Ca2+ entry through NaV channels generates submillisecond axonal Ca2+ signaling
eLife, 2020 Calcium ions (Ca2+) are essential for many cellular signaling mechanisms and enter the cytosol mostly through voltage-gated calcium channels. Here, using high-speed Ca2+ imaging up to 20 kHz in the rat layer five pyramidal neuron axon we found that ...
Naomi AK Hanemaaijer +5 more
doaj +2 more sources
Structure and function of potassium and calcium channels [PDF]
, 2005 In this thesis, potassium channels human Kv2.1 and rat Kv2.1, along with calcium channels Ca, 1.2, Ca, 3.1, and chimeras have been studied. These channels were expressed in Xenopuso ocytesf or electrophysiological experiments using two electrode voltage
Stevens, Louisa Rebecca
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Regenerative Calcium Currents in Renal Primary Cilia
Frontiers in Physiology, 2022 Polycystic kidney disease (PKD) is a leading cause of end-stage renal disease. PKD arises from mutations in proteins, one a Ca2+-conducting channel, expressed in the primary cilia of renal epithelial cells.
Steven J. Kleene
doaj +1 more source
Involvement of calcium channels in the regulation of adipogenesis
Adipocyte, 2020 As an important second messenger in adipocytes, calcium ions (Ca2+) are essential in regulating various intracellular signalling pathways that control critical cellular functions.
Mingzhu Zhai +3 more
doaj +1 more source
ER localized bestrophin1 activates Ca2+ dependent ion channels TMEM16A and SK4 [PDF]
, 2009 Bestrophins form Ca2+ activated Cl- channels and regulate intercellular Ca2+ signaling1. We demonstrate that bestrophin 1 is localized in the endoplasmic reticulum (ER), where it physically interacts with stromal interacting molecule 1 (Stim1), the ER ...
Rainer Schreiber +13 more
core +1 more source
TRP Channels Mediated Pathological Ca2+-Handling and Spontaneous Ectopy
Frontiers in Cardiovascular Medicine, 2019 Ion channel biology offers great opportunity in identifying and learning about cardiac pathophysiology mechanisms. The discovery of transient receptor potential (TRP) channels is an add-on to the opportunity. Interacting with numerous signaling pathways,
Martin Ezeani
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Functional expression of TRPV4 channels in human collecting duct cells : implications for secondary hypertension in diabetic nephropathy [PDF]
, 2012 Background. The Vanilloid subfamily of transient receptor potential (TRPV) ion channels has been widely implicated in detecting osmotic and mechanical stress.
Hills, Claire E. +2 more
core +1 more source
The self-maintaining nature of ventricular fibrillation : contribution of L-type Ca²+ channels and Na+/Ca²+ exchange to cardiomyocyte Ca²+ overload in ventricular fibrillation : surface fluorescence study in isolated perfused rat hearts [PDF]
, 2004 Approximately 40% of all deaths in Switzerland are due to cardiovascular diseases.1 An important part of these deaths happen because of life-threatening cardiac arrhythmias.
Driamov, Sergey
core +1 more source
Imaging large cohorts of single ion channels and their activity [PDF]
, 2013 As calcium is the most important signaling molecule in neurons and secretory cells, amongst many other cell types, it follows that an understanding of calcium channels and their regulation of exocytosis is of vital importance.
Euan R. Brown +8 more
core +1 more source
TRPC5 Is a Ca2+-activated Channel Functionally Coupled to Ca2+-selective Ion Channels [PDF]
Journal of Biological Chemistry, 2009 TRPC5 forms non-selective cation channels. Here we studied the role of internal Ca(2+) in the activation of murine TRPC5 heterologously expressed in human embryonic kidney cells. Cell dialysis with various Ca(2+) concentrations (Ca(2+)(i)) revealed a dose-dependent activation of TRPC5 channels by internal Ca(2+) with EC(50) of 635.1 and 358.2 nm at ...
Stefan Alfred, Gross +6 more
openaire +2 more sources