Results 11 to 20 of about 49,123 (214)

Metformin: A Prospective Alternative for the Treatment of Chronic Pain

Frontiers in Pharmacology, 2020
Metformin (biguanide) is a drug widely used for the treatment of type 2 diabetes. This drug has been used for 60 years as a highly effective antihyperglycemic agent.
Guadalupe Del Carmen Baeza-Flores, Crystell Guadalupe Guzmán-Priego, Leonor Ivonne Parra-Flores, Janet Murbartián, Jorge Elías Torres-López, Jorge Elías Torres-López, Vinicio Granados-Soto   +6 more
doaj   +1 more source

Metabolic Maturation Exaggerates Abnormal Calcium Handling in a Lamp2 Knockout Human Pluripotent Stem Cell-Derived Cardiomyocyte Model of Danon Disease

Biomolecules, 2022
Danon disease (DD) is caused by mutations of the gene encoding lysosomal-associated membrane protein type 2 (LAMP2), which lead to impaired autophagy, glycogen accumulation, and cardiac hypertrophy.
Robert J. Barndt, Qing Liu, Ying Tang, Michael P. Haugh, Jeffery Cui, Stephen Y. Chan, Haodi Wu   +6 more
doaj   +1 more source

Porcine Circovirus Type 2 Activates CaMMKβ to Initiate Autophagy in PK-15 Cells by Increasing Cytosolic Calcium

Viruses, 2016
Porcine circovirus type 2 (PCV2) induces autophagy via the 5′ adenosine monophosphate-activated protein kinase (AMPK)/extracellular signal-regulated kinase (ERK)/tuberous sclerosis complex 2 (TSC2)/mammalian target of rapamycin (mTOR) pathway in pig ...
Yuanxing Gu, Baozhu Qi, Yingshan Zhou, Xiaowu Jiang, Xian Zhang, Xiaoliang Li, Weihuan Fang   +6 more
doaj   +1 more source

Ckip-1 3′-UTR Attenuates Simulated Microgravity-Induced Cardiac Atrophy

Frontiers in Cell and Developmental Biology, 2022
Microgravity prominently affected cardiovascular health, which was the gravity-dependent physical factor. Deep space exploration had been increasing in frequency, but heart function was susceptible to conspicuous damage and cardiac mass declined in ...
Yinglong Zhao, Yinglong Zhao, Guohui Zhong, Guohui Zhong, Ruikai Du, Dingsheng Zhao, Jianwei Li, Yuheng Li, Yuheng Li, Wenjuan Xing, Wenjuan Xing, Xiaoyan Jin, Wenjuan Zhang, Weijia Sun, Caizhi Liu, Zizhong Liu, Xinxin Yuan, Guanghan Kan, Xuan Han, Qi Li, Yan-Zhong Chang, Yingxian Li, Shukuan Ling   +22 more
doaj   +1 more source

Loss of myeloid differentiation protein 1 promotes atrial fibrillation in heart failure with preserved ejection fraction

ESC Heart Failure, 2020
Aims Myeloid differentiation protein 1 (MD1) is expressed in the mammalian heart and exerts an anti‐arrhythmic effect. Atrial fibrillation (AF) is closely related to heart failure with preserved ejection fraction (HFpEF).
Wei Shuai, Bin Kong, Hongjie Yang, Hui Fu, He Huang   +4 more
doaj   +1 more source

Cognitive enhancer ST101 improves schizophrenia-like behaviors in neonatal ventral hippocampus-lesioned rats in association with improved CaMKII/PKC pathway

Journal of Pharmacological Sciences, 2019
Atypical antipsychotics improve positive and negative symptoms but are not effective for treating cognitive impairments in patients with schizophrenia. We previously reported that cognitive impairments in neonatal ventral hippocampus (NVH)-lesioned rats ...
Yasushi Yabuki, Lei Wu, Kohji Fukunaga
doaj   +1 more source

New Phosphospecific Antibody Reveals Isoform-Specific Phosphorylation of CPEB3 Protein. [PDF]

PLoS ONE, 2016
Cytoplasmic Polyadenylation Element Binding proteins (CPEBs) are a family of polyadenylation factors interacting with 3'UTRs of mRNA and thereby regulating gene expression.
Lech Kaczmarczyk, Étienne Labrie-Dion, Kapil Sehgal, Marc Sylvester, Magdalena Skubal, Michele Josten, Christian Steinhäuser, Paul De Koninck, Martin Theis   +8 more
doaj   +1 more source

T-type calcium channel enhancer SAK3 produces anti-depressant-like effects by promoting adult hippocampal neurogenesis in olfactory bulbectomized mice

Journal of Pharmacological Sciences, 2018
T-type calcium channels are involved in the pathophysiology of epilepsy, pain, and sleep. Recently, we developed a novel spiroimidazopyridine compound, SAK3 (ethyl 8′-methyl-2′,4-dioxo-2-(piperidin-1-yl)-2′H-spiro[cyclopentane-1,3′-imidazo[1,2-a]pyridine]
Jing Xu, Yasushi Yabuki, Mengze Yu, Kohji Fukunaga   +3 more
doaj   +1 more source

Calcium Regulation on the Atrial Regional Difference of Collagen Production Activity in Atrial Fibrogenesis

Biomedicines, 2021
Background: Atrial fibrosis plays an important role in the genesis of heart failure and atrial fibrillation. The left atrium (LA) exhibits a higher level of fibrosis than the right atrium (RA) in heart failure and atrial arrhythmia.
Cheng-Chih Chung, Yung-Kuo Lin, Yao-Chang Chen, Yu-Hsun Kao, Yung-Hsin Yeh, Yi-Jen Chen   +5 more
doaj   +1 more source

Trans-cinnamaldehyde protects against phenylephrine-induced cardiomyocyte hypertrophy through the CaMKII/ERK pathway

BMC Complementary Medicine and Therapies, 2022
Background Trans-cinnamaldehyde (TCA) is one of the main pharmaceutical ingredients of Cinnamomum cassia Presl, which has been shown to have therapeutic effects on a variety of cardiovascular diseases.
Dongdong Qian, Jing Tian, Sining Wang, Xiaoli Shan, Pei Zhao, Huihua Chen, Ming Xu, Wei Guo, Chen Zhang, Rong Lu   +9 more
doaj   +1 more source