Regulation of Presynaptic Calcium Channels by Synaptic Proteins
Journal of Pharmacological Sciences, 2003 Calcium entry into nerve termini via voltage gated calcium channels is an essential step in neurotransmission. Consequently, second messenger regulation of calcium channel activity modulates synaptic activity.
Gerald W. Zamponi
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Tissue-specific expression of calcium channels [PDF]
, 1993 The high-voltage-activated calcium channel is a multimeric protein complex containing 1, 2/δ, β, and γ subunits. The 1 subunit is the ion conduction channel and contains the binding sites for calcium channel blockers and toxins.
Flockerzi, Veit +3 more
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P/Q-type calcium-channel blockade in the periaqueductal gray facilitates trigeminal nociception: a functional genetic link for migraine? [PDF]
, 2002 The discovery of mis-sense mutations in the alpha1A subunit of the P/Q-type calcium channel in patients with familial hemiplegic migraine indicates the potential involvement of dysfunctional ion channels in migraine.
Goadsby, PJ +11 more
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Calcium Channel Antagonist Toxicity
MedEdPORTAL, 2014 Introduction This simulation case was designed to teach emergency medicine physicians, pediatricians, and other health care providers about the clinical presentation, stabilization, and medical management of the patient with suspected or proven toxic ...
Elaine Fielder +2 more
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Disparate effects of calcium channel blockers on pressure dependence of renin secretion and flow in the isolated perfused rat kidney [PDF]
, 1992 Using the model of isolated perfused rat kidneys this study was performed to investigate whether or not voltage-operated calcium channels are essentially involved in the pressure control of renin secretion from the kidneys. At a perfusion pressure of 100
Scholz, Holger, Kurtz, Armin
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Electrophysiological characterization of activation state-dependent Cav2 channel antagonist TROX-1 in spinal nerve injured rats. [PDF]
, 2015 Prialt, a synthetic version of Cav2.2 antagonist ω-conotoxin MVIIA derived from Conus magus, is the first clinically approved voltage-gated calcium channel blocker for refractory chronic pain.
Schiene, K. +17 more
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The ER calcium channel Csg2 integrates sphingolipid metabolism with autophagy
Nature Communications, 2023 Sphingolipids are ubiquitous components of membranes and function as bioactive lipid signaling molecules. Here, through genetic screening and lipidomics analyses, we find that the endoplasmic reticulum (ER) calcium channel Csg2 integrates sphingolipid ...
Shiyan Liu +10 more
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Calcium channels in lymphocytes [PDF]
Immunology, 2001 On B and T lymphocytes, ligation of the antigen receptor (AgR) induces a biphasic Ca2+ response. In the initial phase there is a large elevation in the intracellular Ca2+ concentration as a consequence of Ca2+ release from intracellular stores. This is followed by a lower, but prolonged elevation that is dependent on extracellular Ca2+.1,2 This simple ...
G, Grafton, L, Thwaite
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Developmental Regulation of Small-Conductance Ca²⁺-Activated K⁺ Channel Expression and Function in Rat Purkinje Neurons [PDF]
, 2002 Calcium transients play an important role in the early and later phases of differentiation and maturation of single neurons and neuronal networks. Small-conductance calcium-activated potassium channels of the SK type modulate membrane excitability and ...
Stocker, M +16 more
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Calcium channel blockers- Induced iatrogenic gingival hyperplasia: Case series
Journal of Pharmacy and Bioallied Sciences, 2023 Hypertension rightfully termed as “Silent killer” is associated with increase in morbidity and mortality when left untreated. Calcium channel blockers are the most commonly prescribed first-line anti-hypertensive drugs in India.
G Agnes Golda Priyadarshini +4 more
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