Results 81 to 90 of about 475,886 (304)

Developmental Regulation of Small-Conductance Ca²⁺-Activated K⁺ Channel Expression and Function in Rat Purkinje Neurons [PDF]

, 2002
Calcium transients play an important role in the early and later phases of differentiation and maturation of single neurons and neuronal networks. Small-conductance calcium-activated potassium channels of the SK type modulate membrane excitability and ...
Boccaccio, A, Cingolani, LA, Gymnopoulos, M, Pedarzani, P, Stocker, M   +4 more
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Levels of Ca\u3csub\u3ev\u3c/sub\u3e1.2 L-Type Ca\u3csup\u3e2+\u3c/sup\u3e Channels Peak in the First Two Weeks in Rat Hippocampus Whereas Ca\u3csub\u3ev\u3c/sub\u3e1.3 Channels Steadily Increase through Development [PDF]

, 2012
Influx of calcium through voltage-dependent channels regulates processes throughout the nervous system. Specifically, influx through L-type channels plays a variety of roles in early neuronal development and is commonly modulated by G-protein-coupled ...
Ingraham, Nicholas E., Kramer, Audra A., Mynlieff, Michelle, Sharpe, Emily J.   +3 more
core   +1 more source

A phenomenological cluster-based model of Ca2+ waves and oscillations for Inositol 1,4,5-trisphosphate receptor (IP3R) channels

, 2018
Clusters of IP3 receptor channels in the membranes of the endoplasmic reticulum (ER) of many non-excitable cells release calcium ions in a cooperative manner giving rise to dynamical patterns such as Ca2+ puffs, waves, and oscillations that occur on ...
Bhaskar, Atul, Braichenko, Svitlana, Dasmahapatra, Srinandan   +2 more
core   +2 more sources

Tissue-specific expression of high-voltage-activated dihydropyridine-sensitive L-type calcium channels [PDF]

, 1991
The cloning of the cDNA for the α1 subunit of L-type calcium channels revealed that at least two genes (CaCh1 and CaCh2) exist which give rise to several splice variants.
Caffrey J. M., Catterall W. A., Ellis S. B., Glossmann H., Grabner M., Hofmann F., Hoshi T., Jay S. D., Jongh K. S., Kim H. S., Koch W. J., Koch W. J., Melton D. A., Olson E. N., Perez-Reyes E., Rampe D. E., Reuter H., Ruth P., Ruth P., Sambrook J., Sanger F., Schubert D., Shih H.-T., Snutch T. P., Tanabe T., Thomas P. S., Tsien R. W.   +26 more
core   +2 more sources

Calcium Channel Blockers

Medical Clinics of North America, 1988
The calcium channel blockers initially were approved for the treatment of classical and variant angina pectoris. Recent studies indicate that these agents also are useful in such diverse conditions as pulmonary and systemic hypertension, hypertrophic cardiomyopathy, arrhythmias, asthma, Raynaud's syndrome, esophageal spasm, myometrial hyperactivity ...
openaire   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Calcium Channels [PDF]

Nature, 1988
H, Glossmann, J, Striessnig
openaire   +4 more sources

Hysteresis and bi-stability by an interplay of calcium oscillations and action potential firing

, 2006
Many cell types exhibit oscillatory activity, such as repetitive action potential firing due to the Hodgkin-Huxley dynamics of ion channels in the cell membrane or reveal intracellular inositol triphosphate (IP$_3$) mediated calcium oscillations (CaOs ...
A. P. R. Theuvenet, C. C. A. M. Gielen, D. L. Ypey, J. Guckenheimer, J. M. A. M. Kusters, J. M. Cortes, J. D. Murray, O. Aslanidi, T. R. Chay, W. P. M. van Meerwijk   +9 more
core   +1 more source

Voltage-gated calcium channels and their auxiliary subunits: physiology and pathophysiology and pharmacology [PDF]

, 2016
Voltage-gated calcium channels are essential players in many physiological processes in excitable cells. There are three main subdivisions of calcium channel, defined by the pore-forming α1 subunit, the CaV 1, CaV 2 and CaV 3 channels.
Dolphin, AC
core   +1 more source