Results 61 to 70 of about 122,133 (302)

Piezo1 Participated in Decreased L-Type Calcium Current Induced by High Hydrostatic Pressure via. CaM/Src/Pitx2 Activation in Atrial Myocytes

Frontiers in Cardiovascular Medicine, 2022
Hypertension is a major cardiovascular risk factor for atrial fibrillation (AF) worldwide. However, the role of mechanical stress caused by hypertension on downregulating the L-type calcium current (ICa,L), which is vital for AF occurrence, remains ...
Yuan Fang, Yuan Fang, Qian Li, Qian Li, Xin Li, Xin Li, Guan-Hao Luo, Guan-Hao Luo, Su-Juan Kuang, Su-Juan Kuang, Xue-Shan Luo, Xue-Shan Luo, Qiao-Qiao Li, Qiao-Qiao Li, Hui Yang, Hui Yang, Yang Liu, Yang Liu, Chun-Yu Deng, Chun-Yu Deng, Yu-Mei Xue, Yu-Mei Xue, Shu-Lin Wu, Shu-Lin Wu, Fang Rao, Fang Rao   +25 more
doaj   +1 more source

An Anterior Cingulate Cortex‐Anterior Insular Cortex Glutamatergic Circuit Gates Stress‐Induced Visceral Hypersensitivity and Anxiety via Ionotropic Glutamate Receptors Trafficking

Advanced Science, EarlyView.
This study identifies an anterior cingulate cortex (ACC) to anterior insular cortex (AIC) glutamatergic (Glu) circuit that gates stress induced visceral hypersensitivity and anxiety. Circuit activation induces both phenotypes, whereas inhibition relieves them.
Junwen Wang, Guangbing Duan, Huihui Sun, Zhiyu Dong, Qiwei Wang, Xiaowei Li, Ying Chen, Shuchang Xu, Ying Huang   +8 more
wiley   +1 more source

Calmodulin-binding protein CBP60g functions as a negative regulator in Arabidopsis anthocyanin accumulation. [PDF]

, 2017
Anthocyanins, a kind of flavonoid, normally accumulate in the flowers and fruits and make them colorful. Anthocyanin accumulation is regulated via the different temporal and spatial expression of anthocyanin regulatory and biosynthetic genes.
Guojing Li (155533), Dongli Wan, Ruili Li, Guojing Li, Dongli Wan (720990), Ruili Li (470065), Bo Zou, Xiaomin Han, Xiaomin Han (304447), Ruigang Wang (155540), Ruigang Wang, Bo Zou (1332738)   +11 more
core   +1 more source

Loss of S100A1 expression leads to Ca2+ release potentiation in mutant mice with disrupted CaM and S100A1 binding to CaMBD2 of RyR1

Physiological Reports, 2018
Calmodulin (CaM) and S100A1 fine‐tune skeletal muscle Ca2+ release via opposite modulation of the ryanodine receptor type 1 (RyR1). Binding to and modulation of RyR1 by CaM and S100A1 occurs predominantly at the region ranging from amino acid residue ...
Erick O. Hernández‐Ochoa, Zephan Melville, Camilo Vanegas, Kristen M. Varney, Paul T. Wilder, Werner Melzer, David J. Weber, Martin F. Schneider   +7 more
doaj   +1 more source

An IQSEC2 Mutation Associated With Intellectual Disability and Autism Results in Decreased Surface AMPA Receptors

Frontiers in Molecular Neuroscience, 2019
We have recently described an A350V mutation in IQSEC2 associated with intellectual disability, autism and epilepsy. We sought to understand the molecular pathophysiology of this mutation with the goal of developing targets for drug intervention.
Eli J. Rogers, Reem Jada, Kinneret Schragenheim-Rozales, Megha Sah, Marisol Cortes, Matthew Florence, Nina S. Levy, Rachel Moss, Randall S. Walikonis, Raz Palty, Reut Shalgi, Daniela Lichtman, Alexandra Kavushansky, Nashaat Z. Gerges, Itamar Kahn, George K. E. Umanah, Andrew P. Levy   +16 more
doaj   +1 more source

Calcineurin‐Dependent Stress Adaptation Enables Caspofungin Heteroresistance Leading to Stable Resistance in Candida Glabrata

Advanced Science, EarlyView.
Caspofungin heteroresistance is prevalent in clinical Candida glabrata isolates and depends on calcineurin‐mediated stress adaptation. This transient phenotype serves as a reservoir for resistance evolution, enabling the emergence of stable resistant descendants under prolonged drug pressure.
Yanyu Su, Yi Li, Meng Xiao, Dan Guo, David S. Perlin, Erika Shor, Yingchun Xu, Yingxing Li   +7 more
wiley   +1 more source

Kinetics and mapping of Ca-driven calmodulin conformations on skeletal and cardiac muscle ryanodine receptors

Nature Communications
Calmodulin transduces [Ca2+] information regulating the rhythmic Ca2+ cycling between the sarcoplasmic reticulum and cytoplasm during contraction and relaxation in cardiac and skeletal muscle.
Robyn T. Rebbeck, Bengt Svensson, Jingyan Zhang, Montserrat Samsó, David D. Thomas, Donald M. Bers, Razvan L. Cornea   +6 more
doaj   +1 more source

CALB2 is a Mechanoresistance Gene in Metastatic Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer cell lines of differing origins were cultured over many passages while being subjected to semi‐lethal levels of fluid shear stress, representing the harsh mechanical environment these cells are subjected to in the circulation during the process of distant metastasis.
Abigail R. Fabiano, Allen C. Luo, Paul Taufalele, Jenna A. Dombroski, Ehsan Aalaei, Schyler J. Rowland, Melissa S. Cantú, Alexandria T. Carter, Samantha V. Knoblauch, Cynthia A. Reinhart‐King, Michael R. King   +10 more
wiley   +1 more source

Purification of Calmodulin-Stimulated Phosphodiesterase by Affinity-Chromatography on Calmodulin Fragment-1-77 Linked to Sepharose [PDF]

, 1988
Because of the presence of many calmodulin-binding proteins in brain, affinity chromatography based on binding to calmodulin lacks specificity. Additional conventional purification steps are needed, prolonging the length of the purification procedure ...
Draetta, G., Klee, C. B., Giulio Draetta, Claude B. Klee   +3 more
core   +1 more source

Calmodulin binds to the N-terminal domain of the cardiac sodium channel Nav1.5. [PDF]

, 2020
The cardiac voltage-gated sodium channel Nav1.5 conducts the rapid inward sodium current crucial for cardiomyocyte excitability. Loss-of-function mutations in its gene SCN5A are linked to cardiac arrhythmias such as Brugada Syndrome (BrS).
Vermij, Sarah H., Sottas, Valentin, Pitt, Geoffrey S, Zaklyazminskaya, Elena V, Shestak, Anna, Rougier, Jean-Sébastien, Wang, Zizun, Hudmon, Andy, Ross-Kaschitza, Daniela, Abriel, Hugues   +9 more
core   +1 more source