Results 181 to 190 of about 122,133 (302)

Energetic microdomains and the vascular control of neuronal and muscle excitability: Toward a unified model

The Journal of Physiology, EarlyView.
Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
wiley   +1 more source

An RNA interference biopesticide reduces reproduction of the honey bee parasite Varroa destructor by down-regulating embryo development pathways. [PDF]

Pest Manag Sci
Smeele ZE, McGruddy RA, Baty JW, Manley B, Narva K, De Neef E, Gordon ER, Devisetty UK, Youngs K, Felden A, Lester PJ.   +10 more
europepmc   +1 more source

Cellular mechanisms of radiation‐induced myocyte dysfunction: effects on calcium handling, ion channel regulation and mitochondrial energetics

The Journal of Physiology, EarlyView.
Abstract figure legend Dose‐dependent effects of radiation on cardiac electrophysiology and arrhythmia susceptibility. At low radiation doses (left), increased reactive oxygen species (ROS) initiate an ROS–Ca2+ positive feedback loop involving calcium/calmodulin‐dependent protein kinase II (CaMKII) activation, enhanced L‐type Ca2+ current (ICaL ...
Hannah M. Zukowski, Colleen E. Clancy
wiley   +1 more source

CaMKII as a Multimodal Signalling Hub in Neural Connectivity and Vulnerability. [PDF]

Mol Neurobiol
Olliff S, Sundaramoorthy V.
europepmc   +1 more source

Potential health benefits of cold‐water immersion: the central role of PGC‐1α

The Journal of Physiology, EarlyView.
Abstract figure legend Cold‐water immersion (CWI) elicits autonomic, somato‐motoric (shivering thermogenesis), endocrine and metabolic, sensory transduction, and local biophysical effects that may converge on the transcriptional co‐activator PGC‐1α (centre).
Erich Hohenauer, Wafa Douzi, Johannes Burtscher   +2 more
wiley   +1 more source

Phenotypic expansion of CALM1/2-associated disorders to include neurologic phenotypes without arrhythmia. [PDF]

Hum Mol Genet
Hoang HD, Spillmann RC, Wegner DJ, Tedesco MG, Brohus M, Novelli A, Stregapede F, Rogaia D, Troiani S, Lesinski J, Yuan W, Fielder SM, Zhang B, Morrison S, Regmi S, Foti MRS, Baldridge D, Silverman GA, Undiagnosed Diseases Network, Shea P, Dickson P, Wambach JA, Overgaard MT, Jensen HH, Olsen A, Prontera P, Shashi V, Pak SC, Schedl T.   +28 more
europepmc   +1 more source

Excessive training does not induce mitochondrial dysfunction or impair insulin signalling within skeletal muscle

The Journal of Physiology, EarlyView.
Abstract figure legend Three weeks of overtraining in trained endurance athletes reduced exercise performance without impairing glucose tolerance. In skeletal muscle, overtraining was associated with increased expression of lipid metabolism‐related proteins, enhanced mitochondrial biogenesis and preserved insulin signalling, despite elevated oxidative ...
Geneviève J. DesOrmeaux, Henver S. Brunetta, Pierre‐Andre Barbeau, Alexandra M. Coates, Christopher Pignanelli, Fasih A. Rahman, Jamie F. Burr, Graham P. Holloway   +7 more
wiley   +1 more source

Effects of electromyostimulation on sarcolipin and Ca²⁺ signaling in rat skeletal muscles. [PDF]

Biochem Biophys Rep
Okumura K, Takegaki J, Sase K, Fukao N, Fujita S.   +4 more
europepmc   +1 more source

Small‐conductance Ca2⁺‐activated K⁺ channels in cardiac excitation–contraction coupling: Bridging mitochondria, sarcolemma and antiarrhythmic therapy

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondrial SK channel enhancement reduces cardiac arrhythmia trigger. Spontaneous sarcoplasmic reticulum (SR) Ca2+ release via hyperactive RyR2s underlies an increased arrhythmia trigger, promoting early and delayed afterdepolarizations during stress. Hyperactive RyR2s causes rise in cytosolic [Ca2+] during diastole. Clearance
Dmitry Terentyev, Alexey V. Glukhov, Vladimir Bogdanov, Aleksei S. Averin, Roland Veress, Bum‐Rak Choi, Shanna Hamilton, Andriy E. Belevych   +7 more
wiley   +1 more source

Calmodulinopathies: The Need for a Registry. [PDF]

Circ Genom Precis Med
Schwartz PJ, Crotti L.
europepmc   +2 more sources