Results 91 to 100 of about 3,686,002 (351)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Mitochondrial DNA mutations affect calcium handling in differentiated neurons.
, 2010 Contains fulltext : 88975.pdf (Publisher’s version ) (Closed access)Mutations in the mitochondrial genome are associated with a wide range of neurological symptoms, but many aspects of the basic neuronal pathology are not understood ...
Enriquez, J.A. +26 more
core +1 more source
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2013 Missense mutations in CACNA1A, the gene that encodes the pore-forming α1 subunit of human voltage-gated Ca(V)2.1 (P/Q-type) calcium channels, cause a rare form of migraine with aura (familial hemiplegic migraine type 1: FHM1). Migraine is a common disabling brain disorder whose key manifestations are recurrent attacks of unilateral headache that may be
openaire +5 more sources
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Calcium activates SK channels in the intact human lens
, 2003 Purpose: Apamin-sensitive, calcium-activated SK potassium channels have been implicated in schizophrenia and myotonic dystrophy (MD), and both conditions carry an increased risk of cataract.
Rhodes, Jeremy D. +2 more
core +1 more source
Self-organized enhancement of conductivity in biological ion channels [PDF]
, 2013 We discuss an example of self-organization in a biological system. It arises from long-range ion–ion interactions, and it leads us to propose a new kind of enhanced conduction in ion channels.
Kaufman, Igor +9 more
core +1 more source
Calcium Channel Blockers and Hypertension
Journal of Cardiovascular Pharmacology and Therapeutics, 2014 Effective treatment of high blood pressure (BP) represents a key strategy for reducing the burden of hypertension-related cardiovascular and renal diseases. In spite of these well-established concepts, hypertension remains poorly controlled worldwide. In order to improve BP control in patients with hypertension, several interventions have been proposed,
TOCCI, GIULIANO +6 more
openaire +3 more sources
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Patch clamp studies of human sperm under physiological ionic conditions reveal three functionally and pharmacologically distinct cation channels [PDF]
, 2014 Whilst fertilizing capacity depends upon a K+ conductance G? that allows the spermatozoon membrane potential Vm to be held at a negative value, the characteristics of this conductance in human sperm are virtually unknown.
Barratt, C.L.R.; id_orcid +8 more
core +1 more source