Results 121 to 130 of about 1,856,966 (308)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Role of Calcium Signaling in the Pathogenesis of Neurodegenerative Diseases

Acta Medica Bulgarica
Calcium (Ca²+) is a central intracellular second messenger regulating cellular homeostasis through tightly controlled signaling. Intracellular Ca²+ dynamics depend on coordinated interactions between the endoplasmic reticulum (ER), mitochondria, and ...
Panayotova D., Kokanova-Nedyalkova Z., Kondeva-Burdina M.   +2 more
doaj   +1 more source

Resveratrol derivatives increase cytosolic calcium by inhibiting plasma membrane ATPase and inducing calcium release from the endoplasmic reticulum in prostate cancer cells

Biochemistry and Biophysics Reports, 2019
Resveratrol (RES) is a putative chemotherapeutic naturally found in grapes, peanuts, and Japanese knotweed. Previous studies demonstrate that RES modulates calcium signaling as part of its chemotherapeutic activity.
Joshua A. Peterson, Colton M. Crowther, Merritt B. Andrus, Jason D. Kenealey   +3 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Dendritic calcium accumulation associated with direction-selective adaptation in visual motion-sensitive neurons in vivo [PDF]

, 2000
Kurtz R, Dürr V, Egelhaaf M. Dendritic calcium accumulation associated with direction-selective adaptation in visual motion-sensitive neurons in vivo. Journal of Neurophysiology.
Egelhaaf, Martin ; https://orcid.org/, Rafael Kurtz, Martin Egelhaaf, Martin Egelhaaf Dendritic Calcium, Kurtz, Rafael, Dürr, Volker ; https://orcid.org/, Volker Dürr   +6 more
core   +1 more source

Genetically Encoded Calcium Indicators: A New Tool in Renal Hypertension Research

Frontiers in Medicine, 2019
Hypertension is ranked as the third cause of disability-adjusted life-years. The percentage of the population suffering from hypertension will continue to increase over the next years.
Cheng Zhong, Johanna Schleifenbaum
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling [PDF]

, 2012
Many cellular processes including apoptosis, autophagy, translation, energy metabolism, and inflammation are controlled by the mammalian target of rapamycin (mTOR) kinase and the endoplasmic reticulum (ER) stress pathway, also known as the unfolded ...
Appenzeller-Herzog, Christian, Hall, Michael N.   +1 more
core   +1 more source

Fruit Calcium: Transport and Physiology

Frontiers in Plant Science, 2016
Calcium has well-documented roles in plant signaling, water relations and cell wall interactions. Significant research into how calcium impacts these individual processes in various tissues has been carried out; however, the influence of calcium on fruit
Bradleigh eHocking, Stephen Donald Tyerman, Rachel eBurton, Matthew eGilliham   +3 more
doaj   +1 more source