Results 21 to 30 of about 49,123 (214)

Dataset for diseases associated with exposure to broflanilide, a novel pesticide, in larval zebrafish (Danio rerio)

Data in Brief, 2023
Broflanilide is a novel pesticide that can antagonize ion channels and disrupt neurotransmitter systems in the brain. Zebrafish larvae were exposed to either 0, 1 or 10- µg/L broflanilide in the water for a period of 7 days during early development.
Sarah J. Patuel, Cole English, Victoria Lopez-Scarim, Isaac Konig, Christopher L. Souders, II, Emma Ivantsova, Christopher J. Martyniuk   +6 more
doaj   +1 more source

LIFU Alleviates Neuropathic Pain by Improving the KCC2 Expression and Inhibiting the CaMKIV–KCC2 Pathway in the L4–L5 Section of the Spinal Cord

Neural Plasticity, 2021
Effective treatment remains lacking for neuropathic pain (NP), a type of intractable pain. Low-intensity focused ultrasound (LIFU), a noninvasive, cutting-edge neuromodulation technique, can effectively enhance inhibition of the central nervous system ...
Ye-Hui Liao, Bin Wang, Mo-Xian Chen, Yao Liu, Li-Juan Ao   +4 more
doaj   +1 more source

The RNA editing patterns are different in blood of euthymic and depressed bipolar patients

European Psychiatry, 2023
Introduction Bipolar disorder (BD) is a severe mental disorder associated with functional impairment, high disability and premature mortality. Modifications of editing in mRNA of serotonin receptor subtype 2C (5-HTR2c) was reported by us in depressed ...
M. Hayashi, N. Salvetat, C. Cayzac, F. J. Checa-Robles, C. Lozano, J.-D. Abraham, B. Dubuc, S. Mereuze, J. V. Nani, F. Molina, E. Brietske, D. Weissmann   +11 more
doaj   +1 more source

Delphinidin induces a fast-to-slow muscle fiber type shift through the AMPK signaling pathway in C2C12 myotubes

Biochemistry and Biophysics Reports
Delphinidin, a plant anthocyanidin, suppresses disuse muscle atrophy in mice. However, its effect on muscle fiber type shift is unclear. To examine whether delphinidin affects skeletal muscle fiber type, differentiated C2C12 cells were treated with ...
Motoki Murata, Rina Takahashi, Yuki Marugame, Yoshinori Fujimura, Hirofumi Tachibana   +4 more
doaj   +1 more source

Sleep is enhanced in aged male mice that overexpress calcium/calmodulin-dependent protein kinase IV

Frontiers in Neuroscience
The dysregulation of sleep–wake patterns that occurs during aging is well documented and coincides with changes in intracellular signaling pathways that regulate sleep, such as the calcium/calmodulin-dependent protein kinase (CaMKII)/cyclic-AMP response ...
Sierra P. Feeney, Erin Threlfall, James M. Bilboa, Christopher C. Angelakos, Mathieu E. Wimmer, Satoshi Kida, Ted Abel, Ted Abel, Ted Abel, Jennifer C. Tudor, Jennifer C. Tudor   +10 more
doaj   +1 more source

Hepatocyte DACH1 Is Increased in Obesity via Nuclear Exclusion of HDAC4 and Promotes Hepatic Insulin Resistance

Cell Reports, 2016
Defective insulin signaling in hepatocytes is a key factor in type 2 diabetes. In obesity, activation of calcium/calmodulin-dependent protein kinase II (CaMKII) in hepatocytes suppresses ATF6, which triggers a PERK-ATF4-TRB3 pathway that disrupts insulin
Lale Ozcan, Devram S. Ghorpade, Ze Zheng, Jane Cristina de Souza, Ke Chen, Marc Bessler, Melissa Bagloo, Beth Schrope, Richard Pestell, Ira Tabas   +9 more
doaj   +1 more source

A Brain‐Penetrant Nanobody Reveals GSK3β‐Driven Proline‐Directed Phosphorylation as a Master Regulator of Ischemic Neurodegeneration

Advanced Science, EarlyView.
A brain‐targeted nanoparticle enables delivery of a therapeutic nanobody (Nb.29E9) that inhibits pathogenic GSK3β signaling. This intervention restores AMPK/mTORC1/TGFβ homeostasis, attenuates neuroinflammation and oxidative stress, and promotes long‐term functional recovery after ischemic stroke.
Lan Li, Muyang Li, Lei Sun, Ying Yang, Yuanshun Wu, Ziyi Yin, Anni Wang, Peiyang Zhou, Shaoxiang Luo, Jian Chen, Jun Qin, Zhibing Ai, Zilong Yuan, Zhiqiang Dong, Min Zhang   +14 more
wiley   +1 more source

AMPK and CAMKK activation participate in early events of Toxoplasma gondii-triggered NET formation in bovine polymorphonuclear neutrophils

Frontiers in Veterinary Science
Toxoplasma gondii is an obligate intracellular apicomplexan parasite that infects humans, eventually causing severe diseases like prenatal or ocular toxoplasmosis. T.
Iván Conejeros, Zahady D. Velásquez, Gabriel Espinosa, Lisbeth Rojas-Baron, Magdalena Grabbe, Carlos Hermosilla, Anja Taubert   +6 more
doaj   +1 more source

The glutamatergic system and astrocytic impairment in rat hippocampus: a comparative study of underlying etiology and pathophysiology of depression

Journal of Integrative Neuroscience, 2019
Correlations amongst the rat glutamatergic system, glia, and depression, as well as the underlying mechanism of astrocyte impairment, as a trigger of depression, were investigated.
Shuo Jiang, Quan-ai Zhang, Qin Guo, Zhong Di   +3 more
doaj   +1 more source

An Anterior Cingulate Cortex‐Anterior Insular Cortex Glutamatergic Circuit Gates Stress‐Induced Visceral Hypersensitivity and Anxiety via Ionotropic Glutamate Receptors Trafficking

Advanced Science, EarlyView.
This study identifies an anterior cingulate cortex (ACC) to anterior insular cortex (AIC) glutamatergic (Glu) circuit that gates stress induced visceral hypersensitivity and anxiety. Circuit activation induces both phenotypes, whereas inhibition relieves them.
Junwen Wang, Guangbing Duan, Huihui Sun, Zhiyu Dong, Qiwei Wang, Xiaowei Li, Ying Chen, Shuchang Xu, Ying Huang   +8 more
wiley   +1 more source