Results 11 to 20 of about 33,635 (254)

Protection of α-CaMKII from Dephosphorylation by GluN2B Subunit of NMDA Receptor Is Abolished by Mutation of Glu96 or His282 of α-CaMKII. [PDF]

PLoS ONE, 2016
Interaction of CaMKII and the GluN2B subunit of NMDA receptor is essential for synaptic plasticity events such as LTP. Synaptic targeting of CaMKII and regulation of its biochemical functions result from this interaction.
Madhavan Mayadevi, Kesavan Lakshmi, Sudarsana Devi Suma Priya, Sebastian John, Ramakrishnapillai V Omkumar   +4 more
doaj   +3 more sources

The Delicate Bistability of CaMKII [PDF]

Biophysical Journal, 2013
Calcium/calmodulin-dependent protein kinase II (CaMKII) is a synaptic, autophosphorylating kinase that is essential for learning and memory. Previous models have suggested that CaMKII functions as a bistable switch that could be the molecular correlate of long-term memory, but experiments have failed to validate these predictions. These models involved
Michalski, P.J.
openaire   +4 more sources

Mechanisms of CaMKII Activation in the Heart [PDF]

Frontiers in Pharmacology, 2014
Calcium/calmodulin (Ca(2+)/CaM) dependent protein kinase II (CaMKII) has emerged as a key nodal protein in the regulation of cardiac physiology and pathology. Due to the particularly elegant relationship between the structure and function of the kinase, CaMKII is able to translate a diverse set of signaling events into downstream physiological effects.
Jeffrey R. Erickson, Jeffrey R Erickson
openaire   +4 more sources

CaMKII regulation of cardiac K channels [PDF]

Frontiers in Pharmacology, 2014
Cardiac K channels are critical determinants of cardiac excitability. In hypertrophied and failing myocardium, alterations in the expression and activity of voltage-gated K channels are frequently observed and contribute to the increased propensity for life-threatening arrhythmias. Thus, understanding the mechanisms of disturbed K channel regulation in
Mustroph, Julian, Maier, Lars S., Wagner, Stefan   +2 more
openaire   +6 more sources

Activation of Orexin System Stimulates CaMKII Expression [PDF]

Frontiers in Physiology, 2021
Hyperactivity of the orexin system within the paraventricular nucleus (PVN) has been shown to contribute to increased sympathetic nerve activity (SNA) and blood pressure (BP) in rodent animals. However, the underlying molecular mechanisms remain unclear.
Yuanyuan Fan, Yuanyuan Fan, Enshe Jiang, Enshe Jiang, Huanjia Gao, Huanjia Gao, Jeremy Bigalke, Bojun Chen, Chunxiu Yu, Chunxiu Yu, Qinghui Chen, Qinghui Chen, Zhiying Shan, Zhiying Shan   +13 more
doaj   +3 more sources

Metabolic Activation of CaMKII by Coenzyme A [PDF]

Molecular Cell, 2013
Active metabolism regulates oocyte cell death via calcium/calmodulin-dependent protein kinase II (CaMKII)-mediated phosphorylation of caspase-2, but the link between metabolic activity and CaMKII is poorly understood. Here we identify coenzyme A (CoA) as the key metabolic signal that inhibits Xenopus laevis oocyte apoptosis by directly activating ...
McCoy, Francis, Darbandi, Rashid, Lee, Hoi Chang, Bharatham, Kavitha, Moldoveanu, Tudor, Royappa, Grace, Dodd, Keela, Lin, Wenwei, Chen, Si-Ing, Tangallapally, Rajendra P., Kurokawa, Manabu, Lee, Richard E., Shelat, Anang, Chen, Taosheng, Green, Douglas R., Harris, Robert A., Lin, Sue-Hwa, Fissore, Rafael A., Colbran, Roger J., Nutt, Leta K.   +19 more
openaire   +6 more sources

Studying CaMKII: Tools and standards [PDF]

Cell Reports
The Ca2+/calmodulin (CaM)-dependent protein kinase II (CaMKII) is a ubiquitous mediator of cellular Ca2+ signals with both enzymatic and structural functions. Here, we briefly introduce the complex regulation of CaMKII and then provide a comprehensive overview of the expanding toolbox to study CaMKII.
Carolyn Nicole Brown, Karl Ulrich Bayer
openaire   +4 more sources

Architectural Dynamics of CaMKII-Actin Networks [PDF]

Biophysical Journal, 2019
Calcium-calmodulin-dependent kinase II (CaMKII) has an important role in dendritic spine remodeling upon synaptic stimulation. Using fluorescence video microscopy and image analysis, we investigated the architectural dynamics of rhodamine-phalloidin stabilized filamentous actin (F-actin) networks cross-linked by CaMKII. We used automated image analysis
Khan, Shahid, Downing, Kenneth H., Molloy, Justin E.   +2 more
openaire   +4 more sources

CaMKII and stress mix it up in mitochondria [PDF]

Frontiers in Pharmacology, 2014
CaMKII is a newly discovered resident of mitochondria in the heart. Mitochondrial CaMKII promotes poor outcomes after heart injury from a number of pathological conditions, including myocardial infarction, ischemia reperfusion and stress from ...
Olha M Koval, Mei-ling A Joiner
doaj   +3 more sources

Synaptic memory requires CaMKII [PDF]

eLife, 2021
Long-term potentiation (LTP) is arguably the most compelling cellular model for learning and memory. While the mechanisms underlying the induction of LTP (‘learning’) are well understood, the maintenance of LTP (‘memory’) has remained contentious over the last 20 years. Here, we find that Ca 2+
Wucheng Tao, Joel Lee, Xiumin Chen, Javier Díaz-Alonso, Jing Zhou, Samuel Pleasure, Roger A Nicoll   +6 more
openaire   +3 more sources