Pathophysiological Significance of T-type Ca2+ Channels: T-type Ca2+ Channels and Drug Development
Journal of Pharmacological Sciences, 2005 T-type Ca2+ channels are present in cardiovascular, neuronal, and endocrine systems; and they are now receiving attention as novel therapeutic targets. Many drugs and compounds non-specificaly block T-type Ca2+ channels. Certain dihydropyridine compounds,
Hikaru Tanaka, Koki Shigenobu
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Ca2+ entry through NaV channels generates submillisecond axonal Ca2+ signaling
eLife, 2020 Calcium ions (Ca2+) are essential for many cellular signaling mechanisms and enter the cytosol mostly through voltage-gated calcium channels. Here, using high-speed Ca2+ imaging up to 20 kHz in the rat layer five pyramidal neuron axon we found that ...
Naomi AK Hanemaaijer +5 more
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Swelling-activated Ca2+ channels trigger Ca2+ signals in Merkel cells.
PLoS ONE, 2008 Merkel cell-neurite complexes are highly sensitive touch receptors comprising epidermal Merkel cells and sensory afferents. Based on morphological and molecular studies, Merkel cells are proposed to be mechanosensory cells that signal afferents via ...
Henry Haeberle +4 more
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Ca2+-Sensitive Potassium Channels
, 2023 The Ca2+ ion is used ubiquitously as an intracellular signaling molecule due to its high external and low internal concentration. Many Ca2+-sensing ion channel proteins have evolved to receive and propagate Ca2+ signals. Among them are the Ca2+-activated
Albanyan, Nora +3 more
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ER localized bestrophin1 activates Ca2+ dependent ion channels TMEM16A and SK4 [PDF]
, 2009 Bestrophins form Ca2+ activated Cl- channels and regulate intercellular Ca2+ signaling1. We demonstrate that bestrophin 1 is localized in the endoplasmic reticulum (ER), where it physically interacts with stromal interacting molecule 1 (Stim1), the ER ...
Rainer Schreiber +13 more
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TRP Channels Mediated Pathological Ca2+-Handling and Spontaneous Ectopy
Frontiers in Cardiovascular Medicine, 2019 Ion channel biology offers great opportunity in identifying and learning about cardiac pathophysiology mechanisms. The discovery of transient receptor potential (TRP) channels is an add-on to the opportunity. Interacting with numerous signaling pathways,
Martin Ezeani
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Involvement of calcium channels in the regulation of adipogenesis
Adipocyte, 2020 As an important second messenger in adipocytes, calcium ions (Ca2+) are essential in regulating various intracellular signalling pathways that control critical cellular functions.
Mingzhu Zhai +3 more
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The self-maintaining nature of ventricular fibrillation : contribution of L-type Ca²+ channels and Na+/Ca²+ exchange to cardiomyocyte Ca²+ overload in ventricular fibrillation : surface fluorescence study in isolated perfused rat hearts [PDF]
, 2004 Approximately 40% of all deaths in Switzerland are due to cardiovascular diseases.1 An important part of these deaths happen because of life-threatening cardiac arrhythmias.
Driamov, Sergey
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, 1998 1. The effects of inhibitors of ryanodine-sensitive calcium release (RyR) channels in the sarcoplasmic reticulum (SR) and Ca2+-dependent potassium (K(Ca)) channels on the membrane potential, intracellular [Ca2+], and diameters of small pressurized (60 ...
Knot, Harm J. +2 more
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Functional expression of TRPV4 channels in human collecting duct cells : implications for secondary hypertension in diabetic nephropathy [PDF]
, 2012 Background. The Vanilloid subfamily of transient receptor potential (TRPV) ion channels has been widely implicated in detecting osmotic and mechanical stress.
Hills, Claire E. +2 more
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