasmic reticulum (ER) stress are involved in mediating high-fat diet (HFD)-induced insulin resistance. As the ER-localized methionine sulfoxide reductase B3 (MsrB3) protects cells against oxidative and ER stress, we hypothesized that ...
Hye-Na Cha, Chang-Hoon Woo, Hwa-Young Kim, So-Young Park   +3 more
doaj   +1 more source

Expression of Calcium/Calmodulin-Dependent Protein Kinase II and Pain-Related Behavior in Rat Models of Type 1 and Type 2 Diabetes

Anesthesia & Analgesia, 2013
Abnormalities in peripheral nerves and dorsal root ganglia are noticed in the early stage of experimentally provoked diabetic neuropathy. Enzyme calcium/calmodulin-dependent protein kinase II (CaMKII) may have a modulating role in diabetic neuropathy because of its role in calcium homeostasis.A model of type 1 diabetes mellitus (DM1) was induced with ...
Ferhatović, Lejla, Banožić, Adriana, Kostić, Sandra, Tičinović Kurir, Tina, Novak, Anela, Vrdoljak, Luka, Heffer, Marija, Sapunar, Damir, Puljak, Livia   +8 more
openaire   +4 more sources

Adipocyte CAMK2 deficiency improves obesity-associated glucose intolerance

Molecular Metabolism, 2021
Objective: Obesity-related adipose tissue dysfunction has been linked to the development of insulin resistance, type 2 diabetes, and cardiovascular disease.
Wen Dai, Mayank Choubey, Sonal Patel, Harold A. Singer, Lale Ozcan   +4 more
doaj   +1 more source

TRPV1 Activation by Capsaicin Mediates Glucose Oxidation and ATP Production Independent of Insulin Signalling in Mouse Skeletal Muscle Cells

Cells, 2021
Background: Insulin resistance (IR), a key characteristic of type 2 diabetes (T2DM), is manifested by decreased insulin-stimulated glucose transport in target tissues.
Parisa Vahidi Ferdowsi, Kiran D. K. Ahuja, Jeffrey M. Beckett, Stephen Myers   +3 more
doaj   +1 more source

Serotonin 5-HT3 receptor-mediated vomiting occurs via the activation of Ca2+/CaMKII-dependent ERK1/2 signaling in the least shrew (Cryptotis parva). [PDF]

PLoS ONE, 2014
Stimulation of 5-HT3 receptors (5-HT3Rs) by 2-methylserotonin (2-Me-5-HT), a selective 5-HT3 receptor agonist, can induce vomiting. However, downstream signaling pathways for the induced emesis remain unknown.
Weixia Zhong, Tarun E Hutchinson, Seetha Chebolu, Nissar A Darmani   +3 more
doaj   +1 more source