Results 1 to 10 of about 51,149 (268)

Differential Distribution of Retinal Ca2+/Calmodulin-Dependent Kinase II (CaMKII) Isoforms Indicates CaMKII-β and -δ as Specific Elements of Electrical Synapses Made of Connexin36 (Cx36) [PDF]

open access: yesFrontiers in Molecular Neuroscience, 2017
AII amacrine cells are essential interneurons of the primary rod pathway and transmit rod-driven signals to ON cone bipolar cells to enable scotopic vision.
Stephan Tetenborg   +7 more
doaj   +5 more sources

Integrated mechanisms of CaMKII-dependent ventricular remodeling

open access: yesFrontiers in Pharmacology, 2014
CaMKII has been shown to be activated during different cardiac pathological processes, and CaMKII-dependent mechanisms contribute to pathological cardiac remodeling, cardiac arrhythmias and contractile dysfunction during heart failure.
Johannes Backs
exaly   +3 more sources

Ser-Thr phosphatases in the rat brain that dephosphorylate phospho-Ser(1291)-GluN2A subunit of glutamate receptor [PDF]

open access: yesThe Ukrainian Biochemical Journal, 2023
N-methyl-D-aspartate receptors (NMDARs), are one of the major ionotropic glutamate receptors found in excitatory synapses which play a key role in glutamatergic synaptic transmission.
R. R. Prabhu
doaj   +1 more source

Aβ-induced synaptic impairments require CaMKII activity that is stimulated by indirect signaling events

open access: yesiScience, 2022
Summary: Aβ bears homology to the CaMKII regulatory domain, and peptides derived from this domain can bind and disrupt the CaMKII holoenzyme, suggesting that Aβ could have a similar effect.
Carolyn Nicole Brown   +4 more
doaj   +1 more source

Exploring Excitotoxicity and Regulation of a Constitutively Active TRP Ca2+ Channel in Drosophila

open access: yesFly, 2021
Unregulated Ca2+ influx affects intracellular Ca2+ homoeostasis, which may lead to neuronal death. In Drosophila, following the activation of rhodopsin the TRP Ca2+ channel is open to mediate the light-dependent depolarization.
Bih-Hwa Shieh   +2 more
doaj   +1 more source

Ca2+/Calmodulin-Dependent Protein Kinase II Inhibits Hepatitis B Virus Replication from cccDNA via AMPK Activation and AKT/mTOR Suppression

open access: yesMicroorganisms, 2022
Ca2+/calmodulin-dependent protein kinase II (CaMKII), which is involved in the calcium signaling pathway, is an important regulator of cancer cell proliferation, motility, growth, and metastasis.
Jumi Kim   +10 more
doaj   +1 more source

Targeting the CaMKII/ERK Interaction in the Heart Prevents Cardiac Hypertrophy. [PDF]

open access: yesPLoS ONE, 2015
Activation of Ca2+/Calmodulin protein kinase II (CaMKII) is an important step in signaling of cardiac hypertrophy. The molecular mechanisms by which CaMKII integrates with other pathways in the heart are incompletely understood.
Ersilia Cipolletta   +15 more
doaj   +1 more source

Locally-Induced CaMKII Translocation Requires Nucleotide Binding

open access: yesFrontiers in Synaptic Neuroscience, 2020
Calcium-calmodulin-dependent protein kinase (CaMKII) is a molecule involved in several cell processes including plasticity related to learning and memory. Activation of NMDA-type glutamate receptors results in translocation of CaMKII to synapses. However,
Zachary T. Fitzgerald   +1 more
doaj   +1 more source

Transient Chemogenetic Inhibition of D1-MSNs in the Dorsal Striatum Enhances Methamphetamine Self-Administration

open access: yesBrain Sciences, 2019
The dorsal striatum is important for the development of drug addiction; however, the role of dopamine D1 receptor (D1R) expressing medium-sized spiny striatonigral (direct pathway) neurons (D1-MSNs) in regulating excessive methamphetamine intake remains ...
Robert J. Oliver   +3 more
doaj   +1 more source

CaMKII regulates neuromuscular activity and survival of the human blood fluke Schistosoma mansoni

open access: yesScientific Reports, 2022
Calcium/calmodulin dependant protein kinase II (CaMKII), an important transducer of Ca2+ signals, orchestrates multiple cellular functions in animals.
Natasha L. Hirst   +2 more
doaj   +1 more source

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