Results 121 to 130 of about 6,142,205 (404)

Plant Calcium Signaling in Response to Potassium Deficiency

open access: yesInternational Journal of Molecular Sciences, 2018
Potassium (K+) is an essential macronutrient of living cells and is the most abundant cation in the cytosol. K+ plays a role in several physiological processes that support plant growth and development.
Xiaoping Wang   +3 more
semanticscholar   +1 more source

The solution supramolecular structure of α2 → 8 polysialic acid suggests a structural cause for its low immunogenicity

open access: yesFEBS Letters, EarlyView.
α2 → 8 polysialic acid elicits poor immunogenicity. Small‐angle scattering shows a supramolecular structure with parallel‐chain binding, although in different forms at μm and mm calcium. The major histocompatibility complex requires molecular weights around 2000 Da to produce antibodies, and 2000 Da polysialic oligomers will bind in these structures ...
Kenneth A. Rubinson
wiley   +1 more source

MYB30 transcription factor regulates oxidative and heat stress responses through ANNEXIN-mediated cytosolic calcium signaling in Arabidopsis.

open access: yesNew Phytologist, 2017
Cytosolic calcium signaling is critical for regulating downstream responses in plants encountering unfavorable environmental conditions. In a genetic screen for Arabidopsis thaliana mutants defective in stress-induced cytosolic free Ca2+ ([Ca2+ ]cyt ...
Chancan Liao, Yuan Zheng, Yan Guo
semanticscholar   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

Finite element model to study two dimensional unsteady state calcium distribution in cardiac myocytes

open access: yesAlexandria Journal of Medicine, 2016
The calcium signaling plays a crucial role in expansion and contraction of cardiac myocytes. This calcium signaling is achieved by calcium diffusion, buffering mechanisms and influx in cardiac myocytes.
Kunal Pathak, Neeru Adlakha
doaj   +1 more source

Calcium as a cardiovascular toxin in CKD-MBD [PDF]

open access: yes, 2017
Disordered calcium balance and homeostasis are common in patients with chronic kidney disease. Such alterations are commonly associated with abnormal bone remodeling, directly and indirectly.
Moe, Sharon M.
core   +1 more source

Electrodiffusion with calcium-activated potassium channels in dendritic spine [PDF]

open access: yesarXiv, 2019
We investigate calcium signaling feedback through calcium-activated potassium channels of a dendritic spine by applying the immersed boundary method with electrodiffusion. We simulate the stochastic gating of such ion channels and the resulting spatial distribution of concentration, current, and membrane voltage within the dendritic spine.
arxiv  

Correlation in Neuronal Calcium Spiking: Quantification based on Empirical Mutual Information Rate [PDF]

open access: yesarXiv, 2021
Quantification of neuronal correlations in neuron populations helps us to understand neural coding rules. Such quantification could also reveal how neurons encode information in normal and disease conditions like Alzheimer's and Parkinson's. While neurons communicate with each other by transmitting spikes, there would be a change in calcium ...
arxiv  

Dysregulation of Intracellular Calcium Signaling in Alzheimer's Disease.

open access: yesAntioxidants and Redox Signaling, 2018
SIGNIFICANCE Calcium (Ca2+) hypothesis of Alzheimer's disease (AD) gains popularity. It points to new signaling pathways that may underlie AD pathogenesis.
E. Popugaeva   +2 more
semanticscholar   +1 more source

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

open access: yesMolecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever   +1 more
wiley   +1 more source

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