Results 111 to 120 of about 518,632 (310)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Osteocytic network is more responsive in calcium signaling than osteoblastic network under fluid flow

, 2012
Osteocytes, regarded as the mechanical sensor in bone, respond to mechanical stimulation by activating biochemical pathways and mediating the cellular activities of other bone cells.
Guo, XE, Chiang V, Guo XE, Columbia Univ, Dept Biomed Engn, Bone Bioenn Lab, 351 Engn Terrace,Mail Code 8904,1210 Amsterdam Av, New York, NY 10027 USA., Lu XL, Huo B(霍波)   +5 more
core   +1 more source

Fruit Calcium: Transport and Physiology

Frontiers in Plant Science, 2016
Calcium has well-documented roles in plant signaling, water relations and cell wall interactions. Significant research into how calcium impacts these individual processes in various tissues has been carried out; however, the influence of calcium on fruit
Bradleigh eHocking, Stephen Donald Tyerman, Rachel eBurton, Matthew eGilliham   +3 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Gray matter NG2 cells display multiple Ca2+-signaling pathways and highly motile processes

, 2011
NG2 cells, the fourth type of glia in the mammalian CNS, receive synaptic input from neurons. The function of this innervation is unknown yet. Postsynaptic changes in intracellular Ca2+-concentration ([Ca2+]i) might be a possible consequence. We employed
Steinhäuser, Christian, Julia Haseleu, Karram, Khalad, Frotscher, Michael, Alexandra Wyczynski, Christian Haberlandt, Jabs, Ronald, Michael Frotscher, Wyczynski, Alexandra, Trotter, Jacqueline, Seifert, Gerald, Khalad Karram, Jacqueline Trotter, Christian Steinhäuser, Gerald Seifert, Derouiche, Amin, Jörg Pohle, Pohle, Jörg, Haberlandt, Christian, Haseleu, Julia, Ronald Jabs, Amin Derouiche   +21 more
core   +1 more source

Genetically Encoded Calcium Indicators: A New Tool in Renal Hypertension Research

Frontiers in Medicine, 2019
Hypertension is ranked as the third cause of disability-adjusted life-years. The percentage of the population suffering from hypertension will continue to increase over the next years.
Cheng Zhong, Johanna Schleifenbaum
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Characterization of XVEF and XvCaM : two calcium-binding proteins isolated from the resurrection plant Xerophyta viscosa

, 2005
Includes bibliographical references.Xerophyta viscosa (Baker) is a resurrection plant with the ability to survive desiccation and rehydrate upon watering with minimal tissue damage.
Conrad, Nailah
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Calcium channels as therapeutic targets in head and neck squamous cell carcinoma: current evidence and clinical trials

Frontiers in Oncology
Head and neck squamous cell carcinoma (HNSCC) originates from the mucosal epithelium of the oral cavity, pharynx, and larynx, and is marked by high rates of recurrence and metastasis.
Jinye Lin, Xijia Wang, Shibo Ma, Dunhui Yang, Kang Li, Dongcai Li, Xianhai Zeng   +6 more
doaj   +1 more source