Results 81 to 90 of about 315,989 (337)

Weft, Warp & Weave: The Intricate Tapestry of Calcium Channels Regulating T Lymphocyte Function

Frontiers in Immunology, 2013
Calcium (Ca2+) is a universal second messenger important for T lymphocyte homeostasis, activation, proliferation, differentiation and apoptosis. The events surrounding Ca2+ mobilization in lymphocytes are tightly regulated and involve the coordination of
Kyla D Omilusik, Lilian L Nohara, Shawna eStanwood, Wilfred eJefferies   +3 more
doaj   +1 more source

The PTTG1/VASP axis promotes oral squamous cell carcinoma metastasis by modulating focal adhesion and actin filaments

Molecular Oncology, EarlyView.
VASP was found to be overexpressed in metastatic oral squamous cell carcinoma (OSCC) tissues. Notably, PTTG1‐ and VASP‐deficient OSCC cells demonstrated suppressed metastatic properties by disrupting the interaction between the cytoskeleton and focal adhesion (FAs) in the filopodia region.
Suyeon Park, Sang Shin Lee, Shihyun Kim, Yeonjun Lee, Gyeonwon Park, Jung Oh Kim, Jongho Choi   +6 more
wiley   +1 more source

Tweeters and Woofers: The Complex Orchestra of Calcium Currents in T Lymphocytes

Frontiers in Immunology, 2015
Elevation of intracellular calcium ion (Ca2+) levels is a vital event that regulates T lymphocyte homeostasis, activation, proliferation, differentiation, and apoptosis.
Lilian L Nohara, Lilian L Nohara, Shawna R Stanwood, Shawna R Stanwood, Kyla D Omilusik, Kyla D Omilusik, Kyla D Omilusik, Wilfred A Jefferies, Wilfred A Jefferies, Wilfred A Jefferies, Wilfred A Jefferies, Wilfred A Jefferies, Wilfred A Jefferies   +12 more
doaj   +1 more source

Aging Alters the Formation and Functionality of Signaling Microdomains Between L-type Calcium Channels and β2-Adrenergic Receptors in Cardiac Pacemaker Cells

Frontiers in Physiology, 2022
Heart rate is accelerated to match physiological demands through the action of noradrenaline on the cardiac pacemaker. Noradrenaline is released from sympathetic terminals and activates β1-and β2-adrenergic receptors (ΑRs) located at the plasma membrane ...
Sabrina Choi, Oscar Vivas, Matthias Baudot, Claudia M. Moreno   +3 more
doaj   +1 more source

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

Molecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy, Heather Fairfield, Victoria E. DeMambro, Samaa Fadel, Carlos A. Gartner, Michelle Karam, Christian Potts, Princess Rodriguez, Ya‐Wei Qiang, Habib Hamidi, Xiangnan Guan, Calvin P. H. Vary, Michaela R. Reagan   +12 more
wiley   +1 more source

TRPM4 contributes to cell death in prostate cancer tumor spheroids, and to extravasation and metastasis in a zebrafish xenograft model system

Molecular Oncology, EarlyView.
Transient receptor potential melastatin‐4 (TRPM4) is overexpressed in prostate cancer (PCa). Knockout of TRPM4 resulted in reduced PCa tumor spheroid size and decreased PCa tumor spheroid outgrowth. In addition, lack of TRPM4 increased cell death in PCa tumor spheroids.
Florian Bochen, Saurav Subedi, Federico La Manna, Sofia Jarrin, Irida Papapostolou, Marianna Kruithof‐de Julio, Christine Peinelt   +6 more
wiley   +1 more source

Theory and experiment reveal unexpected calcium profiles in one-dimensional systems [PDF]

arXiv, 2013
Calcium is an ubiquitous second messenger that triggers a plethora of key physiological responses. The events are initiated in micro- or nano-sized compartments and determined by the complex interactions with calcium-binding proteins and mechanisms of calcium clearance. Local calcium increases in the vicinity of single channels represent an essentially
arxiv  

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source

Cloning and in silico investigation of a putative voltage-gated calcium channel gene and protein in Astacus leptodactylus

Türk Biyokimya Dergisi, 2023
Voltage-gated calcium channels are essential elements in development of many cellular processes like electrical signaling, contraction secretion and gene expression.
Saglam Berk, Ergin Bora, Beyatli Nazlı Coskun, Arslan Kaan, Bastug Turgut, Purali Nuhan   +5 more
doaj   +1 more source

Mitochondrial calcium channels

FEBS Letters, 2010
Mitochondrial Ca2+handling plays an important role in energy production and various cellular signaling processes. Mitochondrial Ca2+uptake is regulated by the mitochondrial Ca2+uniporter (MCU), at least one non‐MCU Ca2+channel and possibly a mitochondrial ryanodine receptor. Two distinct mechanisms mediate Ca2+outward transport, the Na+‐dependent (mNCX)
openaire   +3 more sources