Optimal intracellular calcium signaling [PDF]
, 2002 In many cell types, calcium is released from internal stores through calcium release channels upon external stimulation (e.g., pressure or receptor binding), These channels are clustered with a typical cluster size of about 20 channels, generating ...
Jung, P., Shuai, J. W., 帅建伟
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Role of Calcium Permeable Channels in Pain Processing [PDF]
, 2018 Calcium-permeable channels control intracellular calcium dynamics in both neuronal and nonneuronal cells to orchestrate sensory functions including pain.
Castro-Junior, Célio +4 more
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A first-passage approach to diffusion-influenced reversible binding: insights into nanoscale signaling at the presynapse [PDF]
Sci. Rep. 11, 5377 (2021), 2020 Synaptic transmission between neurons is governed by a cascade of stochastic reaction-diffusion events that lead to calcium-induced vesicle release of neurotransmitter. Since experimental measurements of such systems are challenging due their nanometer and sub-millisecond scale, numerical simulations remain the principal tool for studying calcium ...
arxiv +1 more source
Expression and function of transient receptor potential channels in the female bovine reproductive tract [PDF]
, 2016 © 2016 Elsevier Inc. The epithelium lining the oviduct is critical for early reproductive events, many of which are mediated via intracellular calcium ions.
Atkin, Stephen L. +3 more
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Targeting Calcium-Mediated Inter-Organellar Crosstalk in Cardiac Diseases [PDF]
, 2022 INTRODUCTION: Abnormal calcium signaling between organelles such as the sarcoplasmic reticulum (SR), mitochondria and lysosomes is a key feature of heart diseases.
Hulsurkar, Mohit M +4 more
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Vacuolar calcium channels [PDF]
Journal of Experimental Botany, 2007 The central vacuole is the largest Ca2+ store in a mature plant cell. Ca2+ release from this store contributes to Ca2+-mediated intracellular signalling in a variety of physiological responses. However, the routes for vacuolar Ca2+ release are not well characterized.
Gerald Schönknecht, Igor Pottosin
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Tonic activation of extrasynaptic NMDA receptors decreases intrinsic excitability and promotes bistability in a model of neuronal activity [PDF]
Int J Mol Sci. 2019 Dec 27;21(1). pii: E206, 2018 NMDA receptors (NMDA-R) typically contribute to excitatory synaptic transmission in the central nervous system. While calcium influx through NMDA-R plays a critical role in synaptic plasticity, experimental evidence indicates that NMDAR-mediated calcium influx also modifies neuronal excitability through the activation of calcium-activated potassium ...
arxiv +1 more source
TRP channels in microglia: role in physiology and disease
Frontiers in Cellular Neuroscience, 2015 Microglia are responsible for modulating the cellular environment in the nervous system, where they have neuroprotective effects. In these cells has been reported the expression of different ion channels, including those belonging to the transient ...
Yolima P Torres
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Inhibition of synaptic transmission and G protein modulation by synthetic CaV2.2 Ca2+ channel peptides [PDF]
, 2011 : Modulation of presynaptic voltage-dependent Ca+ channels is a major means of controlling neurotransmitter release. The CaV 2.2 Ca2+ channel subunit contains several inhibitory interaction sites for Gβγ subunits, including the amino terminal (NT) and I ...
Agler +53 more
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Host Calcium Channels and Pumps in Viral Infections
Cells, 2019 Ca2+ is essential for virus entry, viral gene replication, virion maturation, and release. The alteration of host cells Ca2+ homeostasis is one of the strategies that viruses use to modulate host cells signal transduction mechanisms in their favor.
Xingjuan Chen, Ruiyuan Cao, Wu Zhong
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