CaMKII Structure—An Elegant Design [PDF]
Cell, 2005 Crystal structures of protein kinases continue to reveal new mechanisms for the regulation of catalytic activity of these enzymes. In this issue of Cell, Rosenberg et al. (2005) report the structure of the catalytic and regulatory domains of CaMKII, a protein kinase important in the cellular response to changes in intracellular calcium ion ...
Hunter, Tony, Schulman, Howard
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Data_Sheet_1_Localization of Retinal Ca2+/Calmodulin-Dependent Kinase II-β (CaMKII-β) at Bipolar Cell Gap Junctions and Cross-Reactivity of a Monoclonal Anti-CaMKII-β Antibody With Connexin36.pdf [PDF]
, 2019 Neuronal gap junctions formed by connexin36 (Cx36) and chemical synapses share striking similarities in terms of plasticity. Ca2+/calmodulin-dependent protein kinase II (CaMKII), an enzyme known to induce memory formation at chemical synapses, has ...
Geeske M. van Woerden (7320734) +8 more
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Endothelial CaMKII as a regulator of eNOS activity and NO-mediated vasoreactivity. [PDF]
PLoS ONE, 2017 The multifunctional Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a serine/threonine kinase important in transducing intracellular Ca2+ signals.
Shubha Murthy +13 more
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Diabetes increases mortality after myocardial infarction by oxidizing CaMKII [PDF]
, 2013 Diabetes increases oxidant stress and doubles the risk of dying after myocardial infarction, but the mechanisms underlying increased mortality are unknown.
Rokita, Adam G +39 more
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Role of CaMKII in cardiac arrhythmias [PDF]
Trends in Cardiovascular Medicine, 2015 Protein phosphorylation is a central mechanism in vertebrates for the regulation of signaling. With regard to the cardiovascular system, phosphorylation of myocyte targets is critical for the regulation of excitation contraction coupling, metabolism, intracellular calcium regulation, mitochondrial activity, transcriptional regulation, and cytoskeletal ...
Thomas J, Hund, Peter J, Mohler
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On the brain of a crustacean: a morphological analysis of CaMKII expression and its relation to sensory and motor pathways. [PDF]
PLoS ONE, 2013 Calcium/calmodulin kinase II (CaMKII) is a Ca(2+)-activated enzyme that is abundant in vertebrate and invertebrate brains. However, its characterization is poorly addressed in the nervous system of crustaceans, and, to our knowledge, no studies have ...
Dib Ammar +3 more
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CaMKIIα as a Promising Drug Target for Ischemic Grey Matter
Brain Sciences, 2022 Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a major mediator of Ca2+-dependent signaling pathways in various cell types throughout the body.
Nane Griem-Krey +2 more
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Dynamic Kv4.3–CaMKII unit in heart: an intrinsic negative regulator for CaMKII activation [PDF]
European Heart Journal, 2010 Reduction of transient outward current (I(to)) and excessive activation of Ca(2+)/Calmodulin-dependent kinase II (CaMKII) are general features of ventricular myocytes in heart failure. We hypothesize that alterations of I(to) directly regulate CaMKII activation in cardiomyocytes.A dynamic coupling of I(to) channel subunit Kv4.3 and inactive CaMKII was ...
Thitima, Keskanokwong +6 more
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Potential scheme for the Ca2+-CaMKII-CREB signaling pathway that is involved in ES-induced neurite outgrowth and BDNF transcription. [PDF]
, 2016 Potential scheme for the Ca2+-CaMKII-CREB signaling pathway that is involved in ES-induced neurite outgrowth and BDNF transcription.
Xueyu Hu (110540) +7 more
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Inhibition of CaMKII Attenuates Progressing Disruption of Ca2+ Homeostasis Upon Left Ventricular Assist Device Implantation in Human Heart Failure [PDF]
, 2016 In heart failure, left ventricular assist device (LVAD) implantation is performed to ensure sufficient cardiac output. Whereas some patients are subsequently weaned from LVAD support, other patients still need heart transplantation.
Kleinwächter, Astrid +9 more
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