Results 41 to 50 of about 1,831 (213)

Impacts of Research Staff Burnout for a National Large Scale Pragmatic Clinical Trial

Open Access Journal of Clinical Trials, 2021
Alison Majkut Klint,1 Jacob McPherson,2 Abhinav Tella,2 William Vang,2 Srihari Raju,2 Rebecca Windschitl,2 Areef Ishani3 1Boston CSPCC, VA Boston Healthcare System, Jamaica Plain, MA, USA; 2Research, Minneapolis VAHCS, Minneapolis, MN, USA; 3Primary Care
Majkut Klint A, McPherson J, Tella A, Vang W, Raju S, Windschitl R, Ishani A   +6 more
doaj  

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Seasonal Proteome Variations in Orbicella faveolata Reveal Molecular Thermal Stress Adaptations

Proteomes
Although seasonal water temperatures typically fluctuate by less than 4 °C across most tropical reefs, sustained heat stress with an increase of even 1 °C can alter and destabilize metabolic and physiological coral functions, leading to losses of coral ...
Martha Ricaurte, Nikolaos V. Schizas, Ernesto F. Weil, Pawel Ciborowski, Nawal M. Boukli   +4 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Offshoring de serviços de call center: um estudo comparativo entre Brasil, Índia e África do Sul Offshoring de servicios de call center: un estudio comparativo entre Brasil, India y África del Sur Offshoring of call center services: a comparison of brazilian, indian and south african options

REGE Revista de Gestão, 2009
O setor de call centers tem apresentado grande desenvolvimento em todo o mundo, impulsionado principalmente pelo avanço observado nas telecomunicações e na tecnologia da informação e pela necessidade de oferecer atendimento aos clientes, em muitos casos ...
Paulo Roberto Gião, Moacir de Miranda Oliveira Júnior   +1 more
doaj  

Modelo para segmentação da demanda de um Call Center em múltiplas prioridades: Estudo da implantação em um Call Center de Telecomunicações

Revista Produção Online, 2004
A crescente necessidade de relacionar-se de forma eficiente com seus Clientes levou as empresas à criação de um serviço que permite a sua orientação e captação pelo ...
Marcus Araújo, Francisco Araújo, Paulo Adissi   +2 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Capacitación de personal: Gestión de atención en Call Center de EsSalud

Revista Venezolana de Gerencia, 2018
La investigación buscó demostrar la incidencia del nivel de los cursos de capacitación en las trabajadoras del Call Center de EsSalud en la efectividad del otorgamiento de citas en línea en el departamento de Huancavelica en el Perú; investigación ...
Víctor Hugo Barrientos Ramos, Luis Pablo Díaz Tito, Mildred Jénica Ledesma Cuadros, Edward Filomeno Huamani Alhuay   +3 more
doaj  

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source