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Journal of Neuroscience, 2021 Calcium imaging using GCaMP indicators and miniature microscopes has been used to image cellular populations during long timescales and in different task phases, as well as to determine neuronal circuit topology and organization. Because the hippocampus (
Hannah S Wirtshafter, J. Disterhoft
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Imaging Calcium in Neurons [PDF]
Neuron, 2012 Calcium ions generate versatile intracellular signals that control key functions in all types of neurons. Imaging calcium in neurons is particularly important because calcium signals exert their highly specific functions in well-defined cellular subcompartments. In this Primer, we briefly review the general mechanisms of neuronal calcium signaling.
Grienberger, Christine, Konnerth, Arthur
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From calcium imaging to graph topology
Harvard Data Science Review, 2022 Abstract Systems neuroscience is facing an ever-growing mountain of data. Recent advances in protein engineering and microscopy have together led to a paradigm shift in neuroscience; using fluorescence, we can now image the activity of every neuron through the whole brain of behaving animals.
Ann S. Blevins +3 more
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In Vivo Calcium Imaging of CA3 Pyramidal Neuron Populations in Adult Mouse Hippocampus
eNeuro, 2021 Neuronal population activity in the hippocampal CA3 subfield is implicated in cognitive brain functions such as memory processing and spatial navigation.
Gwendolin Schoenfeld +4 more
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Mesoscale calcium imaging in vivo: evolution and contribution to developmental neuroscience
Frontiers in Neuroscience, 2023 Calcium imaging is commonly used to visualize neural activity in vivo. In particular, mesoscale calcium imaging provides large fields of view, allowing for the simultaneous interrogation of neuron ensembles across the neuraxis.
Teresa Guillamón-Vivancos +4 more
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Calcium Imaging Perspectives in Plants [PDF]
International Journal of Molecular Sciences, 2014 The calcium ion (Ca2+) is a versatile intracellular messenger. It provides dynamic regulation of a vast array of gene transcriptions, protein kinases, transcription factors and other complex downstream signaling cascades. For the past six decades, intracellular Ca2+ concentration has been significantly studied and still many studies are under way.
Kanchiswamy C. M. +3 more
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Quantitative analysis of 1300-nm three-photon calcium imaging in the mouse brain
eLife, 2020 1300 nm three-photon calcium imaging has emerged as a useful technique to allow calcium imaging in deep brain regions. Application to large-scale neural activity imaging entails a careful balance between recording fidelity and perturbation to the sample.
Tianyu Wang +8 more
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Dendritic calcium signals in rhesus macaque motor cortex drive an optical brain-computer interface
Nature Communications, 2021 Surface two-photon imaging of the brain cannot access somatic calcium signals of neurons from deep layers of the macaque cortex. Here, the authors present an implant and imaging system for chronic motion-stabilized two-photon imaging of dendritic calcium
Eric M. Trautmann +20 more
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Real-Time Neuron Detection and Neural Signal Extraction Platform for Miniature Calcium Imaging
Frontiers in Computational Neuroscience, 2020 Real-time neuron detection and neural activity extraction are critical components of real-time neural decoding. In this paper, we propose a novel real-time neuron detection and activity extraction system using a dataflow framework to provide real-time ...
Yaesop Lee +8 more
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CaImAn an open source tool for scalable calcium imaging data analysis
eLife, 2019 Advances in fluorescence microscopy enable monitoring larger brain areas in-vivo with finer time resolution. The resulting data rates require reproducible analysis pipelines that are reliable, fully automated, and scalable to datasets generated over the ...
Andrea Giovannucci +13 more
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