Results 11 to 20 of about 3,058,950 (364)
Binding epitope for recognition of human TRPM4 channel by monoclonal antibody M4M
Scientific Reports, 2022 Mouse monoclonal antibody M4M was recently designed to block human TRPM4 channel. The polypeptide for generating M4M is composed of peptide A1 between the transmembrane segment 5 (S5) and the pore, and a second peptide A2 between the pore and the ...
Shunhui Wei +6 more
doaj +1 more source
Store Operated Calcium Entry in Cell Migration and Cancer Metastasis
Cells, 2021 Ca2+ signaling is ubiquitous in eukaryotic cells and modulates many cellular events including cell migration. Directional cell migration requires the polarization of both signaling and structural elements.
Ayat S. Hammad, Khaled Machaca
doaj +1 more source
Kidney International, 2000 Calcium is an important intracellular signaling molecule, and altered calcium channel function can cause widespread cellular changes. Genetic mutations in calcium channels that cause what appear to be trivial alterations of calcium currents in vitro can result in serious diseases in muscles and the nervous system.
Lorenzon, Nancy M., Beam, Kurt G.
openaire +2 more sources
Scientific Reports, 2022 The endocannabinoid system has been postulated to help restrict cancer progression and maintain osteoblastic function during bone metastasis. Herein, the effects of cannabinoid receptor (CB) type 1 and 2 activation on breast cancer cell and osteoblast ...
Tueanjai Khunluck +7 more
doaj +1 more source
Water calcium concentration modifies whole-body calcium uptake in sea bream larvae during short-term adaptation to altered salinities [PDF]
, 2014 Whole-body calcium uptake was studied in gilthead sea bream larvae (9–83·mg) in response to changing environmental salinity and [Ca2+]. Calcium uptake increased with increased fish size and salinity.
Canario, Adelino V. M. +5 more
core +1 more source
Genes and Diseases, 2022 Proximal tubule (PT) transports most of the renal Ca2+, which was usually described as paracellular (passive). We found a regulated Ca2+ entry pathway in PT cells via the apical transient receptor potential canonical 3 (TRPC3) channel, which initiates ...
Samuel Shin +5 more
doaj +1 more source
Junctate is a key element in calcium entry induced by activation of InsP3 receptors and/or calcium store depletion [PDF]
, 2004 In many cell types agonist-receptor activation leads to a rapid and transient release of Ca(2+) from intracellular stores via activation of inositol 1,4,5 trisphosphate (InsP(3)) receptors (InsP(3)Rs).
Treves, Susan +12 more
core +3 more sources
HSPB7 oppositely regulates human mesenchymal stromal cell-derived osteogenesis and adipogenesis
Stem Cell Research & Therapy, 2023 Background Recent evidence suggests that accumulation of marrow adipose tissue induced by aberrant lineage allocation of bone marrow-derived mesenchymal stromal cells (BMSCs) contributes to the pathophysiologic processes of osteoporosis.
Shuang Zhang +4 more
doaj +1 more source
Frontiers in Immunology, 2018 S100A8 and S100A9 are members of the S100 family of cytoplasmic EF-hand Ca2+-binding proteins and are abundantly expressed in the cytosol of neutrophils. In addition to their intracellular roles, S100A8/A9 can be secreted in the extracellular environment
Véronique Schenten +7 more
doaj +1 more source
Calcium Carbonate Suppresses Haem Toxicity Markers without Calcium Phosphate Side Effect on Colon Carcinogenesis [PDF]
, 2010 Red meat intake is associated with increased risk of colorectal cancer. We have previously shown that haemin, haemoglobin and red meat promote carcinogen-induced preneoplastic lesions, aberrant crypt foci, in the colon of rats.
Belbraouet +14 more
core +5 more sources