Results 281 to 290 of about 295,986 (313)

Calcium channel activation stabilizes a neuronal calcium channel mRNA

Nature Neuroscience, 1999
We have identified a calcium-dependent pathway in neurons that regulates expression levels of the alpha1B subunit and N channel current. When neurons are depolarized and voltage-gated calcium channels activated, the half-life of cellular N channel alpha1B mRNA is prolonged.
Maureen W. McEnery, Seema Gupta, Stephanie Schorge, Zhixin Lin, Zhixin Lin, Diane Lipscombe   +5 more
openaire   +3 more sources

Inactivation of calcium channels

Comparative Biochemistry and Physiology Part A: Physiology, 1989
Rapid progress in our understanding of the properties and functions of voltage-gated calcium channels had produced the need for an update to our previous review of calcium inactivation. The major elements of change included in this review are: 1.
openaire   +4 more sources

Calcium Channels and Calcium-Regulated Channels in Human Red Blood Cells

2019
Free Calcium (Ca2+) is an important and universal signalling entity in all cells, red blood cells included. Although mature mammalian red blood cells are believed to not contain organelles as Ca2+ stores such as the endoplasmic reticulum or mitochondria, a 20,000-fold gradient based on a intracellular Ca2+ concentration of approximately 60 nM vs.
Kaestner, Lars, Bogdanova, Anna, Egee, Stephane   +2 more
openaire   +4 more sources

L-type calcium channels and calcium channel ligands

1992
Abstract L-type calcium channels possess high affinity drug binding domains for different chemical classes of calcium channel active drugs. Reversible binding experiments using radiolabeled and fluorescently labeled calcium antagonists revealed tight allosteric coupling between several distinct drug binding domains and divalent cation binding sites ...
Hartmut Glossmann, Jörg Striessnig
openaire   +2 more sources

Calcium channel diversity: multiple roles of calcium channel subunits

Current Opinion in Neurobiology, 2009
Until recently we held the simple view that voltage-gated calcium channels consisted of an alpha1 subunit, usually associated with auxiliary beta subunits and alpha(2)delta subunits and that skeletal muscle calcium channels were also associated with a gamma subunit.
openaire   +3 more sources

[42] Assay for calcium channels

1985
Publisher Summary This chapter focuses on biochemical assays for Ca 2+ -selective channels in electrically excitable membranes, which are blocked in electrophysiological and pharmacological experiments by verapamil, 1,4-dihydro-pyridines, diltiazem (and various other drugs), as well as inorganic di- or trivalent cations.
Hartmut Glossmann, D. R. Ferry
openaire   +3 more sources

Calcium Channel

Annual Review of Neuroscience, 1981
S, Hagiwara, L, Byerly
openaire   +2 more sources

Advances in TRP channel drug discovery: from target validation to clinical studies

Nature Reviews Drug Discovery, 2022
Ari-pekka Koivisto, Sandra Duffy, Arpad Szallasi   +2 more
exaly  

Neuronal Calcium Channels

Journal of Neurosurgical Anesthesiology, 1989
Dennis W. Choi, Rona G. Giffard
openaire   +3 more sources

Calcium Channel Blockers

Clinical Obstetrics and Gynecology, 1995
Donald C. Dyson, Deborah A. Ray
openaire   +3 more sources