Results 41 to 50 of about 3,686,002 (351)
T-type calcium channel: a privileged gate for calcium entry and control of adrenal steroidogenesis
Frontiers in Endocrinology, 2016 Intracellular calcium plays a crucial role in modulating a variety of functions such as muscle contraction, hormone secretion, gene expression or cell growth. Calcium signaling has been however shown to be more complex than initially thought.
Michel Florian Rossier +1 more
doaj +1 more source
Low voltage activation of KCa1.1 current by Cav3-KCa1.1 complexes. [PDF]
PLoS ONE, 2013 Calcium-activated potassium channels of the KCa1.1 class are known to regulate repolarization of action potential discharge through a molecular association with high voltage-activated calcium channels.
Renata Rehak +5 more
doaj +1 more source
Store-operated calcium channels in skin
Frontiers in Physiology, 2022 The skin is a complex organ that acts as a protective layer against the external environment. It protects the internal tissues from harmful agents, dehydration, ultraviolet radiation and physical injury as well as conferring thermoregulatory control ...
Declan Manning +3 more
doaj +1 more source
Nature Communications, 2016 Mounting in vitro, in vivo and clinical evidence suggest an important role for filopodia in driving cancer cell invasion. Using a high-throughput microscopic-based drug screen, we identify FDA-approved calcium channel blockers (CCBs) as potent inhibitors
Guillaume Jacquemet +10 more
semanticscholar +1 more source
Pflügers Archiv - European Journal of Physiology, 2018 Tuned calcium entry through voltage-gated calcium channels is a key requirement for many cellular functions. This is ensured by channel gates which open during membrane depolarizations and seal the pore at rest. The gating process is determined by distinct sub-processes: movement of voltage-sensing domains (charged S4 segments) as well as opening and ...
Hering, S. +5 more
openaire +2 more sources
Suramin-Induced Neurotoxicity: Preclinical Models and Neuroprotective Strategies
Molecules, 2018 Suramin is a trypan blue analogon originally developed to treat protozoan infections, which was found to have diverse antitumor effects. One of the most severe side effects in clinical trials was the development of a peripheral sensory-motor ...
David von der Ahe +5 more
doaj +1 more source
The regulation role of calcium channels in mammalian sperm function: a narrative review with a focus on humans and mice [PDF]
PeerJMammalian sperm are characterized as specialized cells, as their transcriptional and translational processes are largely inactive. Emerging researches indicate that Ca2+ serves as a crucial second messenger in the modulation of various sperm ...
Yebin Yang +6 more
doaj +2 more sources
Medicine, 2003 Overdose of calcium channel blockers is potentially lethal. Verapamil and diltiazem are much more dangerous than dihydropyridines. Hypotension with (verapamil and diltiazem) or without (dihydropyridines) heart block and bradycardia are the most important features.
Buckley, Nicholas +2 more
openaire +2 more sources
The involvement of actin, calcium channels and exocytosis proteins in somato-dendritic oxytocin and vasopressin release [PDF]
, 2012 Hypothalamic magnocellular neurons release vasopressin and oxytocin not only from their axon terminals into the blood, but also from their somata and dendrites into the extracellular space of the brain, and this can be regulated independently ...
Tobin, Vicky +8 more
core +1 more source
, 2022 This chapter focuses on calcium movements and their impact on exocytosis in adrenal medullary chromaffin cells (CCs). Upon depolarization, Ca2+ enters the cell through open plasmalemmal voltage-dependent calcium channels (Cav channels) driven by a large ...
García García, Antonio +4 more
core +1 more source