Results 101 to 110 of about 3,292,953 (284)

TRPM8 and Nav1.8 sodium channels are required for transthyretin-induced calcium influx in growth cones of small-diameter TrkA-positive sensory neurons

open access: yesMolecular Neurodegeneration, 2011
Background Familial amyloidotic polyneuropathy (FAP) is a peripheral neuropathy caused by the extracellular accumulation and deposition of insoluble transthyretin (TTR) aggregates. However the molecular mechanism that underlies TTR toxicity in peripheral
Vincent Adele J   +7 more
doaj   +1 more source

Calcium Channel Blockers

open access: yesMedical Clinics of North America, 1988
The calcium channel blockers initially were approved for the treatment of classical and variant angina pectoris. Recent studies indicate that these agents also are useful in such diverse conditions as pulmonary and systemic hypertension, hypertrophic cardiomyopathy, arrhythmias, asthma, Raynaud's syndrome, esophageal spasm, myometrial hyperactivity ...
openaire   +3 more sources

Study of Selectivity and Permeation In Voltage-Gated Ion Channels [PDF]

open access: yesarXiv, 2012
Ion channels are membrane proteins responsible for an enormous range of biological functions. Ion selectivity and permeation are based on simple laws of physics and chemistry. Ion channels are therefore ideal candidates for physical investigation. A reduced model generates the selectivity of voltage-gated L-type calcium channel under a wide range of ...
arxiv  

Signaling complexes of voltage-gated calcium channels

open access: yesChannels, 2011
Voltage gated calcium channels are key mediators of depolarization induced calcium entry into electrically excitable cells. There is increasing evidence that voltage gated calcium channels, like many other types of ionic channels, do not operate in ...
R. W. Turner   +2 more
semanticscholar   +1 more source

Neuroprotective effects of blockers for T-type calcium channels

open access: yesMolecular Neurodegeneration, 2009
Cognitive and functional decline with age is correlated with deregulation of intracellular calcium, which can lead to neuronal death in the brain.
Lei Debin   +4 more
doaj   +1 more source

Regulatory Mechanisms and Pathophysiological Significance of IP3 Receptors and Ryanodine Receptors in Drug Dependence

open access: yesJournal of Pharmacological Sciences, 2013
Calcium is a ubiquitous intracellular signaling molecule required for initiating and regulating neuronal functions. Ca2+ release from intracellular stores in the endoplasmic reticulum into intracellular spaces via intracellular Ca2+–releasing channels ...
Koji Mizuno   +2 more
doaj  

Ion Channels, Natural Nanovalves [PDF]

open access: yesarXiv, 2012
Ion channels are proteins with holes down their middle that control the flow of ions and electric current across otherwise impermeable biological membranes. The flow of sodium, potassium, calcium (divalent), and chloride ions have been central issues in biology for more than a century.
arxiv  

T-type calcium channels contribute to colonic hypersensitivity in a rat model of irritable bowel syndrome

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2011
The symptoms of irritable bowel syndrome (IBS) include significant abdominal pain and bloating. Current treatments are empirical and often poorly efficacious, and there is a need for the development of new and efficient analgesics aimed at IBS patients ...
Fabrice Marger   +12 more
semanticscholar   +1 more source

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