Results 101 to 110 of about 475,886 (304)

Junctate is a key element in calcium entry induced by activation of InsP3 receptors and/or calcium store depletion [PDF]

, 2004
In many cell types agonist-receptor activation leads to a rapid and transient release of Ca(2+) from intracellular stores via activation of inositol 1,4,5 trisphosphate (InsP(3)) receptors (InsP(3)Rs).
Treves, Susan, Franzini-Armstrong, Clara, Moccagatta, Luca, Arnoult, Christophe, Grasso, Cristiano, Schrum, Adam, Ducreux, Sylvie, Zhu, Michael X., Mikoshiba, Katsuhiko, Girard, Thierry, Smida-Rezgui, Sophia, Ronjat, Michel, Zorzato, Francesco   +12 more
core   +3 more sources

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Role of calcium-activated potassium channels in the heart

Cardiology Plus, 2017
Ability of intracellular calcium to open K+-selective channels in an excitable membrane and to hasten repolarization of an action potential or inhibit firing is a fundamental principle of biology first recognized in the mid-1970s. There are several types
William T Clusin
doaj   +1 more source

Modulation of neural cell membrane conductance by the herbal anxiolytic and antiepileptic drug aswal [PDF]

, 2000
To evaluate the effects of aswal on ionic fluxes and neuronal excitation, we performed extracellular and whole cell patch clamp recordings on CA1 pyramidal neurons of guinea pigs and Long-Evans rats.
Grunze, Heinz, Langosch, J., Loewenich, C. von, Walden, Jörg   +3 more
core   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

A nongenomic mechanism for progesterone-mediated immunosuppression: Inhibition of K+ channels, Ca2+ signaling, and gene expression in T lymphocytes [PDF]

, 1998
The mechanism by which progesterone causes localized suppression of the immune response during pregnancy has remained elusive. Using human T lymphocytes and T cell lines, we show that progesterone, at concentrations found in the placenta, rapidly and ...
Beer, Bergeron, Bertrand, Bielefeldt, Blackmore, Breit, Cahalan, Cahalan, Chandy, Clemens, Crabtree, Dolmetsch, Fiering, Foresta, Gouy, Grissmer, Grynkiewicz, Gurka, Hamill, Hess, Horn, Hunt, Karttunen, Kerschbaum, Koo, Lewis, Lewis, Lin, Logsdon, Mason, Michne, Monterroso, Negulescu, Nguyen, Pavia, Pepe, Phipps, Premack, Price, Revelli, Roussev, Runnebaum, Runnebaum, Shastri, Siiteri, Siiteri, Stites, Thastrup, Timmerman, Valera, Van Voorhis, Verheugen, Waldegger, Wu, Zweifach   +54 more
core   +2 more sources

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Overexpression of Large-Conductance Calcium-Activated Potassium Channels in Human Glioblastoma Stem-Like Cells and Their Role in Cell Migration [PDF]

, 2017
Glioblastomas (GBMs) are brain tumors characterized by diffuse invasion of cancer cells into the healthy brain parenchyma, and establishment of secondary foci. GBM cells abundantly express large-conductance, calcium-activated potassium (BK) channels that
Abdullaev, Bao, Bednarczyk, Beier, Brenner, Brescia, Buttigieg, Calogero, Catacuzzeno, Catacuzzeno, Catacuzzeno, Catacuzzeno, Chen, Choy, Cuddapah, Eckel-Passow, Edalat, Eskandari, Fioretti, Fioretti, Gu, Holland, Inoue, Kyle, Liu, Maher, Maugeri-Saccà, Maugeri-Saccà, McFerrin, Meera, Park, Ransom, Ruggieri, Sforna, Sforna, Shruti, Siemen, Sontheimer, Soria, Soroceanu, Steinle, Torres, Turner, Wang, Weaver, Weiger, Wondergem, Wu, Yu, Zhang   +49 more
core   +1 more source

Calcium Channel Auxiliary Subunits

Microbial Physiology, 2006
Many channels and carriers associate with auxiliary subunits which modify their activities and facilitate biogenesis. Advances in genome sequencing as well as biochemical, molecular genetic, and physiological experimentation have allowed for the discovery of many transport auxiliary subunits.
Tsai-Tien, Tseng, Allison M, McMahon, Robert J, Zahm, Mary E, Pacold, Eric, Jakobsson   +4 more
openaire   +2 more sources