Results 81 to 90 of about 100,161 (306)

Collagen-calcium phosphate composites

Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 1998
There is a widespread clinical need for bone augmentation and replacement. The major solid phases of bone are collagen and calcium phosphate and a bone analogue based on these two constituents should have some useful properties. In this review this theme is developed and the properties of natural and naturally based composites are compared. Composites
Lawson, A, Czernuszka, J
openaire   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Features of the exchange of electrolytes and nitrogenous metabolites under different options of uric acid exchange in healthy female rats

Journal of Education, Health and Sport, 2020
Background. We previously identified 4 variants-clusters of uricemia and uricosuria both in rats and in humans. It was shown that the clusters differ from each other in the constellation of immune, autonomic and endocrine parameters, which correlate ...
Agnieszka Kopystecka, Anatoliy Gozhenko, Inna Korda, Nataliya Badiuk, Walery Zukow, Igor Popovych   +5 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Calcium binding to a remote site can replace magnesium as cofactor for mitochondrial Hsp90 (TRAP1) ATPase activity. [PDF]

, 2018
The Hsp90 molecular chaperones are ATP-dependent enzymes that maintain protein homeostasis and regulate many essential cellular processes. Higher eukaryotes have organelle-specific Hsp90 paralogs that are adapted to each subcellular environment.
Agard, David A, Elnatan, Daniel
core  

Separation and recovery of materials from scrap printed circuit boards [PDF]

, 2007
Printed circuit boards from waste computers, televisions, and mobile phones were pyrolysed in a fixed bed reactor with the aim of separating and recovering the organic and metallic materials.
Balabanovich, Balabanovich, Balabanovich, Barontini, Barontini, Barontini, Barontini, Bhaskar, Blazso, Blazso, Bradna, Brebu, Chien, Cui, Cunliffe, Fisk, Fukushima, Goosey, Hall, Jawitz, Kaminsky, Lassen, Lee, Lee, Luda, Luda, Marsanich, Murphy, Paul T. Williams, Rajput, Shimasaki, Sivalingam, Vainiotalo, Whelan, William J. Hall, Williams, Williamson   +36 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Three-Dimensional Bioprinting Materials with Potential Application in Preprosthetic Surgery [PDF]

, 2016
Current methods in handling maxillofacial defects are not robust and are highly dependent on the surgeon’s skills and the inherent potential in the patients’ bodies for regenerating lost tissues.
Fahmy, Mina D., Jazayeri, Hossein E., Masri, Radi, Razavi, Mehdi, Tayebi, Lobat   +4 more
core   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Focus ion beam/scanning electron microscopy characterization of osteoclastic resorption of calcium phosphate substrates [PDF]

, 2017
This article presents the application of dual focused ion beam/scanning electron microscopy (FIB-SEM) imaging for preclinical testing of calcium phosphates with osteoclast precursor cells and how this high-resolution imaging technique is able to reveal ...
Baldini, Nicola, Ciapetti, Gabriela, Díez Escudero, Anna, Español Pons, Montserrat, Ginebra Molins, Maria Pau, Montufar Jiménez, Edgar Benjamin, Pompo, Gemma di   +6 more
core   +2 more sources