Results 31 to 40 of about 31,767 (201)

Low-voltage-activated Ca²+ channels. from burst generators to Ca²+ sources in thalamic oscillatory activity [PDF]

, 2007
Ca2+ ions play key signalling roles in all fundamental neurophysiological processes. The diversity of these roles is accomplished with astounding specificity, velocity and flexibility.
Cueni, Lucius D.
core   +1 more source

Tweeters and Woofers: The Complex Orchestra of Calcium Currents in T Lymphocytes

Frontiers in Immunology, 2015
Elevation of intracellular calcium ion (Ca2+) levels is a vital event that regulates T lymphocyte homeostasis, activation, proliferation, differentiation, and apoptosis.
Lilian L Nohara, Lilian L Nohara, Shawna R Stanwood, Shawna R Stanwood, Kyla D Omilusik, Kyla D Omilusik, Kyla D Omilusik, Wilfred A Jefferies, Wilfred A Jefferies, Wilfred A Jefferies, Wilfred A Jefferies, Wilfred A Jefferies, Wilfred A Jefferies   +12 more
doaj   +1 more source

Ryanodine receptors, a family of intracellular calcium ion channels, are expressed throughout early vertebrate development [PDF]

, 2011
Background Calcium signals ([Ca2+]i) direct many aspects of embryo development but their regulation is not well characterised. Ryanodine receptors (RyRs) are a family of intracellular Ca2+ release channels that control the flux of Ca2+ from internal ...
Ashworth, R, Rachel Ashworth, Brennan Caroline, Wu Houdini HT, Brennan, C, Wu, HH, Ashworth Rachel, Caroline Brennan, Houdini HT Wu   +8 more
core   +1 more source

New Insights Into Interactions of Presynaptic Calcium Channel Subtypes and SNARE Proteins in Neurotransmitter Release

Frontiers in Molecular Neuroscience, 2018
Action potential (AP) induces presynaptic membrane depolarization and subsequent opening of Ca2+ channels, and then triggers neurotransmitter release at the active zone of presynaptic terminal.
Rongfang He, Rongfang He, Juan Zhang, Yiyan Yu, Laluo Jizi, Weizhong Wang, Miaoling Li   +6 more
doaj   +1 more source

Bound Ca2+ moves faster and farther from single open channels than free Ca2+ [PDF]

, 2023
A concept of Ca2+ nanodomains established in the cytoplasm after opening single-calcium channels helps mechanistically understand the physiological mechanisms of Ca2+ signaling.
S. L. Mironov, Mironov, Sergej L.
core   +1 more source

The Complex Role of Store Operated Calcium Entry Pathways and Related Proteins in the Function of Cardiac, Skeletal and Vascular Smooth Muscle Cells

Frontiers in Physiology, 2018
Cardiac, skeletal, and smooth muscle cells shared the common feature of contraction in response to different stimuli. Agonist-induced muscle's contraction is triggered by a cytosolic free Ca2+ concentration increase due to a rapid Ca2+ release from ...
Javier Avila-Medina, Javier Avila-Medina, Javier Avila-Medina, Isabel Mayoral-Gonzalez, Isabel Mayoral-Gonzalez, Alejandro Dominguez-Rodriguez, Alejandro Dominguez-Rodriguez, Alejandro Dominguez-Rodriguez, Isabel Gallardo-Castillo, Juan Ribas, Antonio Ordoñez, Antonio Ordoñez, Juan A. Rosado, Tarik Smani, Tarik Smani, Tarik Smani   +15 more
doaj   +1 more source

Calcium Signals from the Vacuole

Plants, 2013
The vacuole is by far the largest intracellular Ca2+ store in most plant cells. Here, the current knowledge about the molecular mechanisms of vacuolar Ca2+ release and Ca2+ uptake is summarized, and how different vacuolar Ca2+ channels and Ca2+ pumps may
Gerald Schönknecht
doaj   +1 more source

Endothelin-Induced Sarcoplasmic Reticulum Calcium Depletion Waves in Vascular Smooth Muscle Cells [PDF]

, 2011
Agonist-stimulated waves of elevated cytoplasmic Ca2+ concentration ([Ca2+]i ) regulate blood vessel tone and vasomotion in vascular smooth muscle. Previous studies employing cytoplasmic Ca2+ indicators revealed that these Ca2+ waves were generated by a ...
Cornelis van Breemen, Jeremy Hoskins, Arash Y. Tehrani, Mitra Esfandiarei, Yohan Choi, Nicola Fameli, Jeremy G. Hoskins, Arash Tehrani   +7 more
core   +1 more source

Pancreatic β Cell CaV Channels in Health and Disease

, 2022
Multiple types of voltage-gated calcium (CaV) channels including CaV1.2, CaV1.3, CaV2.1, CaV2.2, CaV2.3, CaV3.1, and CaV3.2 operate in electrically excitable β cells under both physiological and pathophysiological conditions.
Berggren, P-O, Yang, S-N, Yu, J, Zhao, K, Yang, G, Shi, Y   +5 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source