Results 51 to 60 of about 51,274 (254)

Bone without borders – Monetite-based calcium phosphate guides bone formation beyond the skeletal envelope

Bioactive Materials, 2023
Calcium phosphates (CaP) represent an important class of osteoconductive and osteoinductive biomaterials. As proof-of-concept, we show how a multi-component CaP formulation (monetite, beta-tricalcium phosphate, and calcium pyrophosphate) guides ...
Furqan A. Shah, Martina Jolic, Chiara Micheletti, Omar Omar, Birgitta Norlindh, Lena Emanuelsson, Håkan Engqvist, Thomas Engstrand, Anders Palmquist, Peter Thomsen   +9 more
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Micro- and macrostresses in two level model of coating growth [PDF]

, 2005
In the work, a two level model of coating growing with the diffusion and chemical compounds formation is proposed. The process of coating formation includes different physico-chemical steps and transformations of the structure.
Nazarenko, N. N., Knyazeva, Anna Georgievna   +1 more
core   +2 more sources

Bisphosphonate inhibits the expression of cyclin A2 at the transcriptional level in normal human oral keratinocytes. [PDF]

, 2017
Nitrogen-containing bisphosphonates (N-BPs) are the most widely used anti-resorptive agents in the treatment of bone-related diseases. N-BPs inhibit bone resorption by specifically targeting osteoclasts, bone-resorbing cells.
Kang, Mo K, Kim, Reuben H, Lee, Rachel S, Park, No-Hee, Shin, Ki-Hyuk, Sohn, Suhjin   +5 more
core   +1 more source

Farnesyltransferase Deficiency in Cardiomyocytes Initiates Senescence and Contributes to Cardiac Fibrosis

Advanced Science, EarlyView.
Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen, Lian Lou, Xuan Zhang, Lin Yan, Qi Zhang, Wen Shi, Jie Ding, Xu Lin, Rong Jiang, Shuo Liu, Thida Sok, Pengli Wang, Yun Mou, Jie Han, Shenjiang Hu, Xiaogang Guo, Jian Yang   +16 more
wiley   +1 more source

Supra and subgingival application of antiseptics or antibiotics during periodontal therapy

Periodontology 2000, EarlyView., 2023
Abstract Periodontal diseases (gingivitis and periodontitis) are characterized by inflammatory processes which arise as a result of disruption of the balance in the oral ecosystem. According to the current S3 level clinical practice guidelines, therapy of patients with periodontitis involves a stepwise approach that includes the control of the patient ...
Elena Figuero, Jorge Serrano, Nicole Birgit Arweiler, Thorsten Mathias Auschill, Ali Gürkan, Gülnur Emingil   +5 more
wiley   +1 more source

A BioLiving Periosteum Evokes Centripetal Regeneration in Challenging Bone Defects

Advanced Science, EarlyView.
Large bone defects often suffer from insufficient central healing. This study engineers a BioLiving periosteum that mimics the native structure. It sequentially delivers remote chemical cues and contact physical cues in a signaling‐relay manner, effectively recruiting and guiding endogenous cells toward the defect center.
Yang Shi, Nian Liu, Jingyi Gu, Yinling Wang, Weiye Wang, Zhiwei Ke, Mingjun Xie, Wenjing Jin, Weicheng Kong, Jue Shi, Hui Pan, Yong He, Zhijian Xie   +12 more
wiley   +1 more source

Chondrogenesis in the synovial tissue is associated with the onset of pseudogout after total knee arthroplasty

Arthroplasty Today, 2016
Postoperative pseudogout after total knee arthroplasty (TKA) is very rare, and its physical findings are very similar to infectious symptoms. In pseudogout, the mechanism underlying the deposition of calcium pyrophosphate dehydrate crystals remains ...
Ryosuke Sato, MD, Shunji Nakano, MD, PhD, Tomoya Takasago, MD, Masaru Nakamura, MD, Masahiro Kashima, MD, Takashi Chikawa, MD, PhD, Daisuke Hamada, MD, PhD, Tomohiro Goto, MD, PhD, Koichi Sairyo, MD, PhD   +8 more
doaj   +1 more source

Mineral maturity and crystallinity index are distinct characteristics of bone mineral [PDF]

, 2010
The purpose of this study was to test the hypothesis that mineral maturity and crystallinity index are two different characteristics of bone mineral. To this end, Fourier transform infrared microspectroscopy (FTIRM) was used.
A Boskey, A Carden, A Carden, A Gee, A Shemesh, AB Barry, AC Ferrari, AL Boskey, AL Boskey, AL Boskey, AS Posner, B Giri, C Jager, C Rey, C Rey, C Rey, C Rey, CH Turner, CH Turner, CH Turner, Christian Rey, CP Tarnowski, D Chachra, D Faibish, Delphine Farlay, E Durchschlag, E Fitzer EG, E Pucéat, EP Paschalis, EP Paschalis, EP Paschalis, EP Paschalis, G Boivin, Georges Boivin, Gérard Panczer, J Green, JD Termine, JS Yerramshetty, JW Ager, KL Dziak, L Nasdala, LM Miller, LM Miller, LM Miller, MD Grynpas, MD Morris, MG Glimcher, N Pleshko, NP Camacho, O Akkus, O Akkus, P Fratzl, P Fratzl, PD Frazier, Pierre D. Delmas, RG Hanschin, RY Huang, RZ Legeros, S Bang, S Bohic, S Cazalbou, S Tadano, SJ Gadaleta, WJ Landis, Y Li   +64 more
core   +3 more sources

Affinity‐Based Interactome Mapping of Inositol Pyrophosphates Reveals 4/6‐PP‐InsP5‐Binding Proteins in Plants

Advanced Science, EarlyView.
ABSTRACT Inositol pyrophosphates (PP‐InsPs) are central regulators of eukaryotic signaling events. While certain PP‐InsP isomers have been conclusively linked to the regulation of phosphate homeostasis through interaction with SPX domain‐containing proteins in plants, the functions of the recently discovered isomer 4/6‐PP‐InsP5 remain largely unknown ...
Kevin Ritter, Verena Gaugler, Sara Christina Stolze, Riya Ghosh, Akhila Jayamon, Ranjana Yadav, Felix Wollensack, Debabrata Laha, Hirofumi Nakagami, Gabriel Schaaf, Henning Jacob Jessen   +10 more
wiley   +1 more source