Results 11 to 20 of about 3,468,317 (412)

Correction: Abrogation of store-operated Ca2+ entry protects against crystal-induced ER stress in human proximal tubular cells

Cell Death Discovery, 2021
A Correction to this paper has been published: https://doi.org/10.1038/s41420-021-00445 ...
Farai C. Gombedza, Samuel Shin, Yianni L. Kanaras, Bidhan C. Bandyopadhyay   +3 more
doaj   +1 more source

Development and characterization of a monoclonal antibody blocking human TRPM4 channel

Scientific Reports, 2021
TRPM4 is a calcium-activated non-selective monovalent cation channel implicated in diseases such as stroke. Lack of potent and selective inhibitors remains a major challenge for studying TRPM4.
See Wee Low, Yahui Gao, Shunhui Wei, Bo Chen, Bernd Nilius, Ping Liao   +5 more
doaj   +1 more source

Excessive salt consumption causes systemic calcium mishandling and worsens microarchitecture and strength of long bones in rats

Scientific Reports, 2021
Excessive salt intake has been associated with the development of non-communicable diseases, including hypertension with several cardiovascular consequences.
Wacharaporn Tiyasatkulkovit, Sirion Aksornthong, Punyanuch Adulyaritthikul, Pornpailin Upanan, Kannikar Wongdee, Ratchaneevan Aeimlapa, Jarinthorn Teerapornpuntakit, Catleya Rojviriya, Nattapon Panupinthu, Narattaphol Charoenphandhu   +9 more
doaj   +1 more source

Ablation of TRPC3 disrupts Ca2+ signaling in salivary ductal cells and promotes sialolithiasis

Scientific Reports, 2023
Clinical studies and structural analyses of salivary stones strongly suggest a linkage between higher saliva calcium (Ca2+) and salivary stone formation, sialolithiasis; however, the process and the mechanism leading to Ca2+ overload during ...
Bok-Eum Choi, Samuel Shin, Sade Evans, Brij B. Singh, Bidhan C. Bandyopadhyay   +4 more
doaj   +1 more source

Extracellular Fe2+ and Fe3+ modulate osteocytic viability, expression of SOST, RANKL and FGF23, and fluid flow-induced YAP1 nuclear translocation

Scientific Reports, 2023
Iron overload negatively affects bone mass and strength. However, the impact of iron excess on osteocytes—important bone cells for mechanotransduction and remodeling—is poorly understood.
Wasutorn Chankamngoen, Saowalak Krungchanuchat, Jirawan Thongbunchoo, Naraporn Sirinonthanawech, Jarinthorn Teerapornpuntakit, Nattapon Panupinthu, Narattaphol Charoenphandhu   +6 more
doaj   +1 more source

Impaired olfactory neurogenesis affects the performance of olfactory-guided behavior in aged female opossums

Scientific Reports, 2021
Increasing evidence has indicated that adult neurogenesis contributes to brain plasticity, although function of new neurons is still under debate. In opossums, we performed an olfactory-guided behavior task and examined the association between olfactory ...
Beata Tepper, Paulina Koguc-Sobolewska, Katarzyna Jaslan, Krzysztof Turlejski, Katarzyna Bartkowska, Ruzanna Djavadian   +5 more
doaj   +1 more source

Store Operated Calcium Entry in Cell Migration and Cancer Metastasis

Cells, 2021
Ca2+ signaling is ubiquitous in eukaryotic cells and modulates many cellular events including cell migration. Directional cell migration requires the polarization of both signaling and structural elements.
Ayat S. Hammad, Khaled Machaca
doaj   +1 more source

Comparison of Anti-oncotic Effect of TRPM4 Blocking Antibody in Neuron, Astrocyte and Vascular Endothelial Cell Under Hypoxia

Frontiers in Cell and Developmental Biology, 2020
In stroke and other neurological diseases, Transient Receptor Potential Melastatin 4 (TRPM4) has been reported to cause oncotic cell death which is due to an excessive influx of sodium ions.
Shunhui Wei, See Wee Low, Charlene Priscilla Poore, Bo Chen, Yahui Gao, Bernd Nilius, Ping Liao, Ping Liao, Ping Liao   +8 more
doaj   +1 more source

Activation of cannabinoid receptors in breast cancer cells improves osteoblast viability in cancer-bone interaction model while reducing breast cancer cell survival and migration

Scientific Reports, 2022
The endocannabinoid system has been postulated to help restrict cancer progression and maintain osteoblastic function during bone metastasis. Herein, the effects of cannabinoid receptor (CB) type 1 and 2 activation on breast cancer cell and osteoblast ...
Tueanjai Khunluck, Kornkamon Lertsuwan, Chartinun Chutoe, Supagarn Sooksawanwit, Ingon Inson, Jarinthorn Teerapornpuntakit, Rutaiwan Tohtong, Narattaphol Charoenphandhu   +7 more
doaj   +1 more source

TRPM4 Blocking Antibody Protects Cerebral Vasculature in Delayed Stroke Reperfusion

Biomedicines, 2023
Reperfusion therapy for acute ischemic stroke aims to restore the blood flow of occluded blood vessels. However, successful recanalization is often associated with disruption of the blood-brain barrier, leading to reperfusion injury.
Bo Chen, Shunhui Wei, See Wee Low, Charlene Priscilla Poore, Andy Thiam-Huat Lee, Bernd Nilius, Ping Liao   +6 more
doaj   +1 more source