Results 21 to 30 of about 192,611 (304)
Calcium channels and transporters: Roles in response to biotic and abiotic stresses
Frontiers in Plant Science, 2022 Calcium (Ca2+) serves as a ubiquitous second messenger by mediating various signaling pathways and responding to numerous environmental conditions in eukaryotes.
Chang-Jin Park, Ryoung Shin
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Ca2+-dependent modulation of voltage-gated Ca2+ channels [PDF]
Biochimica et Biophysica Acta (BBA) - General Subjects, 2012 Voltage-gated (Cav) Ca2+ channels are multi-subunit complexes that play diverse roles in a wide variety of tissues. A fundamental mechanism controlling Cav channel function involves the Ca2+ ions that permeate the channel pore. Ca2+ influx through Cav channels mediates feedback regulation to the channel that is both negative (Ca2+-dependent ...
Carl, Christel, Amy, Lee
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FMI-43 is a permeant blocker of mechanosensitive ion channels in sensory neurons and inhibits behavioural responses to mechanical stimuli [PDF]
, 2007 The molecular identity and pharmacological properties of mechanically gated ion channels in sensory neurons are poorly understood. We show that FM1-43, a styryl dye used to fluorescently label cell membranes, permeates mechanosensitive ion channels in ...
Wood John N +7 more
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Pathophysiological Significance of T-type Ca2+ Channels: T-type Ca2+ Channels and Drug Development
Journal of Pharmacological Sciences, 2005 T-type Ca2+ channels are present in cardiovascular, neuronal, and endocrine systems; and they are now receiving attention as novel therapeutic targets. Many drugs and compounds non-specificaly block T-type Ca2+ channels. Certain dihydropyridine compounds,
Hikaru Tanaka, Koki Shigenobu
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Kv7 and Kv11 channels in myometrial regulation. [PDF]
, 2013 Ion channels play a key role in defining myometrial contractility. Modulation of ion channel populations is proposed to underpin gestational changes in uterine contractility associated with the transition from uterine quiescence to active labour.
Tribe, Rachel M; id_orcid +5 more
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Ca2+-Calmodulin-dependent Facilitation and Ca2+ Inactivation of Ca2+ Release-activated Ca2+ Channels [PDF]
Journal of Biological Chemistry, 2005 In non-excitable cells, one major route for Ca2+ influx is through store-operated Ca2+ channels in the plasma membrane. These channels are activated by the emptying of intracellular Ca2+ stores, and in some cell types store-operated influx occurs through Ca2+ release-activated Ca2+ (CRAC) channels. Here, we report that intracellular Ca2+ modulates CRAC
Ben, Moreau +4 more
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Molecular Basis for CA2+ Channel Diversity [PDF]
Annual Review of Neuroscience, 1994 Neurotransmitter release, neurosecretion, neuronal excitation, survival of neurons, and many other neuronal functions are controlled by the cellular calcium concentration. Calcium entry across the plasma membrane in response to membrane depolarization or activation of neurotransmitter receptors repre sents a major pathway for the cellular control of ...
Hofmann, Franz +2 more
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Activity-dependent regulation of T-type calcium channels by submembrane calcium ions
eLife, 2017 Voltage-gated Ca2+ channels are involved in numerous physiological functions and various mechanisms finely tune their activity, including the Ca2+ ion itself.
Magali Cazade +3 more
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The role of ryanodine receptors in development [PDF]
, 2011 PhDCalcium ions (Ca2+) are fundamental to the regulation of many cellular processes; however, the coordination of these signals during embryogenesis is not well understood.
Wu, Houdini Ho-Tin
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Ca2+ Signaling in Cardiac Fibroblasts and Fibrosis-Associated Heart Diseases
Journal of Cardiovascular Development and Disease, 2019 Cardiac fibrosis is the excessive deposition of extracellular matrix proteins by cardiac fibroblasts and myofibroblasts, and is a hallmark feature of most heart diseases, including arrhythmia, hypertrophy, and heart failure.
Jianlin Feng +5 more
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