Results 81 to 90 of about 595,184 (334)

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

New AMD3100 derivatives for CXCR4 chemokine receptor targeted molecular imaging studies: synthesis, anti-HIV-1 evaluation and binding affinities [PDF]

, 2015
CXCR4 is a target of growing interest for the development of new therapeutic drugs and imaging agents as its role in multiple disease states has been demonstrated.
Archibald, Stephen J., Boschetti, Frederic, Boschetti, Frédéric, Cawthorne, Christopher, D'huys, Thomas, Denat, Franck, Desogere, Pauline, Désogère, Pauline, Désogère, Pauline, D‘huys, Thomas, Goze, Christine, Maecke, Helmut R., Maëcke, Helmut R., Poty, Sophie, Schols, Dominique   +14 more
core   +1 more source

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Calcium electroporation in three cell lines: a comparison of bleomycin and calcium, calcium compounds, and pulsing conditions [PDF]

Biochimica et Biophysica Acta (BBA) - General Subjects, 2014
Electroporation with calcium (calcium electroporation) can induce ATP depletion-associated cellular death. In the clinical setting, the cytotoxic drug bleomycin is currently used with electroporation (electrochemotherapy) for palliative treatment of tumors.
Stine Krog Frandsen, Hanne Gissel, Pernille Hojman, Jens Eriksen, Julie Gehl   +4 more
openaire   +4 more sources

Clinically relevant enhancement of human sperm motility using compounds with reported phosphodiesterase inhibitor activity [PDF]

, 2014
STUDY QUESTION: Can we identify compound(s) with reported phosphodiesterase inhibitor (PDEI) activity that could be added to human spermatozoa in vitro to enhance their motility without compromising other sperm functions?
Alasmari, Alasmari, Baker, Barratt, Baxendale, Bjorndahl, Christopher L.R. Barratt, Comhaire, Conti, Cooper, David, Fisch, Ford, Francis, Glenn, Harrison, HFEA, Horvath, Houslay, Huacuja, Hull, Hunnicutt, Irvine, Ivic, Lefièvre, Lefièvre, Lefièvre, Linda Lefièvre, Lorna Frame, Martin, Mortimer, Mrsny, Nassar, Negri, O'Connell, Oladipo A. Madamidola, Paul G. Wyatt, Publicover, Richter, Sarah J. Martins Da Silva, Sean G. Brown, Sousa, Steve Tardif, Stone, Tesarik, Tomlinson, Tomlinson, Torres-Flores, Tournaye, Tournaye, Van der Steeg, Wang, Yang, Yovich, Yovich   +54 more
core   +5 more sources

CO₂ Adsorption Reactions of Synthetic Calcium Aluminum Ferrite (CAF)

Applied Sciences, 2022
In this study, we investigated a mechanism of carbonation reaction by CO2 capture through synthesis of ternary (CaO-Al2O3-Fe2O3) compounds. As for the composition of the sintered calcium aluminum ferrite (SCAF), the proportions of CF-based product and CA-
Woong-Geol Lee, Myong-Shin Song
doaj   +1 more source

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source

Phosphorus Immobilization in Poultry Litter and Litter-amended soils with Aluminum, Calcium and Iron amendments [PDF]

, 1994
Arkansas produces approximately one billion broilers each year. Phosphorous (P) runoff from fields receiving poultry litter is believed to be one of the primary factors affecting water quality in Northwest Arkansas.
Daniels, T. C., Miller, D. M., Moore, P. A., Jr.   +2 more
core   +2 more sources

First Principles NMR Study of Fluorapatite under Pressure

, 2012
NMR is the technique of election to probe the local properties of materials. Herein we present the results of density functional theory (DFT) \textit{ab initio} calculations of the NMR parameters for fluorapatite (FAp), a calcium orthophosphate mineral ...
Astala, Barbara Pavan, Bengtsson, Braun, Calderin, Chappell, Charpentier, Cheeseman, Comodi, Comodi, Davide Ceresoli, De Leeuw, De Leeuw, Ditchfield, Dorozhkin, Dupree, Gervais, Giannozzi, Harris, Harris, Keith, Kutzelnigg, Laurencin, Le Roux, LeGeros, Liang, Lin, Louis-Achille, Mackenzie, Marco Fornari, Mary M.J. Tecklenburg, Mason, Matsos, Matsukage, Mauri, Momma, Parr, Peeters, Perdew, Peroos, Pickard, Pourpoint, Profeta, Raghavan, Rakovan, Rosin-Grget, Rulis, Sahai, Sardar, Schindler, Shannon, Sudarsan, Tamm, Tribble, Wang, Wellman, Wentzcovitch, Williams, Wong, Wu, Xu, Zahn, Zheng   +62 more
core   +1 more source

Influence of Organo-Sulfur Compounds with Overbased Calcium Compounds on Lubrication in Cold Forming

Lubricants, 2017
The authors analyzed the structures of sulfurized olefins using NMR spectroscopy and studied the effects of sulfur chain length and alkyl structure on the ironing performance.
Tomohiro Takaki, Kazuhiro Yagishita, Teppei Tsujimoto, Toshiaki Wakabayashi   +3 more
doaj   +1 more source