Results 21 to 30 of about 33,635 (254)
CaMKII in cerebral ischemia [PDF]
Acta Pharmacologica Sinica, 2011 Ischemic insults on neurons trigger excessive, pathological glutamate release that causes Ca²⁺ overload resulting in neuronal cell death (excitotoxicity). The Ca²⁺/calmodulin (CaM)-dependent protein kinase II (CaMKII) is a major mediator of physiological excitatory glutamate signals underlying neuronal plasticity and learning. Glutamate stimuli trigger
Steven J, Coultrap +4 more
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Circulation, 2011 Electrical storm (ES), a medical emergency, is the frequent occurrence of ventricular tachycardia or fibrillation, defined as 3 or more episodes in a 24-hour period. Although ES can occur in a variety of settings, including ischemia, heart failure, and channelopathies, general incidence and awareness of this condition have dramatically risen since the ...
Paari Dominic Swaminathan +1 more
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Influence of immobilization stress on the levels of CaMKII and phospho-CaMKII in the rat hippocampus [PDF]
The International Journal of Neuropsychopharmacology, 2004 The phosphorylation of calcium/calmodulin-dependent protein kinase (CaMK) II, induced by an increase in the intracellular Ca2+ concentration, is involved in the alteration of brain functions such as memory formation. In the present study, we examined the influence of various immobilization stress paradigms on the phosphorylation of CaMKII (phospho ...
Takami, Suenaga +4 more
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Quantitative Proteomics Analysis of CaMKII Phosphorylation and the CaMKII Interactome in the Mouse Forebrain [PDF]
ACS Chemical Neuroscience, 2015 Ca(2+)/calmodulin-dependent protein kinase IIα (CaMKIIα) autophosphorylation at Thr286 and Thr305/Thr306 regulates kinase activity and modulates subcellular targeting and is critical for normal synaptic plasticity and learning and memory. Here, a mass spectrometry-based approach was used to identify Ca(2+)-dependent and -independent in vitro ...
Baucum, Anthony J. +3 more
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Pathological activation of CaMKII induces arrhythmogenicity through TRPM4 overactivation. [PDF]
, 2021 TRPM4 is a Ca2+-activated nonselective cation channel involved in cardiovascular physiology and pathophysiology. Based on cellular experiments and numerical simulations, the present study aimed to explore the potential arrhythmogenicity of CaMKII ...
Ross Kaschitza, Daniela +6 more
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Molecules for memory: modelling CaMKII [PDF]
BMC Systems Biology, 2007 Long-term modifications of synaptic strength, such aslong-term potentiation (LTP) or long-term depression(LTD) are thought to underlie some forms of learning andmemory. At the excitatory glutamate synapse, LTP isdependent on calcium influx through the N-methyl-D-aspartate (NMDA) receptor and subsequent activation ofcalcium/calmodulin-dependent protein ...
Melanie I. Stefan, Nicolas Le Novère
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The role of calcium and CaMKII in sleep
Frontiers in Systems Neuroscience, 2022 Sleep is an evolutionarily conserved phenotype shared by most of the animals on the planet. Prolonged wakefulness will result in increased sleep need or sleep pressure. However, its mechanisms remain elusive. Recent findings indicate that Ca2+ signaling, known to control diverse physiological functions, also regulates sleep.
Yuyang Wang +4 more
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CASK regulates CaMKII autophosphorylation in neuronal growth, calcium signalling and learning [PDF]
, 2013 Calcium (Ca2+)/calmodulin (CaM)-dependent kinase II (CaMKII) activity plays a fundamental role in learning and memory. A key feature of CaMKII in memory formation is its ability to be regulated by autophosphorylation, which switches its activity on and ...
John M. Gillespie +5 more
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Experimental Antiarrhythmic Targets: CaMKII Inhibition - Ready for Clinical Evaluation? [PDF]
, 2014 In the recent years, Ca2+/calmodulin-dependent protein kinase II (CaMKII) was suggested to be associated with cardiac hypertrophy and heart failure but also with arrhythmias both in animal models as well as in the human heart. This article focuses on the
Maier, Lars S.
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CaMKII in Cardiometabolic Disease
Aging, 2014 The worldwide epidemic of obesity is closely linked to insulin resistance and type 2 diabetes (T2D), which have led to a critical need for new drug development. Insulin resistance and T2D contribute to the pathogenesis of many diseases including fatty liver disease, cardiovascular disease, kidney failure and retinal disease.
Lale, Ozcan, Ira, Tabas
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