The Physiopathologic Roles of Calcium Signaling in Podocytes
Frontiers in Bioscience-Landmark, 2023 Calcium (Ca2+) plays a critical role in podocyte function. The Ca2+-sensitive receptors on the cell surface can sense changes in Ca2+ concentration, and Ca2+ flow into podocytes, after activation of Ca2+ channels (such as transient receptor potential ...
Yu-Chi Tu +6 more
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Regenerative Calcium Currents in Renal Primary Cilia
Frontiers in Physiology, 2022 Polycystic kidney disease (PKD) is a leading cause of end-stage renal disease. PKD arises from mutations in proteins, one a Ca2+-conducting channel, expressed in the primary cilia of renal epithelial cells.
Steven J. Kleene
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Involvement of calcium channels in the regulation of adipogenesis
Adipocyte, 2020 As an important second messenger in adipocytes, calcium ions (Ca2+) are essential in regulating various intracellular signalling pathways that control critical cellular functions.
Mingzhu Zhai +3 more
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Phase 1 repolarization rate defines Ca2+ dynamics and contractility on intact mouse hearts. [PDF]
, 2019 In the heart, Ca2+ influx through L-type Ca2+ channels triggers Ca2+ release from the sarcoplasmic reticulum. In most mammals, this influx occurs during the ventricular action potential (AP) plateau phase 2.
Escobar, Ariel L +4 more
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TRP Channels Mediated Pathological Ca2+-Handling and Spontaneous Ectopy
Frontiers in Cardiovascular Medicine, 2019 Ion channel biology offers great opportunity in identifying and learning about cardiac pathophysiology mechanisms. The discovery of transient receptor potential (TRP) channels is an add-on to the opportunity. Interacting with numerous signaling pathways,
Martin Ezeani
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The mechanisms of calcium homeostasis and signalling in the lens [PDF]
, 2008 Excessive Ca2+ can be detrimental to cells and raised levels of Ca2+ in human lenses with cortical cataract have been found to play a major role in the opacification process.
Rhodes, JD, Sanderson, J
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ER localized bestrophin1 activates Ca2+ dependent ion channels TMEM16A and SK4 [PDF]
, 2009 Bestrophins form Ca2+ activated Cl- channels and regulate intercellular Ca2+ signaling1. We demonstrate that bestrophin 1 is localized in the endoplasmic reticulum (ER), where it physically interacts with stromal interacting molecule 1 (Stim1), the ER ...
Fadi AlDehni +6 more
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Calcium channels and transporters: Roles in response to biotic and abiotic stresses
Frontiers in Plant Science, 2022 Calcium (Ca2+) serves as a ubiquitous second messenger by mediating various signaling pathways and responding to numerous environmental conditions in eukaryotes.
Chang-Jin Park, Ryoung Shin
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Ontogeny of purinergic receptor-regulated Ca2+ signaling in mouse cortical collecting duct epithelium [PDF]
, 2002 Changes in ATP-induced increase in {[}Ca2+], during collecting duct ontogeny were studied in primary monolayer cultures of mouse ureteric bud (UB) and cortical collecting duct (CCD) cells by Fura-PE3 fluorescence ratio imaging.
Borscheid, R. +4 more
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Pathophysiological Significance of T-type Ca2+ Channels: T-type Ca2+ Channels and Drug Development
Journal of Pharmacological Sciences, 2005 T-type Ca2+ channels are present in cardiovascular, neuronal, and endocrine systems; and they are now receiving attention as novel therapeutic targets. Many drugs and compounds non-specificaly block T-type Ca2+ channels. Certain dihydropyridine compounds,
Hikaru Tanaka, Koki Shigenobu
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