Results 31 to 40 of about 51,149 (268)

On the brain of a crustacean: a morphological analysis of CaMKII expression and its relation to sensory and motor pathways. [PDF]

PLoS ONE, 2013
Calcium/calmodulin kinase II (CaMKII) is a Ca(2+)-activated enzyme that is abundant in vertebrate and invertebrate brains. However, its characterization is poorly addressed in the nervous system of crustaceans, and, to our knowledge, no studies have ...
Dib Ammar, Evelise M Nazari, Yara M R Müller, Silvana Allodi   +3 more
doaj   +1 more source

Nonspecific, Reversible Inhibition of Voltage-Gated Calcium Channels by CaMKII Inhibitor CK59 [PDF]

, 2013
Investigation of kinase-related processes often uses pharmacological inhibition to reveal pathways in which kinases are involved. However, one concern about using such kinase inhibitors is their potential lack of specificity.
Kahrls, Andrew S., Mynlieff, Michelle
core   +2 more sources

Role of CaMKII in cardiac arrhythmias [PDF]

Trends in Cardiovascular Medicine, 2015
Protein phosphorylation is a central mechanism in vertebrates for the regulation of signaling. With regard to the cardiovascular system, phosphorylation of myocyte targets is critical for the regulation of excitation contraction coupling, metabolism, intracellular calcium regulation, mitochondrial activity, transcriptional regulation, and cytoskeletal ...
Thomas J, Hund, Peter J, Mohler
openaire   +2 more sources

CaMKII-dependent regulation of cardiac Na(+) homeostasis. [PDF]

, 2014
Na(+) homeostasis is a key regulator of cardiac excitation and contraction. The cardiac voltage-gated Na(+) channel, NaV1.5, critically controls cell excitability, and altered channel gating has been implicated in both inherited and acquired arrhythmias.
Grandi, Eleonora, Herren, Anthony W
core   +2 more sources

Dynamic Kv4.3–CaMKII unit in heart: an intrinsic negative regulator for CaMKII activation [PDF]

European Heart Journal, 2010
Reduction of transient outward current (I(to)) and excessive activation of Ca(2+)/Calmodulin-dependent kinase II (CaMKII) are general features of ventricular myocytes in heart failure. We hypothesize that alterations of I(to) directly regulate CaMKII activation in cardiomyocytes.A dynamic coupling of I(to) channel subunit Kv4.3 and inactive CaMKII was ...
Thitima, Keskanokwong, Hyun Joung, Lim, Peng, Zhang, Jun, Cheng, Lin, Xu, Dongwu, Lai, Yanggan, Wang   +6 more
openaire   +2 more sources

The κ-Opioid Receptor Agonist U50488H Ameliorates Neuropathic Pain Through the Ca2+/CaMKII/CREB Pathway in Rats

Journal of Inflammation Research, 2022
Xiao-Min Zhang, Ming-Hui Lun, Wei Du, Fang Ma, Ze-Qing Huang Department of Anesthesiology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institution, NO.44 Xiaoheyan Road, Dadong District, Shenyang, Liaoning Province, 110042 ...
Zhang XM, Lun MH, Du W, Ma F, Huang ZQ
doaj  

Activation of Orexin System Stimulates CaMKII Expression

Frontiers in Physiology, 2021
Hyperactivity of the orexin system within the paraventricular nucleus (PVN) has been shown to contribute to increased sympathetic nerve activity (SNA) and blood pressure (BP) in rodent animals. However, the underlying molecular mechanisms remain unclear.
Yuanyuan Fan, Yuanyuan Fan, Enshe Jiang, Enshe Jiang, Huanjia Gao, Huanjia Gao, Jeremy Bigalke, Bojun Chen, Chunxiu Yu, Chunxiu Yu, Qinghui Chen, Qinghui Chen, Zhiying Shan, Zhiying Shan   +13 more
doaj   +1 more source

Nuclear CaMKII enhances histone H3 phosphorylation and remodels chromatin during cardiac hypertrophy. [PDF]

, 2013
Calcium/calmodulin-dependent protein kinase II (CaMKII) plays a central role in pathological cardiac hypertrophy, but the mechanisms by which it modulates gene activity in the nucleus to mediate hypertrophic signaling remain unclear. Here, we report that
An, Woojin, Awad, Salma, Bai, Yan, Bers, Donald, Kedes, Larry, Kunhi, Muhammad, Little, Gillian H, Poizat, Coralie   +7 more
core   +1 more source

Metabolic Activation of CaMKII by Coenzyme A [PDF]

Molecular Cell, 2013
Active metabolism regulates oocyte cell death via calcium/calmodulin-dependent protein kinase II (CaMKII)-mediated phosphorylation of caspase-2, but the link between metabolic activity and CaMKII is poorly understood. Here we identify coenzyme A (CoA) as the key metabolic signal that inhibits Xenopus laevis oocyte apoptosis by directly activating ...
McCoy, Francis, Darbandi, Rashid, Lee, Hoi Chang, Bharatham, Kavitha, Moldoveanu, Tudor, Royappa, Grace, Dodd, Keela, Lin, Wenwei, Chen, Si-Ing, Tangallapally, Rajendra P., Kurokawa, Manabu, Lee, Richard E., Shelat, Anang, Chen, Taosheng, Green, Douglas R., Harris, Robert A., Lin, Sue-Hwa, Fissore, Rafael A., Colbran, Roger J., Nutt, Leta K.   +19 more
openaire   +4 more sources

Effects of diet and/or exercise in enhancing spinal cord sensorimotor learning. [PDF]

, 2012
Given that the spinal cord is capable of learning sensorimotor tasks and that dietary interventions can influence learning involving supraspinal centers, we asked whether the presence of omega-3 fatty acid docosahexaenoic acid (DHA) and the curry spice ...
Bhatia, Harsharan S, Cruz, Rusvelda, Edgerton, V Reggie, Gomez-Pinilla, Fernando, Joseph, M Selvan, Roy, Roland R, Tillakaratne, Niranjala JK, Wu, Aiguo, Ying, Zhe, Zhong, Hui, Zhuang, Yumei   +10 more
core   +6 more sources