Results 1 to 10 of about 192,611 (304)
Frontiers in Synaptic Neuroscience, 2021 The loss of dopamine (DA)-producing neurons in the substantia nigra pars compacta (SN) underlies the core motor symptoms of the progressive movement disorder Parkinson's disease (PD).
Nadine J. Ortner
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Function, 2022 In many cell types, the rise in cytosolic Ca2+ due to opening of Ca2+ release-activated Ca2+ (CRAC) channels drives a plethora of responses, including secretion, motility, energy production, and gene expression.
Pradeep Barak +4 more
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Frontiers in Physiology, 2022 Biochemical and functional studies of ion channels have shown that many of these integral membrane proteins form macromolecular signaling complexes by physically associating with many other proteins.
Kunal R. Shah +4 more
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Calcium-Dependent Ion Channels and the Regulation of Arteriolar Myogenic Tone
Frontiers in Physiology, 2021 Arterioles in the peripheral microcirculation regulate blood flow to and within tissues and organs, control capillary blood pressure and microvascular fluid exchange, govern peripheral vascular resistance, and contribute to the regulation of blood ...
William F. Jackson
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TRPC1 channels underlie stretch-modulated sarcoplasmic reticulum calcium leak in cardiomyocytes
Frontiers in Physiology, 2022 Transient receptor potential canonical 1 (TRPC1) channels are Ca2+-permeable ion channels expressed in cardiomyocytes. An involvement of TRPC1 channels in cardiac diseases is widely established.
Molly E. Streiff +8 more
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Calcium signaling and transport machinery: Potential for development of stress tolerance in plants
Current Plant Biology, 2022 Calcium (Ca2+) is an essential macronutrient as well as a second messenger in diverse biological processes in plants. Plants perceive various stimuli which leads to transient increase in cytosolic calcium [Ca2+]cyt levels, resulting in generation of Ca2+
Soma Ghosh +3 more
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Apamin Boosting of Synaptic Potentials in CaV2.3 R-Type Ca2+ Channel Null Mice. [PDF]
PLoS ONE, 2015 SK2- and KV4.2-containing K+ channels modulate evoked synaptic potentials in CA1 pyramidal neurons. Each is coupled to a distinct Ca2+ source that provides Ca2+-dependent feedback regulation to limit AMPA receptor (AMPAR)- and NMDA receptor (NMDAR ...
Kang Wang +4 more
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How Merkel cells transduce mechanical stimuli: A biophysical model of Merkel cells.
PLoS Computational Biology, 2023 Merkel cells combine with Aβ afferents, producing slowly adapting type 1(SA1) responses to mechanical stimuli. However, how Merkel cells transduce mechanical stimuli into neural signals to Aβ afferents is still unclear.
Fangtao Mao, Wenzhen Yang
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Ca2+ Dependence of the Ca2+-selective TRPV6 Channel [PDF]
Journal of Biological Chemistry, 2004 Microfluorimetry and patch-clamp experiments were performed on TRPV6-expressing HEK cells to determine whether this Ca(2+)-sensing Ca(2+) channel is constitutively active. Intact cells loaded with fura-2 had an elevated intracellular free Ca(2+) concentration ([Ca(2+)](i)), which decreased to the same level such as in non-transfected cells if external ...
Matthias, Bödding, Veit, Flockerzi
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The Physiopathologic Roles of Calcium Signaling in Podocytes
Frontiers in Bioscience-Landmark, 2023 Calcium (Ca2+) plays a critical role in podocyte function. The Ca2+-sensitive receptors on the cell surface can sense changes in Ca2+ concentration, and Ca2+ flow into podocytes, after activation of Ca2+ channels (such as transient receptor potential ...
Yu-Chi Tu +6 more
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