Results 41 to 50 of about 51,149 (268)
CaMKIIalpha interacts with multi-PDZ domain protein MUPP1 in spermatozoa and prevents spontaneous acrosomal exocytosis [PDF]
, 2009 The success of acrosomal exocytosis, a complex process with a variety of inter-related steps, relies on the coordinated interaction of participating signaling molecules.
Ackermann, Frauke +5 more
core +1 more source
UVR Promotes Keratinocyte Phagocytosis and Skin Pigmentation Through TRPA1 Channels
Clinical, Cosmetic and Investigational Dermatology, 2022 Ying Liu,1,* Zhou Li,1,* Wei Wu,1,* Yupeng Wang,1 Guangming Zhao,1 Yuejian Liu,2 Jing Liu,3 Zhiqi Song1 1Department of Dermatology, First Affiliated Hospital of Dalian Medical University, Dalian, People’s Republic of China; 2Central ...
Liu Y +7 more
doaj
C-terminal phosphorylation of NaV1.5 impairs FGF13-dependent regulation of channel inactivation [PDF]
, 2017 International audienceVoltage-gated Na(+) (NaV) channels are key regulators of myocardial excitability, and Ca(2+)/calmodulin-dependent protein kinase II (CaMKII)-dependent alterations in NaV1.5 channel inactivation are emerging as a critical determinant
Brown, Joan H. +11 more
core +2 more sources
Effects of CaMKII inhibitor tatCN21 on activity-dependent redistribution of CaMKII in hippocampal neurons [PDF]
Neuroscience, 2013 TatCN21 is a membrane permeable calcium/calmodulin-dependent protein kinase II (CaMKII) inhibitor derived from the inhibitor protein CaMKIIN. TatCN21 has been used to demonstrate the involvement of CaMKII in a variety of physiological and pathological phenomena, and it also limits excitotoxic damage in neurons.
J-H, Tao-Cheng +4 more
openaire +2 more sources
Molecular Brain, 2009 Background Previous studies have demonstrated essential roles for alpha-calcium/calmodulin-dependent protein kinase II (alpha-CaMKII) in learning, memory and long-term potentiation (LTP).
Hasegawa Shunsuke +13 more
doaj +1 more source
Regulation of the Neuron-specific Ras GTPase-activating Protein, synGAP, by Ca2+/Calmodulin-dependent Protein Kinase II [PDF]
, 2004 synGAP is a neuron-specific Ras GTPase-activating protein found in high concentration in the postsynaptic density fraction from mammalian forebrain. Proteins in the postsynaptic density, including synGAP, are part of a signaling complex attached to the ...
Kennedy, Mary B. +2 more
core +1 more source
The emerging role of CaMKII in cancer
Oncotarget, 2015 Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a multifunctional serine/threonine kinases best known for its critical role in learning and memory. Recent studies suggested that high levels of CaMKII also expressed in variety of malignant diseases. In this review, we focus on the structure and biology properties of CaMKII, including the role of
Yan-yang, Wang, Ren, Zhao, Hong, Zhe
openaire +3 more sources
Architectural Dynamics of CaMKII-Actin Networks [PDF]
Biophysical Journal, 2019 Calcium-calmodulin-dependent kinase II (CaMKII) has an important role in dendritic spine remodeling upon synaptic stimulation. Using fluorescence video microscopy and image analysis, we investigated the architectural dynamics of rhodamine-phalloidin stabilized filamentous actin (F-actin) networks cross-linked by CaMKII. We used automated image analysis
Khan, Shahid +2 more
openaire +2 more sources
Expression of A152T human tau causes age-dependent neuronal dysfunction and loss in transgenic mice. [PDF]
, 2016 A152T-variant human tau (hTau-A152T) increases risk for tauopathies, including Alzheimer's disease. Comparing mice with regulatable expression of hTau-A152T or wild-type hTau (hTau-WT), we find age-dependent neuronal loss, cognitive impairments, and ...
Craft, Ryan +13 more
core +2 more sources
Molecular Brain, 2019 Calcium/Calmodulin-dependent protein kinase II (CaMKII) plays a key role in the molecular mechanism of memory formation. CaMKII is known to be activated specifically in the activated spines during memory formation.
Sanghyun Ye +3 more
doaj +1 more source