Results 11 to 20 of about 51,149 (268)
CaMKII and stress mix it up in mitochondria [PDF]
Frontiers in Pharmacology, 2014 CaMKII is a newly discovered resident of mitochondria in the heart. Mitochondrial CaMKII promotes poor outcomes after heart injury from a number of pathological conditions, including myocardial infarction, ischemia reperfusion and stress from ...
Olha M Koval, Mei-ling A Joiner
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Synaptic memory requires CaMKII [PDF]
eLife, 2021 Long-term potentiation (LTP) is arguably the most compelling cellular model for learning and memory. While the mechanisms underlying the induction of LTP (‘learning’) are well understood, the maintenance of LTP (‘memory’) has remained contentious over the last 20 years. Here, we find that Ca 2+
Wucheng Tao +6 more
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CaMKII in cerebral ischemia [PDF]
Acta Pharmacologica Sinica, 2011 Ischemic insults on neurons trigger excessive, pathological glutamate release that causes Ca²⁺ overload resulting in neuronal cell death (excitotoxicity). The Ca²⁺/calmodulin (CaM)-dependent protein kinase II (CaMKII) is a major mediator of physiological excitatory glutamate signals underlying neuronal plasticity and learning. Glutamate stimuli trigger
Steven J, Coultrap +4 more
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Circulation, 2011 Electrical storm (ES), a medical emergency, is the frequent occurrence of ventricular tachycardia or fibrillation, defined as 3 or more episodes in a 24-hour period. Although ES can occur in a variety of settings, including ischemia, heart failure, and channelopathies, general incidence and awareness of this condition have dramatically risen since the ...
Paari Dominic Swaminathan +1 more
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Influence of immobilization stress on the levels of CaMKII and phospho-CaMKII in the rat hippocampus [PDF]
The International Journal of Neuropsychopharmacology, 2004 The phosphorylation of calcium/calmodulin-dependent protein kinase (CaMK) II, induced by an increase in the intracellular Ca2+ concentration, is involved in the alteration of brain functions such as memory formation. In the present study, we examined the influence of various immobilization stress paradigms on the phosphorylation of CaMKII (phospho ...
Takami, Suenaga +4 more
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Quantitative Proteomics Analysis of CaMKII Phosphorylation and the CaMKII Interactome in the Mouse Forebrain [PDF]
ACS Chemical Neuroscience, 2015 Ca(2+)/calmodulin-dependent protein kinase IIα (CaMKIIα) autophosphorylation at Thr286 and Thr305/Thr306 regulates kinase activity and modulates subcellular targeting and is critical for normal synaptic plasticity and learning and memory. Here, a mass spectrometry-based approach was used to identify Ca(2+)-dependent and -independent in vitro ...
Baucum, Anthony J. +3 more
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Molecules for memory: modelling CaMKII [PDF]
BMC Systems Biology, 2007 Long-term modifications of synaptic strength, such aslong-term potentiation (LTP) or long-term depression(LTD) are thought to underlie some forms of learning andmemory. At the excitatory glutamate synapse, LTP isdependent on calcium influx through the N-methyl-D-aspartate (NMDA) receptor and subsequent activation ofcalcium/calmodulin-dependent protein ...
Melanie I. Stefan, Nicolas Le Novère
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The role of calcium and CaMKII in sleep
Frontiers in Systems Neuroscience, 2022 Sleep is an evolutionarily conserved phenotype shared by most of the animals on the planet. Prolonged wakefulness will result in increased sleep need or sleep pressure. However, its mechanisms remain elusive. Recent findings indicate that Ca2+ signaling, known to control diverse physiological functions, also regulates sleep.
Yuyang Wang +4 more
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Detailed state model of CaMKII activation and autophosphorylation [PDF]
, 2008 By combining biochemical experiments with computer modelling of biochemical reactions we elucidated some of the currently unresolved aspects of calcium-calmodulin-dependent protein kinase II (CaMKII) activation and autophosphorylation that might be ...
Greif, Gabriela J. +2 more
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Protection of α-CaMKII from Dephosphorylation by GluN2B Subunit of NMDA Receptor Is Abolished by Mutation of Glu96 or His282 of α-CaMKII. [PDF]
PLoS ONE, 2016 Interaction of CaMKII and the GluN2B subunit of NMDA receptor is essential for synaptic plasticity events such as LTP. Synaptic targeting of CaMKII and regulation of its biochemical functions result from this interaction.
Madhavan Mayadevi +4 more
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