Results 21 to 30 of about 3,686,002 (351)

Regulation of Presynaptic Calcium Channels by Synaptic Proteins

Journal of Pharmacological Sciences, 2003
Calcium entry into nerve termini via voltage gated calcium channels is an essential step in neurotransmission. Consequently, second messenger regulation of calcium channel activity modulates synaptic activity.
Gerald W. Zamponi
doaj   +1 more source

The involvement of TRP channels in bone homeostasis

Frontiers in Endocrinology, 2012
Calcium and bone homeostasis are intimately related. On the one hand, bone relies on a sufficient supply of calcium to maintain its structural and mechanical properties and thus largely depends on calcium absorption in the intestine and calcium ...
Liesbet eLieben, Geert eCarmeliet
doaj   +1 more source

Imaging large cohorts of single ion channels and their activity [PDF]

, 2013
As calcium is the most important signaling molecule in neurons and secretory cells, amongst many other cell types, it follows that an understanding of calcium channels and their regulation of exocytosis is of vital importance.
Euan R. Brown, Katia eHiersemenzel, Brown, Euan R; id_orcid, Katia Hiersemenzel, Rory R. Duncan, Duncan, Rory R, Hiersemenzel, Katia, Rory R Duncan, Euan R Brown   +8 more
core   +1 more source

Presynaptic calcium channels [PDF]

Neuroscience Research, 2018
Presynaptic Ca2+ entry occurs through voltage-gated Ca2+ (CaV) channels which are activated by membrane depolarization. Depolarization accompanies neuronal firing and elevation of Ca2+ triggers neurotransmitter release from synaptic vesicles. For synchronization of efficient neurotransmitter release, synaptic vesicles are targeted by presynaptic Ca2 ...
openaire   +3 more sources

Junctate is a key element in calcium entry induced by activation of InsP3 receptors and/or calcium store depletion [PDF]

, 2004
In many cell types agonist-receptor activation leads to a rapid and transient release of Ca(2+) from intracellular stores via activation of inositol 1,4,5 trisphosphate (InsP(3)) receptors (InsP(3)Rs).
Arnoult, Christophe, Cristiano Grasso, Treves, Susan, Ronjat, Michel, Mikoshiba, Katsuhiko, ARNOULT C, GRASSO C, TREVES, Susan Nella, Ducreux, Sylvie, DUCREUX S, Smida-Rezgui, Sophia, Franzini-Armstrong, Clara, MIKOSHIBA K, SCHRUM A, Sylvie Ducreux, Susan Treves, RONJAT M, Grasso, Cristiano, Zhu, Michael X., Zorzato, Francesco, SMIDA REZGUI S, Sophia Smida-Rezgui, MOCCAGATTA L, Zhu, Michael, Francesco Zorzato, Clara Franzini-Armstrong, Christophe Arnoult, Luca Moccagatta, Schrum, Adam, Michel Ronjat, ZHU MX, GIRARD T, Girard, Thierry, Katsuhiko Mikoshiba, Thierry Girard, FRANZINI ARMSTRONG C, Moccagatta, Luca, Michael X. Zhu, Adam Schrum   +38 more
core   +1 more source

Ion Channels of Pituitary Gonadotrophs and Their Roles in Signaling and Secretion

Frontiers in Endocrinology, 2017
Gonadotrophs are basophilic cells of the anterior pituitary gland specialized to secrete gonadotropins in response to elevation in intracellular calcium concentration.
Stanko S. Stojilkovic, Ivana Bjelobaba, Hana Zemkova   +2 more
doaj   +1 more source

Modulation of Calcium Transients in Cardiomyocytes by Transient Receptor Potential Canonical 6 Channels

Frontiers in Physiology, 2020
Transient receptor potential canonical 6 (TRPC6) channels are non-selective cation channels that are thought to underlie mechano-modulation of calcium signaling in cardiomyocytes.
Azmi A. Ahmad, Azmi A. Ahmad, Molly E. Streiff, Molly E. Streiff, Chris Hunter, Frank B. Sachse, Frank B. Sachse   +6 more
doaj   +1 more source

Functional implications of calcium permeability of the channel formed by pannexin 1. [PDF]

, 2006
Although human pannexins (PanX) are homologous to gap junction molecules, their physiological function in vertebrates remains poorly understood. Our results demonstrate that overexpression of PanX1 results in the formation of Ca(2+)-permeable gap ...
Ivanov, Dmitry, V, Panchin, YV, Vanden Abeele, F, Fabien Vanden Abeele, Panchin, Yuri V, Gordienko, D, Yuri V. Panchin, Baranova, AV, Skryma, R, Baranova, Ancha, V, Skryma, Roman, Gordienko, Dmitri, Gabriel Bidaux, Beck, Benjamin, Ivanov, DV, Prevarskaya, N, Ancha V. Baranova, Baranova, Ancha V, Natalia Prevarskaya, Benjamin Beck, Ivanov, Dmitry V, Panchin, Yuri, Ivanov, Dimitri, Prevarskaya, Natalia, Vanden Abeele, Fabien, Bidaux, G, Bidaux, Gabriel, Dmitry V. Ivanov, Beck, B, Panchin, Yuri, V, Roman Skryma, Dmitri Gordienko   +31 more
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Cav3.2 calcium channel interactions with the epithelial sodium channel ENaC

Molecular Brain, 2019
This study describes the functional interaction between Cav3.2 calcium channels and the Epithelial Sodium Channel (ENaC). β-ENaC subunits showed overlapping expression with endogenous Cav3.2 calcium channels in the thalamus and hypothalamus as detected ...
Agustin Garcia-Caballero, Maria A. Gandini, Shuo Huang, Lina Chen, Ivana A. Souza, Yan L. Dang, M. Jackson Stutts, Gerald W. Zamponi   +7 more
doaj   +1 more source

Gating and calcium-sensing mechanisms of TRPA1 channels revealed. Commentary on “Irritant-evoked activation and calcium modulation of the TRPA1 receptor”

Cell Calcium, 2020
Novel structures of the human TRPA1 channel were determined in the presence of the agonist iodoacetamide and the antagonist A-967079, to reveal the open and closed states of the channel, respectively.
Sebastián E. Brauchi, Brad S. Rothberg
semanticscholar   +1 more source