Results 91 to 100 of about 77,245 (243)
Tecnociencia, 2021 The protozoan parasite Trypanosoma cruzi is the causative agent of Chagas disease, an endemic illness in Panama. In this parasite, regulation of gene expression is mainly a post transcriptional process.
Luis Jaén +3 more
doaj
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Doxorubicin (DOX) is a highly effective anthracycline, whose clinical application for cancer is limited by cardiotoxicity. The mechanisms underlying doxorubicin‐induced toxic cardiomyopathy (DICM) involve electrophysiological remodelling with intracellular Na+ overload because of increased late INa and hyperactivation of
Anna‐Lena Feder +7 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Background and Purpose In contrast to neurons in the central nervous system, neurons in the peripheral nervous system can regenerate axons after injury via activation of a pro‐regenerative transcriptional programme. Pathogenic mutations in leucine‐rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease, and several small ...
Eun‐Hae Jang +11 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Positive allosteric modulators bind to secondary binding sites on the receptor and alter receptor conformation and activation, changing agonist potency and efficacy. PTC‐174 is a novel NMDA receptor positive allosteric modulator that particularly enhances activity of receptors containing GluN2C or GluN2D subunits.
Bangyuan Liu, Alasdair J. Gibb
wiley +1 more source
The epigenetic landscape of skeletal muscle in response to exercise and aging
The FEBS Journal, EarlyView.Epigenetic mechanisms regulate gene expression in response to exercise and aging, thereby supporting skeletal muscle plasticity. Acute exercise induces chromatin remodeling through histone modifications and DNA methylation, promoting the expression of exercise‐responsive genes.
Sabrina Champsi, David A. Hood
wiley +1 more source
Insect Molecular Biology, EarlyView.Parasitoid wasps deploy maternal and embryonic factors to reprogramme host physiology. Venom, calyx fluid, polydnaviruses, teratocytes and larval secretions act in a coordinated, compartmentalised manner. Host‐regulation factors are promising sources of insecticidal, antimicrobial and bioinspired translational molecules.
Ciro Pedro G. Pinto +2 more
wiley +1 more source
Crop JournalPlant calmodulins (CaMs) and calmodulin-like proteins (CMLs) mediate Ca2+ signaling in response to abiotic stresses. Manipulation of this signaling in crops could increase stress tolerance.
Shuang Liu +6 more
doaj +1 more source
Calmodulin-binding proteins as calpain substrates [PDF]
Biochemical Journal, 1989 K K, Wang, A, Villalobo, B D, Roufogalis
openaire +2 more sources
Myo1g Mediates NKR‐P1C Expression in Primary Mouse NK Cells and Participates in Cytotoxicity
Immunology, EarlyView.In this study we analysed the participation of Myosin 1g in the development and functions of murine natural killer (NK) cells; we found that Myosin 1g is expressed in murine‐activated primary NK cells from the spleen. Additionally, in the absence of Myosin 1g, correlates with a reduced expression of NKR‐P1C but not of CD49b or NKp46.
Héctor Romero‐Ramírez +3 more
wiley +1 more source
G protein βγ regulation of KCNQ-encoded voltage-dependent K channels
Frontiers in PhysiologyThe KCNQ family is comprised of five genes and the expression products form voltage-gated potassium channels (Kv7.1–7.5) that have a major impact upon cellular physiology in many cell types.
Jennifer B. Stott, Iain A. Greenwood
doaj +1 more source