Results 51 to 60 of about 3,593,980 (394)

Store-operated calcium channels in skin

open access: yesFrontiers in Physiology, 2022
The skin is a complex organ that acts as a protective layer against the external environment. It protects the internal tissues from harmful agents, dehydration, ultraviolet radiation and physical injury as well as conferring thermoregulatory control ...
Declan Manning   +3 more
doaj   +1 more source

Energetics of discrete selectivity bands and mutation-induced transitions in the calcium-sodium ion channels family [PDF]

open access: yes, 2013
We use Brownian dynamics (BD) simulations to study the ionic conduction and valence selectivity of a generic electrostatic model of a biological ion channel as functions of the fixed charge Qf at its selectivity filter.
Eisenberg, Robert S.   +4 more
core   +2 more sources

Cavβ surface charged residues contribute to the regulation of neuronal calcium channels

open access: yesMolecular Brain, 2022
Voltage-gated calcium channels are essential regulators of brain function where they support depolarization-induced calcium entry into neurons. They consist of a pore-forming subunit (Cavα1) that requires co-assembly with ancillary subunits to ensure ...
Alexandra Tran-Van-Minh   +2 more
doaj   +1 more source

A functional role for small-conductance calcium-activated potassium channels in sensory pathways including nociceptive processes [PDF]

open access: yes, 2005
We investigated the role of small-conductance calcium-activated potassium (SK) and intermediate-conductance calcium-activated potassium channels in modulating sensory transmission from peripheral afferents into the rat spinal cord.
Bahia, PK   +7 more
core   +1 more source

Focused ultrasound excites cortical neurons via mechanosensitive calcium accumulation and ion channel amplification

open access: yesNature Communications, 2022
Ultrasonic neuromodulation has the unique potential to provide non-invasive control of neural activity in deep brain regions with high spatial precision and without chemical or genetic modification.
Sangjin Yoo   +4 more
semanticscholar   +1 more source

Suramin-Induced Neurotoxicity: Preclinical Models and Neuroprotective Strategies

open access: yesMolecules, 2018
Suramin is a trypan blue analogon originally developed to treat protozoan infections, which was found to have diverse antitumor effects. One of the most severe side effects in clinical trials was the development of a peripheral sensory-motor ...
David von der Ahe   +5 more
doaj   +1 more source

CaV1 and CaV2 calcium channels mediate the release of distinct pools of synaptic vesicles

open access: yeseLife, 2023
Activation of voltage-gated calcium channels at presynaptic terminals leads to local increases in calcium and the fusion of synaptic vesicles containing neurotransmitter.
Brian D Mueller   +12 more
doaj   +1 more source

Photoinduced Removal of Nifedipine Reveals Mechanisms of Calcium Antagonist Action on Single Heart Cells [PDF]

open access: yes, 1985
The currents through voltage-activated calcium channels in heart cell membranes are suppressed by dihydropyridine calcium antagonists such as nifedipine.
Gurney, Alison M.   +2 more
core   +2 more sources

TRP channels in microglia: role in physiology and disease

open access: yesFrontiers in Cellular Neuroscience, 2015
Microglia are responsible for modulating the cellular environment in the nervous system, where they have neuroprotective effects. In these cells has been reported the expression of different ion channels, including those belonging to the transient ...
Yolima P Torres
doaj   +1 more source

The involvement of actin, calcium channels and exocytosis proteins in somato-dendritic oxytocin and vasopressin release [PDF]

open access: yes, 2012
Hypothalamic magnocellular neurons release vasopressin and oxytocin not only from their axon terminals into the blood, but also from their somata and dendrites into the extracellular space of the brain, and this can be regulated independently ...
Leng, Gareth, Ludwig, Mike, Tobin, Vicky
core   +2 more sources

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