Results 151 to 160 of about 3,675,768 (408)
Biological Research, 2004 The InsP3R Ca2+-release channel has biphasic dependence on cytoplasmic free Ca2+ concentration ([Ca2+]i). InsP3 activates gating primarily by reducing high [Ca2+]i inhibition.
J. Kevin Foskett, D.-O. Daniel Mak
doaj
Enhancement of vasoconstrictor and attenuation of vasodilator effects of 5-hydroxytryptamine by the calcium channel blockers nimodipine and nifedipine in the pig [PDF]
, 1987 Dirk J. Duncker +4 more
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FEBS Open Bio, EarlyView.Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani +7 more
wiley +1 more source
Inhibition of calcium channels by harmaline and other harmala alkaloids in vascular and intestinal smooth muscles [PDF]
, 1987 Hideaki Karaki, T. Kishimoto, H Ozaki
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Age‐Related Changes in Myeloid Cells and Their Impact on Subcutaneous Melanoma Growth in Mice
Aging and Cancer, EarlyView.Our findings reveal that age‐related changes in subcutaneous melanoma growth and immunotherapy response are context‐dependent. In models where tumor growth and treatment resistance increase with age, this effect is partly driven by enhanced immunosuppression from myeloperoxidase‐active Gr‐1⁺ myeloid cells.
Kaitlyn M. Landreth +7 more
wiley +1 more source
Identification of a novel loss-of-function calcium channel gene mutation in short QT syndrome (SQTS6) [PDF]
, 2017 Aims Short QT syndrome (SQTS) is a genetically determined ion-channel disorder, which may cause malignant tachyarrhythmias and sudden cardiac death. Thus far, mutations in five different genes encoding potassium and calcium channel subunits have been ...
Abriel, Hugues +14 more
core
Cystic Ovarian Teratoma: Clinical and Radiographic Insights Into Chronic Pelvic Pain
Aging and Cancer, EarlyView.An incidental benign mature cystic ovarian teratoma on imaging and discuss common imaging modalities. ABSTRACT In this case report, we present the clinical course of an 88‐year‐old woman with chronic pelvic pain attributed to an incidental benign mature cystic ovarian teratoma on imaging and discuss common imaging modalities and discussions with ...
Hashim U. Ali +5 more
wiley +1 more source
The BK Channel Limits the Pro-Inflammatory Activity of Macrophages
CellsMacrophages play a crucial role in the innate immune response, serving as key effector cells in the defense against pathogens. Although the role of the large-conductance voltage and calcium-activated potassium channel, also known as the KCa1.1 or BK ...
Yihe Chen +6 more
doaj +1 more source
Central Dysmyelination in SSADH‐Deficient Humans and Mice
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives Succinic semialdehyde dehydrogenase deficiency (SSADHD) is an inherited metabolic disorder characterized by an accumulation of γ‐aminobutyric (GABA). In addition to its synaptic role as an inhibitory neurotransmitter, GABA also plays an important role in myelination.
Itay Tokatly Latzer +11 more
wiley +1 more source