Results 191 to 200 of about 2,710,839 (274)

Mucosal‐Associated Invariant T Cells in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
The roles of MAIT cells in health and disease and their therapeutic applications. In healthy individuals, riboflavin metabolites secreted by commensal bacteria at mucosal sites are presented by MR1, leading to the activation of MAIT cells. Activated MAIT cells can maintain the barrier integrity of mucosal tissues in a steady state or migrate to the ...
Yu Zhao, Feng‐Mi Ou, Dan Liang, Yang Gao, Qing‐Qing Li, Yi‐Qun Kuang   +5 more
wiley   +1 more source

Targeting Plasma Membrane Ca²⁺-ATPases in Cancer: Current Insights and Future Perspectives. [PDF]

Cancers (Basel)
Lisek M, Tomczak J, Bochenska N, Duraj J, Boczek T.   +4 more
europepmc   +1 more source

Machine Learning‐Based Development of Gadolinium Binding Peptides

NMR in Biomedicine, Volume 39, Issue 10, October 2026.
In this study, Dayan et al. employed a machine‐learning‐driven peptide‐evolution platform, the Protein Optimization Engineering Tool (POET), to design and optimize short Gd‐binding motifs to enhance longitudinal relaxivity (r1). ABSTRACT Gadolinium‐based contrast agents (GBCAs) are indispensable tools in magnetic resonance imaging (MRI), yet their ...
Nir A. Dayan, Makayla Long, Nicolas Scalzitti, Iliya Miralavy, Daniel Holmes, Mark Kocherovsky, Wolfgang Banzhaf, Assaf A. Gilad   +7 more
wiley   +1 more source

Data sets on the interaction of FKBP35 from <i>Plasmodium knowlesi</i> and Hsp90 C-terminal pentapeptide. [PDF]

Data Brief
Budiman C, Robert AR, Silvester J, Lee PC, Ahmed K, Leow TC, Padzil AM, Suzery M, Takano K, Prihanto AA.   +9 more
europepmc   +1 more source

Adenylyl cyclase 9 as a molecular scaffold to dissect the mechanisms of membrane adenylyl cyclases

Protein Science, Volume 35, Issue 10, October 2026.
Abstract Adenylyl cyclases (ACs) convert ATP into the second messenger cAMP, thus directly influencing cellular signaling in response to a wide variety of stimuli. Despite their physiological importance, structural studies of isoform‐specific AC regulation are compounded by difficulties in AC expression and purification.
Ilayda Kantarci, Haoriwa Haoriwa, Volodymyr M. Korkhov   +2 more
wiley   +1 more source

An Integrative Approach Toward Bio-Inspired Sequestration of Rare Earth Elements. [PDF]

ChemSusChem
Perevedentseva Y, Waurick L, Marlina D, Techert G, Müllers Y, Lederer F, Möller HM, Kumke MU, Glebe U, Drobot B.   +9 more
europepmc   +1 more source

The Binding of Fibroblast Growth Factor 23 (FGF23) to FGF Receptor‐αKlotho Complex Increases Sinoatrial Electrical Activity

Acta Physiologica, Volume 242, Issue 10, October 2026.
ABSTRACT Aim This study aims to investigate whether the Fibroblast Growth Factor 23 (FGF23) modulates the electrical activity of sinoatrial (SAN) cells. The canonical function of FGF23 is to regulate body phosphorus and calcium homeostasis by activating the FGF1 receptors (FGFR1)/α‐Klotho complex in the kidney and parathyroid glands.
Giorgia Bertoli, Patrizia Benzoni, Serena Canzolino, David Molla, Raffaella Milanesi, Chiara Piantoni, Makoto Kuro‐o, Carmen Delgado, Gema Ruiz‐Hurtado, Mirko Baruscotti, Annalisa Bucchi   +10 more
wiley   +1 more source

Inhibition of leucine‐rich kinase 2 (LRRK2) promotes peripheral axon regeneration via phosphorylation‐network remodelling

British Journal of Pharmacology, Volume 183, Issue 20, Page 6199-6224, October 2026.
Background and Purpose In contrast to neurons in the central nervous system, neurons in the peripheral nervous system can regenerate axons after injury via activation of a pro‐regenerative transcriptional programme. Pathogenic mutations in leucine‐rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease, and several small ...
Eun‐Hae Jang, Eun Mo Yang, Gil Song, Seung Min Park, Harryn Choi, Jaeyong Kim, Chanil Kim, Yunho Gim, Hyuk‐Joo Jeon, Yewon Cho, Jong Bae Park, Eun‐Mi Hur   +11 more
wiley   +1 more source

Machine Learning and Experimental Verification Identify Anti-Influenza Natural Products. [PDF]

Int J Mol Sci
Qiu F, Wu J, Cao Y, Li X, Wang S, Xue K, Wang Y, Bu Y, Shen B, Gao Y.   +9 more
europepmc   +1 more source

Insights Into the Role of Lysine Acetylation of Non‐Histone Proteins in Plant Immunity

Plant, Cell &Environment, Volume 49, Issue 10, Page 7604-7618, October 2026.
ABSTRACT Plant immunity is regulated by numerous transcriptional and posttranslational mechanisms. Among these, lysine acetylation, which is controlled by lysine acetyltransferases (KATs) and lysine deacetylases (KDACs), has been extensively studied, particularly in the context of epigenetic regulation through histone acetylation.
Jérémy Villette, Chloé Ilbert, Sébastien Aimé, Hoai‐Nam Truong, Marielle Adrian, Stéphane Bourque   +5 more
wiley   +1 more source