Results 51 to 60 of about 33,635 (254)
Molecular Brain, 2019 Calcium/Calmodulin-dependent protein kinase II (CaMKII) plays a key role in the molecular mechanism of memory formation. CaMKII is known to be activated specifically in the activated spines during memory formation.
Sanghyun Ye +3 more
doaj +1 more source
Molecular basis for cellular retinoic acid-binding protein 1 in modulating CaMKII activation
Frontiers in Molecular Biosciences, 2023 Introduction: Cellular retinoic acid (RA)-binding protein 1 (CRABP1) is a highly conserved protein comprised of an anti-parallel, beta-barrel, and a helix-turn-helix segment outside this barrel.
Jennifer Nhieu +4 more
doaj +1 more source
While systolic cardiomyocyte function is preserved, diastolic myocyte function and recovery from acidosis are impaired in CaMKII delta-KO mice [PDF]
, 2013 Objective: CaMKII contributes to impaired contractility in heart failure by inducing SR Ca2+-leak. CaMKII-inhibition in the heart was suggested to be a novel therapeutic principle. Different CaMKII isoforms exist. Specifically targeting CaMKII delta, the
Backs, Johannes +10 more
core +1 more source
Activity-dependent redistribution of CaMKII in the postsynaptic compartment of hippocampal neurons
Molecular Brain, 2020 Calcium/calmodulin-dependent protein kinase II (CaMKII), an abundant protein in neurons, is involved in synaptic plasticity and learning. CaMKII associates with multiple proteins located at or near the postsynaptic density (PSD), and CaMKII is known to ...
Jung-Hwa Tao-Cheng
doaj +1 more source
CaMKII Plays a Nonenzymatic Role in Hippocampal Synaptic Plasticity and Learning by Targeting CaMKII to Synapses [PDF]
, 2011 The calcium/calmodulin-dependent kinase type II (CaMKII) holoenzyme of the forebrain predominantly consists of heteromeric complexes of the beta CaMKII and alpha CaMKII isoforms.
Borgesius, NZ +15 more
core +1 more source
Bistability in the CaMKII Model [PDF]
, 2013 CaMKII-thr286* indicates Thr286-phosphorylated CaMKII, and CaMKII-thr286*-thr305* indicates Thr286/Thr305-phosphorylated CaMKII.(A) Schematic of CaMKII autophosphorylation in the PSD. Reactions (in bold) and PP1 concentrations are altered in the PSD from
Arnold Hayer (275040) +1 more
core +1 more source
Fiyz̤, 2020 Background: Histone Dacetylases-4 (HDAC4) is phosphorylated by calcium-calmodulin-dependent kinase (CaMKII) that plays an important role in cardiac tissue hypertrophy.
Mojdeh Khajehlandi +4 more
doaj
CaMKII is essential for the function of the enteric nervous system. [PDF]
PLoS ONE, 2012 Ca(2+)/calmodulin-dependent protein kinases (CaMKs) are major downstream mediators of neuronal calcium signaling that regulate multiple neuronal functions. CaMKII, one of the key CaMKs, plays a significant role in mediating cellular responses to external
Na Gao +9 more
doaj +1 more source
Pathways for CaMKII activation in disease [PDF]
Heart Rhythm, 2011 The multifunctional Ca2+ and calmodulin-dependent protein kinase II (CaMKII) has emerged as an interesting proarrhythmic and procardiomyopathic signaling molecule with therapeutic potential. The importance of this growing body of evidence showing that CaMKII plays a central role in myocardial disease is evidenced, in part, by this thematic series ...
openaire +2 more sources
NADPH oxidase 2 mediates angiotensin II-dependent cellular arrhythmias via PKA and CaMKII [PDF]
, 2014 Rationale: Angiotensin II (Ang II) signaling has been implicated in cardiac arrhythmogenesis, which involves induction of reactive oxygen species (ROS).
Shah, Ajay M. +11 more
core +1 more source