Results 91 to 100 of about 1,747,741 (337)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Metalurgija, 2013 This study aims to produce apatite structures, such as hydroxyapatite (HA) and fluorapatite (FA), from precursor calcium phosphates of biological origin, namely from sea urchin, with mechano-chemical stirring and hot-plating conversion method.
R. Samur +7 more
doaj
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Change of a phosphatic condition of soils at application of high doses of organic fertilizers
RUDN Journal of Agronomy and Animal Industries, 2011 It was established, that entering of high doses of manures into various types of soils leads to increase of maintenance and mobility of phosphates in soils. The effect of influence of high doses of manures on mobility of phosphates in soils is defined by
V A Sedych +4 more
doaj
Materials Research ExpressCalcium phosphates modified with trace elements (sodium, magnesium) and borate-anions as well as composites based on them with different amount of ZrO _2 (5, 10 or 25wt%) were synthesized from aqueous solution with further heating to 600 °C.
N Strutynska +4 more
doaj +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Cements of doped calcium phosphates for bone implantation
, 2009 Doutoramento em Ciência e Engenharia de MateriaisO principal objectivo deste estudo foi o desenvolvimento de cimentos à base de fosfatos de cálcio dopados com Mg, Sr e Zn, para aplicações clínicas.
Pina, Sandra Cristina de Almeida
core
Phosphorus removal in passive treatment technologies for tertiary wastewater treatment [PDF]
, 2014 The treatment of phosphorus at small sewage works requires alternative approaches to the traditional chemical precipitation and biological removal pathways, as such approaches do not align well to the requirements at such a scale in relation to the use
Letshwenyo, Moatlhodi Wise
core
Optimization of struvite precipitation in synthetic biologically treated swine wastewater - Determination of the optimal process parameters [PDF]
, 2013 A sustainable way to recover phosphorus (P) in swine wastewater involves a preliminary step of P dissolution followed by the separation of particulate organic matter.
Daumer, Marie-Line +4 more
core +1 more source