Results 131 to 140 of about 3,675,768 (408)

Calcium current homeostasis and synaptic deficits in hippocampal neurons from Kelch-like 1 knockout mice

open access: yesFrontiers in Cellular Neuroscience, 2015
Kelch-like 1 (KLHL1) is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (α1H T-type) calcium channels; KLHL1 knockdown experiments (KD) cause down-regulation of both channel types and altered synaptic properties
Paula Patricia Perissinotti   +7 more
doaj   +1 more source

Calcium channel blockers revisited [PDF]

open access: yes, 2002
published_or_final_versio
Cheung, BMY, Kumana, CR
core  

Diffusion‐based size determination of solute particles: a method adapted for postsynaptic proteins

open access: yesFEBS Open Bio, EarlyView.
We present a diffusion‐based approach for measuring the size of macromolecules and their complexes, and demonstrate its use on postsynaptic proteins. The method requires fluorescein‐labelled protein samples, a microfluidic device that maintains laminar flow for said samples, a microscope recording the emitted fluorescent signals, and an analytic ...
András László Szabó   +7 more
wiley   +1 more source

Calcium channel roundup [PDF]

open access: yesJournal of Cell Biology, 2009
Thanks to a protein that helps fruit flies remain airborne, researchers have deciphered a key step in synapse maturation. [Fouquet et al.][1] show that the protein forms part of a synaptic structure that clusters the calcium channels necessary for neurotransmitter release.
openaire   +2 more sources

Report on the 2nd MObility for Vesicle research in Europe (MOVE) symposium—2024

open access: yesFEBS Open Bio, EarlyView.
The 2nd MObility for Vesicle research in Europe (MOVE) Symposium in Belgrade brought over 280 attendees from 28 countries to advance extracellular vesicle (EV) research. Featuring keynotes, presentations, and industry sessions, it covered EV biogenesis, biomarkers, therapies, and manufacturing.
Dorival Mendes Rodrigues‐Junior   +5 more
wiley   +1 more source

Molecular cloning, functional properties, and distribution of rat brain alpha 7: a nicotinic cation channel highly permeable to calcium

open access: yesJournal of Neuroscience, 1993
A full-length clone coding for the rat alpha 7 nicotinic receptor subunit was isolated from an adult brain cDNA library and expressed in Xenopus oocytes. A significant proportion of the current through alpha 7-channels is carried by Ca2+.
Philippe Sbgu&a   +4 more
semanticscholar   +1 more source

Calcium Channel Blockers and Hypertension

open access: yesJournal of Cardiovascular Pharmacology and Therapeutics, 2014
Effective treatment of high blood pressure (BP) represents a key strategy for reducing the burden of hypertension-related cardiovascular and renal diseases. In spite of these well-established concepts, hypertension remains poorly controlled worldwide.
TOCCI, GIULIANO   +6 more
openaire   +4 more sources

Electrical pulse stimulation reflecting the episodic nature of real‐life exercise modulates metabolic and secretory profile of primary human myotubes

open access: yesFEBS Open Bio, EarlyView.
Here, we introduced an intermittent electrical stimulation protocol mimicking the episodic nature of real‐life exercise in vitro by alternating low‐ and high‐frequency stimulation. In comparison with widely used continuous stimulation, it enhanced the rate of glucose and fatty acid oxidation, but not the myokine release.
Klára Gabrišová   +11 more
wiley   +1 more source

FGF23 promotes renal calcium reabsorption through the TRPV5 channel

open access: yesEMBO Journal, 2014
αKlotho is thought to activate the epithelial calcium channel Transient Receptor Potential Vanilloid‐5 (TRPV5) in distal renal tubules through its putative glucuronidase/sialidase activity, thereby preventing renal calcium loss.
O. Andrukhova   +10 more
semanticscholar   +1 more source

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