Results 191 to 200 of about 149,086 (250)

Adrenal insufficiency influences the pattern of thyrotoxicosis toward triiodothyronine predominance. [PDF]

JCEM Case Rep
Maruoka A, Nishimura K, Mukai C, Takahashi K, Irie J, Toyoda N.   +5 more
europepmc   +1 more source

Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing

Advanced Science, EarlyView.
Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan, Xuran Li, Han Wang, Lin Sun, Yao Wang, Jiangdong Wu, Junqi Cui, Yiqi Yang, Kai Yuan, Linyang Chu, Liao Wang, Hanjun Li, Mengning Yan, Zhifeng Yu   +13 more
wiley   +1 more source

Strategies to Enhance Yield of Wet-Synthesized Hydroxyapatite Nanocrystals and Consequences for Drug-Release Kinetics. [PDF]

Materials (Basel)
Krukowski S, Byra N, Adamczyk A, Biały J.   +3 more
europepmc   +1 more source

T2T Genome Assembly and Multi‐Omics Data Reveal Terrestrial Adaptation and Mucus Biosynthesis in Tropical Leatherleaf Slug (Laevicaulis alte)

Advanced Science, EarlyView.
A gap‐free genome assembly and multi‐omics comparison of the terrestrial slug Laevichaulis alte with an aquatic relative reveal that expansion of the VEGF family orchestrates mucus production, lipid metabolism, and immune defense—highlighting key molecular innovations for conquering life on land.
Gang Wang, Shaofang He, Zhongkai Wang, Aobo Pang, Xiaoli Sun, Rongchen Liu, Fang Wang, Sisi Chen, Zhijuan Bian, Dongcheng Wei, Liuhan Wu, Siyao Zhao, Qiuting Ji, Yiqi Sun, Niying Sun, Yushinta Fujaya, Boping Tang, Kianann Tan, Daizhen Zhang, Lianfu Chen   +19 more
wiley   +1 more source

Astrocytic regulation in hippocampal CA2 mediates the impact of sleep deprivation on spatial working memory. [PDF]

Front Syst Neurosci
He J, Ye Y, Fang J, Wang J, Cheung H.
europepmc   +1 more source

In Situ Calcium Carbonate Mineralization of Mycelium Composites: Processing Challenges and Physical-Mechanical Property Implications. [PDF]

ACS Omega
Akromah S, Chandarana N, Eichhorn SJ.
europepmc   +1 more source

Alternative Base Solutions for del Nido Cardioplegia: Composition, Rationale, and Clinical Evidence. [PDF]

Interdiscip Cardiovasc Thorac Surg
Kantathut N.
europepmc   +1 more source

Identification of two odorant receptors tuned to alarm pheromone compounds in the honey bee Apis mellifera. [PDF]

Commun Biol
Andreu B, Mariette J, Delarue A, Larcher V, Hueber A, Touboul D, Montagné N, Chertemps T, Jacquin-Joly E, Carcaud J, Sandoz JC.   +10 more
europepmc   +1 more source

Bioactive Profiling of <i>Achillea millefolium</i> L. Growing in Kashmir: A Study on Its Phytochemical and LC-MS Analysis, Antioxidant Properties, and Antimicrobial and Molecular Docking Analysis. [PDF]

Can J Infect Dis Med Microbiol
Paul ZA, Mir RH, Malla AT, Adnan M, Patel M, Kumar R, Wani SUD, Zargar MI, Masoodi MH.   +8 more
europepmc   +1 more source