Results 11 to 20 of about 2,445,184 (215)

Binding epitope for recognition of human TRPM4 channel by monoclonal antibody M4M

Scientific Reports, 2022
Mouse monoclonal antibody M4M was recently designed to block human TRPM4 channel. The polypeptide for generating M4M is composed of peptide A1 between the transmembrane segment 5 (S5) and the pore, and a second peptide A2 between the pore and the ...
Shunhui Wei, Julian Behn, Charlene Priscilla Poore, See Wee Low, Bernd Nilius, Hao Fan, Ping Liao   +6 more
doaj   +1 more source

Impaired olfactory neurogenesis affects the performance of olfactory-guided behavior in aged female opossums

Scientific Reports, 2021
Increasing evidence has indicated that adult neurogenesis contributes to brain plasticity, although function of new neurons is still under debate. In opossums, we performed an olfactory-guided behavior task and examined the association between olfactory ...
Beata Tepper, Paulina Koguc-Sobolewska, Katarzyna Jaslan, Krzysztof Turlejski, Katarzyna Bartkowska, Ruzanna Djavadian   +5 more
doaj   +1 more source

The 2011 Report on Dietary Reference Intakes for Calcium and Vitamin D from the Institute of Medicine: What Clinicians Need to Know

Journal of Clinical Endocrinology and Metabolism, 2010
This article summarizes the new 2011 report on dietary requirements for calcium and vitamin D from the Institute of Medicine (IOM). An IOM Committee charged with determining the population needs for these nutrients in North America conducted a ...
A. Ross, J. Manson, S. Abrams, J. F. Aloia, J. F. Aloia, P. Brannon, S. Clinton, R. Durazo-Arvizu, J. Gallagher, R. Gallo, Glenville Jones, C. Kovacs, S. Mayne, C. Rosen, S. Shapses   +14 more
semanticscholar   +1 more source

HSPB7 oppositely regulates human mesenchymal stromal cell-derived osteogenesis and adipogenesis

Stem Cell Research & Therapy, 2023
Background Recent evidence suggests that accumulation of marrow adipose tissue induced by aberrant lineage allocation of bone marrow-derived mesenchymal stromal cells (BMSCs) contributes to the pathophysiologic processes of osteoporosis.
Shuang Zhang, Jeroen van de Peppel, Marijke Koedam, Johannes P. T. M. van Leeuwen, Bram C. J. van der Eerden   +4 more
doaj   +1 more source

Hypercalciuria switches Ca2+ signaling in proximal tubular cells, induces oxidative damage to promote calcium nephrolithiasis

Genes and Diseases, 2022
Proximal tubule (PT) transports most of the renal Ca2+, which was usually described as paracellular (passive). We found a regulated Ca2+ entry pathway in PT cells via the apical transient receptor potential canonical 3 (TRPC3) channel, which initiates ...
Samuel Shin, Cliff-Lawrence Ibeh, Eugenia Awuah Boadi, Bok-Eum Choi, Sanjit K. Roy, Bidhan C. Bandyopadhyay   +5 more
doaj   +1 more source

Activation of cannabinoid receptors in breast cancer cells improves osteoblast viability in cancer-bone interaction model while reducing breast cancer cell survival and migration

Scientific Reports, 2022
The endocannabinoid system has been postulated to help restrict cancer progression and maintain osteoblastic function during bone metastasis. Herein, the effects of cannabinoid receptor (CB) type 1 and 2 activation on breast cancer cell and osteoblast ...
Tueanjai Khunluck, Kornkamon Lertsuwan, Chartinun Chutoe, Supagarn Sooksawanwit, Ingon Inson, Jarinthorn Teerapornpuntakit, Rutaiwan Tohtong, Narattaphol Charoenphandhu   +7 more
doaj   +1 more source

Calcium Absorption from Food Products: Food Matrix Effects

Nutrients, 2021
This article reviews physicochemical aspects of calcium absorption from foods. Notable differences are observed between different food products in relation to calcium absorption, which range from 50% of calcium in the foods.
Blerina Shkembi, T. Huppertz
semanticscholar   +1 more source

Secretion of the Phosphorylated Form of S100A9 from Neutrophils Is Essential for the Proinflammatory Functions of Extracellular S100A8/A9

Frontiers in Immunology, 2018
S100A8 and S100A9 are members of the S100 family of cytoplasmic EF-hand Ca2+-binding proteins and are abundantly expressed in the cytosol of neutrophils. In addition to their intracellular roles, S100A8/A9 can be secreted in the extracellular environment
Véronique Schenten, Sébastien Plançon, Nicolas Jung, Justine Hann, Jean-Luc Bueb, Sabrina Bréchard, Eric J. Tschirhart, Fabrice Tolle   +7 more
doaj   +1 more source

Melamine promotes calcium crystal formation in three-dimensional microfluidic device

Scientific Reports, 2019
Melamine, which induces proximal tubular (PT) cell damage has a greater nephrotoxic effect when combined with cyanuric and uric acids; however, it is unknown whether such effect can stimulate calcium phosphate (CaP)/calcium oxalate (CaOx) stone formation.
Farai Gombedza, Sade Evans, Samuel Shin, Eugenia Awuah Boadi, Qian Zhang, Zhihong Nie, Bidhan C. Bandyopadhyay   +6 more
doaj   +1 more source

Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators

Nature Methods, 2009
Genetically encoded calcium indicators (GECIs) can be used to image activity in defined neuronal populations. However, current GECIs produce inferior signals compared to synthetic indicators and recording electrodes, precluding detection of low firing ...
L. Tian, S. Hires, Tianyi Mao, D. Huber, M. Chiappe, Sreekanth H. Chalasani, L. Petreanu, Jasper Akerboom, S. McKinney, E. Schreiter, Cori Bargmann, V. Jayaraman, K. Svoboda, L. Looger   +13 more
semanticscholar   +1 more source