Results 1 to 10 of about 300,266 (188)

Voltage-Gated Ca2+ Channels in Dopaminergic Substantia Nigra Neurons: Therapeutic Targets for Neuroprotection in Parkinson's Disease?

Frontiers in Synaptic Neuroscience, 2021
The loss of dopamine (DA)-producing neurons in the substantia nigra pars compacta (SN) underlies the core motor symptoms of the progressive movement disorder Parkinson's disease (PD).
Nadine J. Ortner
doaj   +1 more source

Structural and Functional Coupling of Calcium-Activated BK Channels and Calcium-Permeable Channels Within Nanodomain Signaling Complexes

Frontiers in Physiology, 2022
Biochemical and functional studies of ion channels have shown that many of these integral membrane proteins form macromolecular signaling complexes by physically associating with many other proteins.
Kunal R. Shah, Xin Guan, Jiusheng Yan, Jiusheng Yan, Jiusheng Yan   +4 more
doaj   +1 more source

Plasma Membrane Ca2+ ATPase Activity Enables Sustained Store-operated Ca2+ Entry in the Absence of a Bulk Cytosolic Ca2+ Rise

Function, 2022
In many cell types, the rise in cytosolic Ca2+ due to opening of Ca2+ release-activated Ca2+ (CRAC) channels drives a plethora of responses, including secretion, motility, energy production, and gene expression.
Pradeep Barak, Suneet Kaur, Erica Scappini, Charles J Tucker, Anant B Parekh   +4 more
doaj   +1 more source

Calcium-Dependent Ion Channels and the Regulation of Arteriolar Myogenic Tone

Frontiers in Physiology, 2021
Arterioles in the peripheral microcirculation regulate blood flow to and within tissues and organs, control capillary blood pressure and microvascular fluid exchange, govern peripheral vascular resistance, and contribute to the regulation of blood ...
William F. Jackson
doaj   +1 more source

TRPC1 channels underlie stretch-modulated sarcoplasmic reticulum calcium leak in cardiomyocytes

Frontiers in Physiology, 2022
Transient receptor potential canonical 1 (TRPC1) channels are Ca2+-permeable ion channels expressed in cardiomyocytes. An involvement of TRPC1 channels in cardiac diseases is widely established.
Molly E. Streiff, Molly E. Streiff, Andrea C. Corbin, Andrea C. Corbin, Azmi A. Ahmad, Azmi A. Ahmad, Chris Hunter, Frank B. Sachse, Frank B. Sachse   +8 more
doaj   +1 more source

Calcium signaling and transport machinery: Potential for development of stress tolerance in plants

Current Plant Biology, 2022
Calcium (Ca2+) is an essential macronutrient as well as a second messenger in diverse biological processes in plants. Plants perceive various stimuli which leads to transient increase in cytosolic calcium [Ca2+]cyt levels, resulting in generation of Ca2+
Soma Ghosh, Malathi Bheri, Diksha Bisht, Girdhar K. Pandey   +3 more
doaj   +1 more source

Apamin Boosting of Synaptic Potentials in CaV2.3 R-Type Ca2+ Channel Null Mice. [PDF]

PLoS ONE, 2015
SK2- and KV4.2-containing K+ channels modulate evoked synaptic potentials in CA1 pyramidal neurons. Each is coupled to a distinct Ca2+ source that provides Ca2+-dependent feedback regulation to limit AMPA receptor (AMPAR)- and NMDA receptor (NMDAR ...
Kang Wang, Melissa H Kelley, Wendy W Wu, John P Adelman, James Maylie   +4 more
doaj   +1 more source

How Merkel cells transduce mechanical stimuli: A biophysical model of Merkel cells.

PLoS Computational Biology, 2023
Merkel cells combine with Aβ afferents, producing slowly adapting type 1(SA1) responses to mechanical stimuli. However, how Merkel cells transduce mechanical stimuli into neural signals to Aβ afferents is still unclear.
Fangtao Mao, Wenzhen Yang
doaj   +1 more source

Kv2.1 channels play opposing roles in regulating membrane potential, Ca2+ channel function, and myogenic tone in arterial smooth muscle. [PDF]

, 2020
The accepted role of the protein Kv2.1 in arterial smooth muscle cells is to form K+ channels in the sarcolemma. Opening of Kv2.1 channels causes membrane hyperpolarization, which decreases the activity of L-type CaV1.2 channels, lowering intracellular ...
Guarina, Laura, Klug, Nicholas R, Matsumoto, Collin, McKinnon, David, O'Dwyer, Samantha C, Palacio, Stephanie, Rosati, Barbara, Santana, L Fernando, Tajada, Sendoa, Trimmer, James S   +9 more
core   +3 more sources

A nongenomic mechanism for progesterone-mediated immunosuppression: Inhibition of K+ channels, Ca2+ signaling, and gene expression in T lymphocytes [PDF]

, 1998
The mechanism by which progesterone causes localized suppression of the immune response during pregnancy has remained elusive. Using human T lymphocytes and T cell lines, we show that progesterone, at concentrations found in the placenta, rapidly and ...
Beer, Bergeron, Bertrand, Bielefeldt, Blackmore, Breit, Cahalan, Cahalan, Chandy, Clemens, Crabtree, Dolmetsch, Fiering, Foresta, Gouy, Grissmer, Grynkiewicz, Gurka, Hamill, Hess, Horn, Hunt, Karttunen, Kerschbaum, Koo, Lewis, Lewis, Lin, Logsdon, Mason, Michne, Monterroso, Negulescu, Nguyen, Pavia, Pepe, Phipps, Premack, Price, Revelli, Roussev, Runnebaum, Runnebaum, Shastri, Siiteri, Siiteri, Stites, Thastrup, Timmerman, Valera, Van Voorhis, Verheugen, Waldegger, Wu, Zweifach   +54 more
core   +3 more sources