Results 191 to 200 of about 131,283 (255)

Calcium‐activated chloride channels in pericytes and their role in regulating organ blood flow

The Journal of Physiology, EarlyView.
Abstract figure legend Pericytes are microvascular mural cells with diverse roles. Contractile pericytes directly regulate local perfusion, while non‐contractile pericytes coordinate upstream vascular contractility via propagating electrical signals.
Paolo Tammaro, Hikaru Hashitani
wiley   +1 more source

A Chronic, Solitary Skin Ulcer Owing to Sporotrichosis. [PDF]

Am J Trop Med Hyg
Antunez de Mayolo N, Maguiña-Vargas C, Chincha O.   +2 more
europepmc   +1 more source

Antiestrogens as calmodulin antagonists

Antiestrogens are widely used in the treatment of hormone dependent breast cancer. Their principle mechanism of action is believed to be the displacement of the growth promoting hormone estrogen from its protein receptor.
Rowlands MG, Jarman M, Hardcastle IR
core  

TMEM16A Ca2+‐activated Cl− channel: Functional interactions with cytoskeletal and membrane‐associated proteins

The Journal of Physiology, EarlyView.
Abstract figure legend The calcium‐activated chloride (ClCa) channel TMEM16A (also known as ANO1) plays critical roles in ion transport, neurotransmission and smooth muscle contraction. Dysregulation of TMEM16A channel activity contributes to the development and progression of various diseases.
Hisao Yamamura, Rubii Kondo, Yoshiaki Suzuki, Yuji Imaizumi, Aya Yamamura   +4 more
wiley   +1 more source

Assessment of paralogue annotation for improving diagnostic accuracy in <i>CALM1</i>, <i>CALM2</i>, and <i>CALM3</i> genes. [PDF]

Front Genet
Curry KM, Mujkic A, Syverud N, McGill AK, Beckwell JE, Wiley EA, Bissonnette J, Kurtovic-Kozaric A, Kiel MJ.   +8 more
europepmc   +1 more source

Mechanisms underlying local Ca2+ signalling differences between right and left atrial myocytes at normal and increased frequencies

The Journal of Physiology, EarlyView.
Abstract figure legend Left atrial myocytes have TAT‐associated faster Ca2+ release but are more prone to maladaptation at higher frequencies due to weaker peripheral SR Ca2+ uptake and smaller trigger Ca2+ current. Abstract Changes in heart rate affect Ca2+ signalling and contractility in ventricular muscle, but the effects on atrial Ca2+ signalling ...
Joon‐Chul Kim, Hieu Trong Huynh, Phuong Kim Luong, Tran Nguyet Trinh, Yixuan Wu, Eleonora Grandi, Sun‐Hee Woo   +6 more
wiley   +1 more source

Bioelectric Reawakening by a Self-Powered Thermoelectric Hydrogel Accelerates Diabetic Ulcer Repair. [PDF]

Adv Mater
Luo W, Zhang S, Sun H, Chen X, Lu L, Li N, Li D, Rong Y, Mi B, Qiao Y, Zhu C, Bai J.   +11 more
europepmc   +1 more source

Deciphering pro‐arrhythmogenic mechanisms of EPAC in human atrial cardiomyocytes

The Journal of Physiology, EarlyView.
Abstract figure legend This study aimed to investigate the effect of exchange proteins directly activated by cAMP (EPAC) on the regulation of human atrial cardiomyocyte electrophysiology and their potential involvement in the onset of atrial fibrillation (AF).
Arthur Boileve, Margaux Aize, Maximin Détrait, Laura Brard, Adrien Leboyer, Pierre‐Antoine Dupont, Alexandre Lebrun, Vladimir Saplacan, Christophe Simard, Fabien Brette, Frank Lezoualc'h, Laurent Sallé   +11 more
wiley   +1 more source

From Proteinopathy to Immunopathy in Alzheimer's Disease-A Role for Astrocytic Calcineurin? [PDF]

J Neurochem
Lim D, Tapella L.
europepmc   +1 more source

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca2+ in driving atrial fibrillation‐associated fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani, Haibo Ni, Jeffrey J Saucerman, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +5 more
wiley   +1 more source