Results 91 to 100 of about 1,575,123 (299)
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2000 We propose a model of calcium channels that can explain most of their observed properties, including the anomalous mole fraction effect and mutation of the glutamate residues. The structure grossly resembles that of the KcsA potassium channel except for the presence of an extracellular vestibule and a shorter selectivity filter containing four ...
Corry, Ben +3 more
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Calcium accumulation in visual interneurons of the fly: stimulus dependence and relationship to membrane potential [PDF]
, 1995 Egelhaaf M, Borst A. Calcium accumulation in visual interneurons of the fly: stimulus dependence and relationship to membrane potential. Journal of neurophysiology. 1995;73(6):2540-2552.1.
Egelhaaf, M. +5 more
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FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Role of calcium-activated potassium channels in the heart
Cardiology Plus, 2017 Ability of intracellular calcium to open K+-selective channels in an excitable membrane and to hasten repolarization of an action potential or inhibit firing is a fundamental principle of biology first recognized in the mid-1970s. There are several types
William T Clusin
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FEBS Open Bio, EarlyView.Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata +13 more
wiley +1 more source
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2013 Missense mutations in CACNA1A, the gene that encodes the pore-forming α1 subunit of human voltage-gated Ca(V)2.1 (P/Q-type) calcium channels, cause a rare form of migraine with aura (familial hemiplegic migraine type 1: FHM1). Migraine is a common disabling brain disorder whose key manifestations are recurrent attacks of unilateral headache that may be
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Calcium Channel Blockers and Hypertension
Journal of Cardiovascular Pharmacology and Therapeutics, 2014 Effective treatment of high blood pressure (BP) represents a key strategy for reducing the burden of hypertension-related cardiovascular and renal diseases. In spite of these well-established concepts, hypertension remains poorly controlled worldwide. In order to improve BP control in patients with hypertension, several interventions have been proposed,
TOCCI, GIULIANO +6 more
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A multiscale hybrid model for pro-angiogenic calcium signals in a vascular endothelial cell [PDF]
, 2011 Cytosolic calcium machinery is one of the principal signaling mechanisms by which endothelial cells (ECs) respond to external stimuli during several biological processes, including vascular progression in both physiological and pathological conditions ...
Marco Scianna, Scianna, Marco
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SH Oxidation Stimulates Calcium Release Channels (Ryanodine Receptors) From Excitable Cells
Biological Research, 2000 The effects of redox reagents on the activity of the intracellular calcium release channels (ryanodine receptors) of skeletal and cardiac muscle, or brain cortex neurons, was examined. In lipid bilayer experiments, oxidizing agents (2,2'-dithiodipyridine
CECILIA HIDALGO +4 more
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