Results 51 to 60 of about 3,686,002 (351)
Cavβ surface charged residues contribute to the regulation of neuronal calcium channels
Molecular Brain, 2022 Voltage-gated calcium channels are essential regulators of brain function where they support depolarization-induced calcium entry into neurons. They consist of a pore-forming subunit (Cavα1) that requires co-assembly with ancillary subunits to ensure ...
Alexandra Tran-Van-Minh +2 more
doaj +1 more source
The Functions of Store-operated Calcium Channels
Biochimica et biophysica acta. Molecular cell research, 2016 Store-operated calcium channels provide calcium signals to the cytoplasm of a wide variety of cell types. The basic components of this signaling mechanism include a mechanism for discharging Ca2+ stores (commonly but not exclusively phospholipase C and ...
J. Putney +7 more
semanticscholar +1 more source
Nature Communications, 2022 Ultrasonic neuromodulation has the unique potential to provide non-invasive control of neural activity in deep brain regions with high spatial precision and without chemical or genetic modification.
Sangjin Yoo +4 more
semanticscholar +1 more source
TRP channels in microglia: role in physiology and disease
Frontiers in Cellular Neuroscience, 2015 Microglia are responsible for modulating the cellular environment in the nervous system, where they have neuroprotective effects. In these cells has been reported the expression of different ion channels, including those belonging to the transient ...
Yolima P Torres
doaj +1 more source
CaV1 and CaV2 calcium channels mediate the release of distinct pools of synaptic vesicles
eLife, 2023 Activation of voltage-gated calcium channels at presynaptic terminals leads to local increases in calcium and the fusion of synaptic vesicles containing neurotransmitter.
Brian D Mueller +12 more
doaj +1 more source
Lavender oil-potent anxiolytic properties via modulating voltage dependent calcium channels
, 2013 Recent clinical data support the clinical use of oral lavender oil in patients suffering from subsyndromal anxiety. We identified the molecular mechanism of action that will alter the perception of lavender oil as a nonspecific ingredient of aromatherapy
Klugbauer, Norbert +19 more
core +1 more source
Frontiers in Cellular Neuroscience, 2015 Photoreceptors rely upon highly specialized synapses to efficiently transmit signals to multiple postsynaptic targets. Calcium influx in the presynaptic terminal is mediated by voltage-gated calcium channels (VGCC).
Antonella eCaputo +6 more
doaj +1 more source
L-type calcium channels as drug targets in CNS disorders
Channels, 2015 L-type calcium channels are present in most electrically excitable cells and are needed for proper brain, muscle, endocrine and sensory function. There is accumulating evidence for their involvement in brain diseases such as Parkinson disease, febrile ...
Nadine J. Ortner, J. Striessnig
semanticscholar +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Genetic disruption of voltage-gated calcium channels in psychiatric and neurological disorders
Progress in neurobiology, 2015 Highlights • Voltage-gated calcium channel classification—genes and proteins.• Genetic analysis of neuropsychiatric syndromes.• Calcium channel genes identified from GWA studies of psychiatric disorders.• Rare mutations in calcium channel genes in ...
S. Heyes +6 more
semanticscholar +1 more source